Selective cytotoxicity of certain 9-substituted ellipticines for leukemia cells in a variety of leukemia cell cultures

Bioorganic and Medicinal Chemistry Letters

Volumn 7, Issue 3, 1997, Pages 369-372

  Devraj, Rajesh ^a   Cushman, Mark ^a  

^a PURDUE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

9 HYDROXYMETHYLELLIPTICINE; ANTINEOPLASTIC AGENT; ELLIPTICINE; ELLIPTICINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL; CELL CULTURE; CONTROLLED STUDY; CYTOTOXICITY; DRUG SPECIFICITY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IN VITRO STUDY; LEUKEMIA CELL; LEUKEMIA CELL LINE;

EID: 0031552101     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(97)00021-8     Document Type: Article

References (9)

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3. 3. Paull, K. D.; Shoemaker, R. H.; Hodes, L.; Monks, A.; Scudiero, D. A.; Rubinstein, L.; Plowman, J.; Boyd, M. R. J. Natl. Cancer Inst. 1989, 81, 1088-1092.
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5. 5. a) Jurayj, J.; Haugwitz, R. D.; Varma, R. K.; Paull, K. D.; Barrett, J. F.; Cushman, M. J. Med. Chem. 1994, 37, 2190-2197;
6. b) Anderson, W. K.; Gopalsamy, A.; Reddy, P. S. J. Med. Chem. 1994, 37, 1955-1963;
7. c) Acton, E. M.; Narayanan, V. L.; Risbood, P. A.; Shoemaker, R. H.; Vistica, D. T., and Boyd; M. R. J. Med. Chem. 1994, 37, 2185-2189.
8. 6. Plug, J. P. M.; Koomen, G.-J.; Pandit, U. K. Synthesis 1992, 1221-1222.
9. 6, 300 MHz) δ 11.38 (s, 1 H), 9.70 (s, 1 H), 8.43 (d, 1 H, J = 6 Hz), 8.38 (s, 1 H), 7.92 (d, 1 H, J = 6 Hz), 7.53 (s, 2 H), 4.55 (br s, 2 H), 3.97 (s, 2 H), 3.56 (m, 4 H), 3.28 (s, 3 H), 2.79 (s, 3 H), 2.73 (br t, 4 H).