γ-Carbamate butenolide analogues as potent ET(A) selective endothelin receptor antagonists and prodrugs

Bioorganic and Medicinal Chemistry Letters

Volumn 7, Issue 3, 1997, Pages 297-302

  Patt, William C ^a   Reisdorph, Billy R ^a   Repine, Joseph T ^a   Doherty, Annette M ^a   Haleen, Stephen J ^a   Walker, Donnelle M ^a   Welch, Kathleen M ^a   Flynn, Michael A ^a   Hallak, Hussein ^a   Reyner, Eric L ^a   Stewart, Barbra H ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 (4 METHOXYPHENYL) 2 (3,4 METHYLENEDIOXYPHENYL) 4 OXO 3 (3,4,5 TRIMETHOXYBENZYL) 2 BUTENOIC ACID; BUTENOLIDE; ENDOTHELIN A RECEPTOR; ENDOTHELIN RECEPTOR ANTAGONIST; PD 163140; PRODRUG; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARACHIDONIC ACID METABOLISM; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DIASTEREOISOMER; DRUG RECEPTOR BINDING; DRUG STABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; FEMORAL ARTERY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; HYDROLYSIS; IN VITRO STUDY; INTESTINE; KIDNEY ARTERY; NONHUMAN; PH; QUANTITATIVE STRUCTURE ACTIVITY RELATION; RABBIT; RAT; REACTION ANALYSIS; REGIONAL PERFUSION; ULTRAVIOLET SPECTROPHOTOMETRY; VASOCONSTRICTION;

EID: 0031552105     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(97)00002-4     Document Type: Article

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