Role of the aromatic hydrocarbon receptor in the suppression of cytochrome P-450 2C11 by polycyclic aromatic hydrocarbons

Toxicology Letters

Volumn 90, Issue 2-3, 1997, Pages 163-175

  Safa, Behnam ^a   Lee, Chunja ^a   Riddick, David S ^a  

^a UNIVERSITY OF TORONTO   (Canada)

Author keywords

AH receptor; Cytochrome P 450; Polycyclic aromatic hydrocarbons; Rat hepatocyte

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; 3 METHYLCHOLANTHRENE; 7,12 DIMETHYLBENZ[A]ANTHRACENE; ANTHRACENE; AROMATIC HYDROCARBON RECEPTOR; BENZ[A]ANTHRACENE; CYTOCHROME P450; DIBENZ[A,C]ANTHRACENE; DIBENZ[A,H]ANTHRACENE; POLYCYCLIC AROMATIC HYDROCARBON;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INDUCTION; LIVER CELL CULTURE; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN MODIFICATION; RAT; STRUCTURE ACTIVITY RELATION;

ANIMALS; ARYL HYDROCARBON HYDROXYLASES; CYTOCHROME P-450 ENZYME SYSTEM; ENZYME INDUCTION; LIVER; MALE; POLYCYCLIC HYDROCARBONS, AROMATIC; RATS; RECEPTORS, ARYL HYDROCARBON; STEROID 16-ALPHA-HYDROXYLASE; STEROID HYDROXYLASES; STRUCTURE-ACTIVITY RELATIONSHIP;

ANIMALIA;

EID: 0031557141     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-4274(96)03843-X     Document Type: Article

References (40)

1. [1] Okey, A.B., Riddick, D.S. and Harper, P.A. (1994) Molecular biology of the aromatic hydrocarbon (dioxin) receptor. Trends Pharmacol. Sci. 15, 226-232.
2. [2] Pollenz, R.S., Sattler, C.A. and Poland, A. (1994) The aryl hydrocarbon receptor and aryl hydrocarbon receptor nuclear translocator protein show distinct subcellular localizations in Hepa-1c1c7 cells by immunofluorescence microscopy. Mol. Pharmacol. 45, 428-438.
3. [3] Okey, A.B., Bondy, G.P., Mason, M.E., Nebert, D.W., Forster-Gibson, C.J., Muncan, J. and Dufresne, M.J. (1980) Temperature-dependent cytosol-to-nucleus translocation of the Ah receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin in continuous cell culture lines. J. Biol. Chem. 255, 11415-11422.
4. [4] Perdew, G.H. (1992) Chemical cross-linking of the cytosolic and nuclear forms of the Ah receptor in hepatoma cell line 1c1c7. Biochem. Biophys. Res. Commun. 182, 55-62.
5. [5] Hoffman, E.G., Reyes, H., Chu, F.F., Sander, F., Conley, L.H., Brooks, B.A. and Hankinson, O. (1991) Cloning of a factor required for activity of the Ah (dioxin) receptor. Science 252, 954-958.
6. [6] Denison, M.S., Fisher, J.M. and Whitlock, J.P., Jr. (1988) The DNA recognition site for the dioxin-Ah receptor complex. Nucleotide sequence and functional analysis. J. Biol. Chem. 263, 17221-17224.
7. 1-450 gene transcription by 2,3,7,8-tetrachlorodibenzo-p-dioxin in wild type and variant mouse hepatoma cells. J. Biol. Chem. 259, 5400-5402.
8. [8] Safe, S.H. (1986) Comparative toxicology and mechanism of polychlorinated dibenzo-p-dioxins and dibenzofurans. Annu. Rev. Pharmacol. Toxicol. 26, 371-399.
9. [9] Bigelow, S.W. and Nebert, D.W. (1982) The Ah regulatory gene product. Survey of nineteen polycyclic aromatic compounds' and fifteen benzo[a]pyrene metabolites' capacity to bind to the cytosolic receptor. Toxicol. Lett. 10, 109-118.
10. [10] Piskorska-Pliszczynska, J., Keys, B., Safe, S. and Newman, M.S. (1986) The cytosolic receptor binding affinities and AHH induction potencies of 29 polynuclear aromatic hydrocarbons. Toxicol. Lett. 34, 67-74.
11. [11] Riddick, D.S., Huang, Y., Harper, P.A. and Okey, A.B. (1994) 2,3,7,8-Tetrachlorodibenzo-p-dioxin versus 3-methylcholanthrene. Comparative studies of Ah receptor binding, transformation, and induction of CYP1A1. J. Biol. Chem. 269, 12118-12128.
12. [12] Lin, F.H., Clark, G., Birnbaum, L.S., Lucier, G.W. and Goldstein, J.A. (1991) Influence of the Ah locus on the effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on the hepatic epidermal growth factor receptor. Mol. Pharmacol. 39, 307-313.
13. [13] Lin, F.H., Stohs, S.J., Birnbaum, L.S., Clark, G., Lucier, G.W. and Goldstein, J.A. (1991) The effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on the hepatic estrogen and glucocorticoid receptors in congenic strains of Ah responsive and Ah nonresponsive C57BL/6J mice. Toxicol. Appl. Pharmacol. 108, 129-139.
14. 2 expression in a human keratinocyte cell line involves both transcriptional and post-transcriptional control. J. Biol. Chem. 267, 24591-24595.
15. [15] Waxman, D.J. and Chang, T.K.H. (1995) Hormonal regulation of liver cytochrome P450 enzymes. In: P.R. Ortiz de Montellano (Ed.), Cytochrome P450: Structure, Mechanism, and Biochemistry, 2nd edition, Plenum Press, New York, pp. 391-417.
16. [16] Guengerich, F.P., Dannan, G.A., Wright, S.T., Martin, M.V. and Kaminsky, K.S. (1982) Purification and characterization of liver microsomal cytochromes P-450: electrophoretic, spectral, catalytic, and immunochemical properties and inducibility of eight isozymes isolated from rats treated with phenobarbital or β-naphthoflavone. Biochemistry 21, 6019-6030.
17. [17] Shimada, M., Murayama, N., Yamauchi, K., Yamazoe, Y. and Kato, R. (1989) Suppression in the expression of a male-specific cytochrome P450, P450-male: difference in the effect of chemical inducers on P450-male mRNA and protein in rat livers. Arch. Biochem. Biophys. 270, 578-587.
18. [18] Yeowell, H.N., Waxman, D.J., Wadhera, A. and Goldstein, J.A. (1987) Suppression of the constitutive, male-specific rat hepatic cytochrome P-450 2c and its mRNA by 3,4,5,3′,4′,5′-hexachlorobiphenyl and 3-methylcholanthrene. Mol. Pharmacol. 32, 340-347.
19. [19] Jones, E.J. and Riddick, D.S. (1996) Regulation of constitutive rat hepatic cytochromes P450 by 3-methylcholanthrene. Xenobiotica 26, 995-1012.
20. [20] Dannan, G.A., Guengerich, P.P., Kaminsky, L.S. and Aust, S.D. (1983) Regulation of cytochrome P-450. Immunochemical quantitation of eight isozymes in liver microsomes of rats treated with polybrominated biphenyl congeners. J. Biol. Chem. 258, 1282-1288.
21. [21] Yoshihara, S., Nagata, K., Wada, L, Yoshimura, H., Kuroki, H. and Masuda, Y. (1982) A unique change of steroid metabolism in rat liver microsomes induced with highly toxic polychlorinated biphenyl (PCB) and polychlorinated dibenzofuran (PCDF). J. Pharm. Dyn. 5, 994-1004.
22. [22] Guzelian, P.S., Li, D., Schuetz, E.G., Thomas, P., Levin, W., Mode, A. and Gustafsson, J.-A. (1988) Sex change in cytochrome P-450 phenotype by growth hormone treatment of adult rat hepatocytes maintained in a culture system on matrigel. Proc. Natl. Acad. Sci. USA 85, 9783-9787.
23. [23] Liddle, C., Mode, A., Legraverend, C. and Gustafsson, J.-A. (1992) Constitutive expression and hormonal regulation of male sexually differentiated cytochromes-P450 in primary cultured rat hepatocytes. Arch. Biochem. Biophys. 298, 159-166.
24. [24] Bradford, M.M. (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72, 248-254.
25. [25] Laemmli, U.K. (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227, 680-685.
26. [26] Towbin, H., Staehelin, T. and Gordon, J. (1979) Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc. Natl. Acad. Sci. USA 76, 4350-4354.
27. [27] Denison, M.S., Vella, L.M. and Okey, A.B. (1986) Structure and function of the Ah receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin. Species difference in molecular properties of the receptors from mouse and rat hepatic cytosols. J. Biol. Chem. 261, 3987-3995.
28. [28] Tsui, H.W. and Okey, A.B. (1981) Rapid vertical tube rotor gradient assay for binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin to the Ah receptor. Can. J. Physiol. Pharmacol. 59, 927-931.
29. [29] Denison, M.S. and Yao, E.F. (1991) Characterization of the interaction of transformed rat hepatic cytosolic Ah receptor with a dioxin responsive transcriptional enhancer. Arch. Biochem. Biophys. 284, 158-166.
30. [30] Yeowell, H.N., Waxman, D.J., LeBlanc, G.A., Linko, P. and Goldstein, J.A. (1989) Suppression of male-specific cytochrome P450 2c and its mRNA by 3,4,5,3′,4′,5′-hexachlorobiphenyl in rat liver is not causally related to changes in serum testosterone. Arch. Biochem. Biophys. 271, 508-514.
31. [31] Cuthill, S., Wilhelmsson, A. and Poellinger, L. (1991) Role of the ligand in intracellular receptor function: receptor affinity determines activation in vitro of the latent dioxin receptor to a DNA-binding form. Mol. Cell. Biol. 11, 401-411.
32. [32] Santostefano, M., Piskorska-Pliszczynska, J., Morrison, V. and Safe, S. (1992) Effects of ligand structure on the in vitro transformation of the rat cytosolic aryl hydrocarbon receptor. Arch. Biochem. Biophys. 297, 73-79.
33. [33] Legraverend, C., Mode, A., Westin, S., Strom, A., Eguchi, H., Zaphiropoulos, P.G. and Gustafsson, J.-A. (1992) Transcriptional regulation of rat P-450 2C gene subfamily members by the sexually dimorphic pattern of growth hormone secretion. Mol. Endocrinol. 6, 259-266.
34. [34] Paine, A.J. (1990) The maintenance of cytochrome P-450 in rat hepatocyte culture: some applications of liver cell cultures to the study of drug metabolism, toxicity and the induction of the P-450 system. Chem.-Biol. Interact. 74, 1-31.
35. [35] Chen, J.Q., Strom, A., Gustafsson, J.-A. and Morgan, E.T. (1995) Suppression of the constitutive expression of cytochrome P-450 2C11 by cytokines and interferons in primary cultures of rat hepatocytes: comparison with induction of acute-phase genes and demonstration that CYP2C11 promoter sequences are involved in the suppressive response to interleukins 1 and 6. Mol. Pharmacol. 47, 940-947.
36. [36] Kocarek, T.A., Schuetz, E.G. and Guzelian, P.S. (1993) Expression of multiple forms of cytochrome P450 messenger RNAs in primary cultures of rat hepatocytes maintained on matrigel. Mol. Pharmacol. 43, 328-334.
37. [37] Okey, A.B. and Vella, L.M. (1982) Binding of 3-methylcholanthrene and 2,3,7,8-tetrachlorodibenzo-p-dioxin to a common Ah receptor site in mouse and rat hepatic cytosols. Eur. 3. Biochem. 127, 39-47.
38. [38] Houser, W., Hines, R. and Bresnick, E. (1985) Implication of the '4S' polycyclic aromatic binding protein in the transregulation of rat cytochrome P-450c expression. Biochemistry 24, 7839-7845.
39. [39] LeBlanc, G.A. and Waxman, D.J. (1988) Feminization of rat hepatic P-450 expression by cisplatin. Evidence for perturbations in the hormonal regulation of steroid-metabolizing enzymes. J. Biol. Chem. 263, 15732-15739.
40. [40] Strom, A., Eguchi, H., Mode, A., Legraverend, C., Toilet, P., Stromstedt, P.E. and Gustafsson, J.-A. (1994) Characterization of the proximal promoter and two silencer elements in the CYP2C11 gene expressed in rat liver. DNA Cell Biol. 13, 805-819.