Homogeneous DNA hydrolysis by cerium(IV)/lanthanide(III)/dextran ternary complexes

Chemistry Letters

Volumn , Issue 6, 1997, Pages 507-508

  Sumaoka, Jun ^a   Kajimura, Ayako ^a   Ohno, Masayuki ^b   Komiyama, Makoto ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b SAITAMA INSTITUTE OF TECHNOLOGY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0031533746     PISSN: 03667022     EISSN: None     Source Type: Journal    
DOI: 10.1246/cl.1997.507     Document Type: Article

References (17)

1. P. B. Dervan, Science (Washington D. C.), 232, 464 (1986); M. Komiyama, J. Biochem., 118, 665 (1995) and references therein.
2. P. B. Dervan, Science (Washington D. C.), 232, 464 (1986); M. Komiyama, J. Biochem., 118, 665 (1995) and references therein.
3. For metal-mediated hydrolysis of various phosphoesters, see K. Kimura, "Progress in Inorganic Chemistry," ed by K. D. Karlin, John-Wiley & Sons, New York (1994), Vol 41, p 443.
4. The intrinsic half-life of the phosphodiester linkage in DNA at pH 7 and 25°C is estimated to be 200 million years: J. Chin, V. Banaszczyk, V. Jubian, and X. Zou, J. Am. Chem. Soc., 111, 186 (1989).
5. Y. Matsumoto and M. Komiyama, Nucleic Acids. Symp. Ser., 27, 33 (1992); T. Shiiba, K. Yonezawa, N. Takeda, Y. Matsumoto, M. Yashiro, and M. Komiyama, J. Mol. Catal., 84, L21 (1993).
6. Y. Matsumoto and M. Komiyama, Nucleic Acids. Symp. Ser., 27, 33 (1992); T. Shiiba, K. Yonezawa, N. Takeda, Y. Matsumoto, M. Yashiro, and M. Komiyama, J. Mol. Catal., 84, L21 (1993).
7. M. Komiyama, T. Shiiba, T. Kodama, N. Takeda, J. Sumaoka, and M. Yashiro, J. Biochem., 115, 809 (1994); B. K. Takasaki and J. Chin, J. Am. Chem. Soc., 116, 1121 (1994); M. Komiyama, N. Takeda, Y. Takahashi, H. Uchida, T. Shiiba, T. Kodama, and M. Yashiro, J. Chem. Soc., Perkin Trans. 2, 1995, 269.
8. M. Komiyama, T. Shiiba, T. Kodama, N. Takeda, J. Sumaoka, and M. Yashiro, J. Biochem., 115, 809 (1994); B. K. Takasaki and J. Chin, J. Am. Chem. Soc., 116, 1121 (1994); M. Komiyama, N. Takeda, Y. Takahashi, H. Uchida, T. Shiiba, T. Kodama, and M. Yashiro, J. Chem. Soc., Perkin Trans. 2, 1995, 269.
9. M. Komiyama, T. Shiiba, T. Kodama, N. Takeda, J. Sumaoka, and M. Yashiro, J. Biochem., 115, 809 (1994); B. K. Takasaki and J. Chin, J. Am. Chem. Soc., 116, 1121 (1994); M. Komiyama, N. Takeda, Y. Takahashi, H. Uchida, T. Shiiba, T. Kodama, and M. Yashiro, J. Chem. Soc., Perkin Trans. 2, 1995, 269.
10. N. Takeda, T. Imai, M. Irisawa, J. Sumaoka, M. Yashiro, and M. Komiyama, Chem. Lett., 1996, 599.
11. Homogeneous solutions of bimetallic La(III)/Fe(III) system hydrolyze linear DNA: M. Irisawa and M. Komiyama, J. Biochem., 117, 465 (1995). However, the activity is not sufficient to hydrolyze DNA under the physiological conditions.
12. Plasmid DNA, which takes a supercoiled structure, was hydrolyzed by metal complexes: L. M. T. Schnaith, R. S. Hanson, and L. Que, Jr., Proc. Natl. Acad. Sci. U. S. A., 91. 569 (1994); J. Rammo, R. Hettich, A. Roigk, and H.-J. Schneider, J. Chem. Soc., Chem. Commun., 1996, 105.: S. Hashimoto and Y. Nakamura, J. Chem. Soc., Perkin Trans. 1, 1996, 2623 and references cited therein.
13. Plasmid DNA, which takes a supercoiled structure, was hydrolyzed by metal complexes: L. M. T. Schnaith, R. S. Hanson, and L. Que, Jr., Proc. Natl. Acad. Sci. U. S. A., 91. 569 (1994); J. Rammo, R. Hettich, A. Roigk, and H.-J. Schneider, J. Chem. Soc., Chem. Commun., 1996, 105.: S. Hashimoto and Y. Nakamura, J. Chem. Soc., Perkin Trans. 1, 1996, 2623 and references cited therein.
14. Plasmid DNA, which takes a supercoiled structure, was hydrolyzed by metal complexes: L. M. T. Schnaith, R. S. Hanson, and L. Que, Jr., Proc. Natl. Acad. Sci. U. S. A., 91. 569 (1994); J. Rammo, R. Hettich, A. Roigk, and H.-J. Schneider, J. Chem. Soc., Chem. Commun., 1996, 105.: S. Hashimoto and Y. Nakamura, J. Chem. Soc., Perkin Trans. 1, 1996, 2623 and references cited therein.
15. In this case, however, the homogeneous solution gradually became turbid as the reaction proceeded.
16. 10 No homogeneous solutions were obtained when either amylose or poly(vinylalcohol) was used in place of dextran. The metal complexes with poly(acrylic acid) were inactive for DNA hydrolysis.
17. The gradual decrease of the rate at the [Pr]/[Ce] ratio > 0.5 is probably associated with the competitive binding of the substrate by free Pr(III) ion in the solutions.