Use of a titanium thienyl anion and a simple procedure for introducing a thiol group into thiophene in the development of a manufacturing route to the 5-lipoxygenase inhibitor ZD4407

Organic Process Research and Development

Volumn 1, Issue 1, 1997, Pages 61-67

  Hutton, Jonathan ^a   Jones, Andrew D ^a   Lee, Stanley A ^a   Martin, David M G ^a   Meyrick, Brian R ^a   Patel, Lan ^a   Peardon, Rachel F ^a   Powell, Lyn ^a  

^a ASTRAZENECA   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0031530989     PISSN: 10836160     EISSN: None     Source Type: Journal    
DOI: 10.1021/op960029g     Document Type: Article

References (5)

1. Bird, T. G. C; Crawley, G. C: Large, M. S.; Pie, P. European Patent Application No. 0623614 A1.
2. For general entrainment procedures, see: Fieser, L. F.; Fieser, M. Reagents for Organic Synthesis; Wiley: New York, 1969; Vol. 1, p 417. Pearson, D. E.; Cowan, D.; Beckler, J. D. J. Org. Chem. 1959, 24, 504. For procedures specific to 3-bromothiophenes: see Gronowitz, S.; Pettersson, K. J. Heterocycl. Chem. 1976, 13. 1099.
3. For general entrainment procedures, see: Fieser, L. F.; Fieser, M. Reagents for Organic Synthesis; Wiley: New York, 1969; Vol. 1, p 417. Pearson, D. E.; Cowan, D.; Beckler, J. D. J. Org. Chem. 1959, 24, 504. For procedures specific to 3-bromothiophenes: see Gronowitz, S.; Pettersson, K. J. Heterocycl. Chem. 1976, 13. 1099.
4. For general entrainment procedures, see: Fieser, L. F.; Fieser, M. Reagents for Organic Synthesis; Wiley: New York, 1969; Vol. 1, p 417. Pearson, D. E.; Cowan, D.; Beckler, J. D. J. Org. Chem. 1959, 24, 504. For procedures specific to 3-bromothiophenes: see Gronowitz, S.; Pettersson, K. J. Heterocycl. Chem. 1976, 13. 1099.
5. Holt, R. A.; Rigby, S. R.; Waterson, D. Pending British Patent Application No. 23924.0/95.