CDP-choline: Alkylacetylglycerol cholinephosphotransferase catalyzes the final step in the de novo synthesis of platelet-activating factor

Biochimica et Biophysica Acta - Lipids and Lipid Metabolism

Volumn 1348, Issue 1-2, 1997, Pages 111-116

  Snyder, Fred ^a  

^a OAK RIDGE ASSOCIATED UNIVERSITIES   (United States)

Author keywords

Alkylacetylglycerol; CDP choline; Cholinephosphotransferase; De novo synthesis; Platelet activating factor

Indexed keywords

CHOLINEPHOSPHOTRANSFERASE; PHOSPHATIDYLCHOLINE; THROMBOCYTE ACTIVATING FACTOR;

BIOSYNTHESIS; ENDOPLASMIC RETICULUM; ENZYME ACTIVITY; ENZYME SPECIFICITY; HUMAN; ISOTOPE LABELING; LIVER; NONHUMAN; PRIORITY JOURNAL; REACTION ANALYSIS; REVIEW; SPLEEN;

ANIMALS; CATALYSIS; DIACYLGLYCEROL CHOLINEPHOSPHOTRANSFERASE; PLATELET ACTIVATING FACTOR; SUBCELLULAR FRACTIONS; SUBSTRATE SPECIFICITY;

MAMMALIA;

EID: 0031552933     PISSN: 00052760     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0005-2760(97)00109-4     Document Type: Review

References (31)

1. Demopoulos C.A., Pinkard R.N., Hanahan D.J. Platelet-activating factor. Evidence for 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine as the active component (a new class of lipid chemical mediators. J. Biol Chem. 254:1979;9355-9358.
2. Blank M.L., Snyder F., Byers L.W., Brooks B., Muirhead E.E. Antihypertensive activity of an alkyl ether analog of phosphatidylcholine. Biochem. Biophys. Res. Commun. 90:1979;1194-1200.
3. Benveniste J., Tence M., Varenne P., Bidault J., Boullet C., Polonsky J. Semi-synthese et structure proposee du facteur activant les plaquettes (P.A.F.).; PAF-acether, un alkyl ether analogue de la lysophosphatidylcholine. C.R. Acad. Sci. Paris. 289(D):1979;1037-1040.
4. Renooij W., Snyder F. Biosynthesis of 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet-activating factor and a hypotensive lipid) by a cholinephosphotransferase in various rat tissues. Biochim. Biophys. Acta. 663:1981;545-546.
5. Woodard D., Lee T.-C., Snyder F. The final step in the de novo biosynthesis of platelet-activating factor. Properties of a unique CDP-choline: 1-alkyl-2-acetyl-sn-glycerol cholinephosphotransferase in microsomes from the renal inner medulla of rats. J. Biol. Chem. 262:1987;2520-2527.
6. Lee T.-c., Malone B., Snyder F. A new de novo pathway for the formation of 1-alkyl-2-lyso-sn-glycero-3-P, a precursor of platelet-activating factor. Biochemical characterization of 1-alkyl-2-lyso-sn-glycero-3-P:acetyl-CoA acetyltransferase. J. Biol. Chem. 261:1986;5373-5377.
7. Lee T.-c., Malone B., Snyder F. Formation of 1-alkyl-2-acetyl-sn-glycerols via a de novo biosynthetic pathway for platelet-activating factor. Characterization of 1-alkyl-2-acetyl-sn-glycero-3-phosphate phosphohydrolase in rat spleens. J. Biol. Chem. 263:1988;1755-1760.
8. Coleman R., Bell R.M. Phospholipid biosynthesis in isolated fat cells. J. Biol. Chem. 252:1977;3050-3056.
9. Francescangeli E., Goracci G. The de novo biosynthesis of platelet-activating factor in rat brain. Biochem. Biophys. Res. Commun. 161:1989;107-112.
10. Goracci G., Francescangeli E. Properties of PAF-synthesizing phosphocholinetransferase and evidence for lyso-PAF acetyltransferase activity in rat brain. Lipids. 26:1991;986-991.
11. Francescangeli E., Domanska-Janik K., Goracci G. Relative contribution of the de novo and remodeling pathways to the synthesis of platelet-activating factor in brain areas and during ischemia. J. Lipid Mediat. Cell Signal. 14:1996;89-98.
12. Baker R.R., Chang H.-Y. The potential for platelet-activating factor synthesis in rat brain: properties of cholinephosphotransferase and 1-alkyl-sn-glycero-3-phosphate acetyltransferase in microsomal fractions of immature rabbit cerebral cortex. Biochim. Biophys. Acta. 1170:1993;157-164.
13. D.E. Vance, Glycerolipid biosynthesis in eukaryotes, in: D.E. Vance, J. Vance (Eds.), Biochemistry of Lipids, Lipoproteins and Membranes. Elsevier, Amsterdam, 1996, pp. 153-181.
14. Snyder F. Platelet-activating factor: the biosynthetic and catabolic enzymes. Biochem. J. 305:1995;689-705.
15. Snyder F. Platelet-activating factor and its analogs: metabolic pathways and related intracellular processes. Biochim. Biophys. Acta. 1254:1995;231-249.
16. Lee T.-c., Snyder F. 1-Alkyl-2-acetyl-sn-glycerol cholinephosphotransferase. Methods Enzymol. 209:1992;279-283.
17. Fernandez-Gallardo S., Gijon M.A., Garcia M.C., Cano E., Sanchez-Crespo M. Biosynthesis of platelet activating factor in glandular mucosa. Evidence for the involvement of the `de novo' pathway and modulation by fatty acids. Biochem. J. 254:1988;707-714.
18. Alonzo F., Garcia Gil M., Sanchez-Crespo M., Mato J.M. Activation of 1-alkyl-2-lyso-glycero-3-phosphocholine. Acetyl-CoA transferase during phagocytosis in human polymorphonuclear leukocytes. J. Biol. Chem. 257:1982;3376-3378.
19. T.-c. Lee, B. Malone, F. Snyder, Comparative studies on the biosynthesis of platelet-activating factor through a de novo pathway in rat kidneys and rabbit platelets, in: P. Braquet, K.H. Hsieh, E. Pirotzky, J.M. Mencia-Huerta (Eds.), Platelet-activating Factor in Immune Responses and Renal Diseases, Excerpta Medica Asia Ltd., Hong Kong, 1989, pp. 1-4.
20. Bussolino F., Gremo F., Tetta C., Pescarmona G.P., Camussi G. Production of platelet-activating factor by chick retina. J. Biol. Chem. 261:1986;16502-16508.
21. Bussolino F., Pescarmona G.P., Camussi G. Acetylcholine and dopamine promote the production of platelet activating factor in immature cells of chick embryonic retina. J. Neurochem. 51:1988;1755-1759.
22. Kudolo G.B., Harper M.J. Lyso-PAF:acetyl-CoA acetyltransferase and CDP-choline cholinephosphotransferase in the rabbit endometrium. J. Lipid Mediat. Cell Signal. 11:1995;145-158.
23. Hoffman D.R., Bateman M.K., Johnston J.M. Synthesis of platelet-activating factor by cholinephosphotransferase in developing fetal rabbit lung. Lipids. 23:1988;96-100.
24. Wells X.E., O'Neill C. Detection and preliminary characterization of two enzymes involved in the biosynthesis of platelet-activating factor in mouse oocytes, zygotes, and preimplantation embryos: 1-O-alkyl-2-acetyl-sn-glycerol cholinephosphotransferase and acetyl-coenzyme A:1-O-alkyl-2-lyso-sn-glycero-3-phosphocholine acetyltransferase. J. Reprod. Fertil. 101:1994;385-391.
25. Vance D.E., Choy P.C., Farren S.B., Lim P.H., Schneider W.J. Asymmetry of phospholipid biosynthesis. Nature. 270:1977;268-269.
26. Coleman R., Bell R.M. Evidence that biosynthesis of phosphatidylethanolamine, phosphatidylcholine, and triacylglycerol occurs on the cytoplasmic side of microsomal vesicles. J. Cell Biol. 76:1978;245-253.
27. Blank M.L., Lee Y.J., Cress E.A., Snyder F. Stimulation of the de novo pathway for the biosynthesis of platelet activating factor (PAF) via cytidylyltransferase activation in cells with minimal endogenous PAF production. J. Biol. Chem. 263:1988;5656-5661.
28. Vallari D.S., Record M., Snyder F. Conversion of alkylacetylglycerol to platelet-activating factor in HL-60 cells and subcellular localization of the mediator. Arch. Biochem. Biophys. 276:1990;538-545.
29. Lee T.-c., Malone B., Blank M.L., Fitzgerald V., Snyder F. Regulation of the synthesis of platelet-activating factor and its inactive storage precursor (1-alkyl-2-acyl-sn-glycero-3-phosphocholine) from 1-alkyl-2-acetyl-sn-glycerol by rabbit platelets. J. Biol. Chem. 265:1990;9181-9187.
30. Heller R., Bussolino F., Ghigo D., Garbarino G., Pescarmona G., Till U., Bosia A. Stimulation of platelet-activating factor synthesis in human endothelial cells by activation of the de novo pathway. J. Biol. Chem. 266:1991;21358-21361.
31. Lee T.-c., Malone B., Woodard D., Snyder F. Renal necrosis and the involvement of a single enzyme of the de novo pathway for the biosynthesis of platelet-activating factor in rat kidney inner medulla. Biochem. Biophys. Res. Commun. 163:1989;1002-1005.