Experimental evidence for toxic damage induced by a dimeric anthracenone: Diast T-514 (peroxisomicine A2)

Toxicology Letters

Volumn 90, Issue 2-3, 1997, Pages 155-162

  Javier Martínez, Francisco ^b   Ramírez Durón, Rosalba ^a   Waksman De Torres, Noemí ^a   Piñeyro López, Alfredo ^a  

^a Depto de Farmacologia y Toxicologia   (Mexico)

^b UNIVERSIDAD AUTÓNOMA DE NUEVO LEÓN   (Mexico)

Author keywords

Diast T 514; Dimeric anthracenones; Karwinskia; Karwinskia parvifolia; Liver toxicity; Peroxisomicine

Indexed keywords

ANTHRACENE DERIVATIVE; PLANT TOXIN;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DEATH; DOSE RESPONSE; DRUG ISOLATION; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HISTOPATHOLOGY; INTRAPERITONEAL DRUG ADMINISTRATION; KIDNEY; LIVER; LUNG; MOUSE; NONHUMAN; ORAL DRUG ADMINISTRATION; PHYTOCHEMISTRY; PLANT; PRIORITY JOURNAL; THIN LAYER CHROMATOGRAPHY; ULTRAVIOLET SPECTROPHOTOMETRY;

ADMINISTRATION, ORAL; ANIMALS; ANTHRACENES; ANTINEOPLASTIC AGENTS, PHYTOGENIC; DIMERIZATION; FEMALE; INJECTIONS, INTRAPERITONEAL; LIVER DISEASES; MICE; MICE, INBRED STRAINS; ORGAN SPECIFICITY; POLYMERS; PULMONARY EDEMA;

ANIMALIA; KARWINSKIA; KARWINSKIA PARVIFOLIA; RHAMNACEAE;

EID: 0031557133     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-4274(96)03842-8     Document Type: Article

References (17)

1. [1] Johnston, M.C. (1966) Year Book of the American Philosophical Society, pp. 351-357.
2. [2] Standley, P.C. (1923) Rhamnaceae in Trees and Shrubs of Mexico. US Natl. Herb. 23, 715.
3. [3] Waksman, N., Martínez, L. and Fernández, R. (1989) Chemical and Toxicological screening in genus Karwinskia (México). Rev. Latinoam. Quim. 20, 27-29.
4. [4] Bermúdez, M.V., González-Spencer, D., Guerrero, M., Waksman, N., and Piñeyro, A. (1986) Experimental intoxication with fruit and purified toxins of Buckthorn (Karwinskia humboldtiana). Toxicon 24, 1091-1097.
5. [5] Bermúdez, M.V., Martinez, F., Salazar, M., Waksman, N., Piñeyro, A. (1992) Experimental acute intoxication with ripe fruit of Karwinskia humboldtiana (Tullidora) in rat, guinea-pig, hamster and dog. Toxicon 30, 1493.
6. [6] Dreyer, A.I., Bachman, C., Anderson, W., Smith, R. and Daves, D. (1975) Toxins causing non-inflammatory paralytic neuropathy. Isolation and structure elucidation. J. Am. Chem. Soc. 97, 4986-4990.
7. [7] Guerrero, M., Piñeyro, A. and Waksman, N. (1987) Extraction and quantification of toxins from Karwinskia humboldtiana (tullidora). Toxicon 25, 565-568.
8. [8] Sepúlveda, S.J., Van der Klei, I.J., Keizer, I., Piñeyro, L. A., Harder, W. and Veenhuis, M. (1992) Studies on the effect of toxin T-514 on the integrity of peroxisomes in methylotrophic yeasts. FEMS Microbiol. Lett. 91, 207-212.
9. [9] Moreno, S.M., Vargas, Z.R., Esquivel, E.D., Waksman, N., Piñeyro, L.A. (1995) Effect of peroxisomicine and related anthracenones on catalase activity. Planta Med. 61 (4), 337-340.
10. [10] Piñeyro-López, A., Martínez de Villarreal, L. and González Alanís, R. (1994) In vitro selective toxicity of toxin T 514 from K. humboldtiana (Buckthorn) plant on various human tumor cell lines. Toxicology 92, 217-227.
11. [11] Garza, L., Hiseh, G., Acosta, D., Torres, O. and Piñeyro, A. (1992) Toxicity assessment of toxins T514 and T544 of buckthorn (K. humboldtiana) in primary skin and liver cell cultures. Toxicology 73, 191-201.
12. [12] Waksman, N. and Ramírez, R. (1992) Isolation of a new dimeric anthracenone from Karwinskia parvifolia. Rev. Latinoam. Quím. 23, 25-27.
13. [13] Salazar, M.L., Piñeyro, A. and Waksman, N. (1996) A reverse phase HPLC method for quantification of peroxisomicine and other anthracenonic compounds. J. Liq. Chrom. Rel. Technol. 19, 1391-1403.
14. [14] Committee on Care and Use of Laboratory Animals. Guide for the Care and Use of Laboratory Animals. (Rev. 1985) NIH Publication, pp. 86-23.
15. [15] Kluver, H. and Barrera, E. (1960) Method for myelin and nerve cells, In: L.G., Luna (Ed.), Manual of Histologie Staining Methods. 3rd Ed, McGraw-Hill, New York.
16. [16] Piñeyro-Lopez, A. (1990) Toxicidad selectiva 'in vitro' de 1a T-514 de Karwinskia Humboldtiana. Doctoral Dissertation. Universidad Autónoma de Nuevo León, Monterrey, N.L., México.
17. [17] Finney, D.J. (1962) Probits Analysis. A Statistical Treatment of the Sigmoid Response Curve. Cambridge University Press, Cambridge.