Simultaneous determination of menaquinone-4 and its metabolite in human osteoblasts by high-performance liquid chromatography/atmospheric pressure chemical ionization tandem mass spectrometry

Analytical Sciences

Volumn 13, Issue 1, 1997, Pages 67-73

  Sano, Yoshihisa ^a   Kikuchi, Kiyomi ^a   Tadano, Kyoichi ^a   Hoshi, Kazuko ^b   Koshihara, Yasuko ^b  

^a EISAI CO LTD   (Japan)

^b TOKYO METROPOLITAN INSTITUTE OF GERONTOLOGY   (Japan)

Author keywords

Mass spectrometry; Menaquinone 4; Metabolism; Osteoblast; Vitamin K; carboxylase

Indexed keywords

ATMOSPHERIC IONIZATION; ATMOSPHERIC PRESSURE; BONE; CARBOXYLATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IONIZATION OF LIQUIDS; METABOLISM; METABOLITES; OSTEOBLASTS; PROTEINS;

ATMOSPHERIC PRESSURE CHEMICAL IONIZATION MASS SPECTROMETRY; CHEMICAL IONIZATION; MENAQUINONE-4; SELECTED REACTION MONITORING; SELECTIVITY AND SENSITIVITY; SIMULTANEOUS DETERMINATIONS; TANDEM MASS SPECTROMETRY; VITAMIN K;

MASS SPECTROMETRY;

EID: 0031521837     PISSN: 09106340     EISSN: None     Source Type: Journal    
DOI: 10.2116/analsci.13.67     Document Type: Article

References (23)

1. J. W. Suttie, Hepatology, 7, 367 (1987).
2. C. Vermeer, Biochem. J., 266, 625 (1990).
3. M. J. Shearer, Blood Rev., 6, 92 (1992).
4. Y. Koshihara, K. Hoshi and M. Shiraki, J. Clin. Exp. Med., 161, 439 (1992).
5. Y. Koshihara, K. Hoshi, H. Ishibashi and M. Shiraki, Calcif. Tissue Int., in press.
6. Y. Koshihara and K. Hoshi, J. Bone Miner. Res., in press.
7. Y. Akiyama, K. Hara, I. Ohkawa and T. Tajima, Jpn. J. Pharmacol., 62, 145 (1993).
8. H. Orimo, T. Fujita, T. Onomura, T. Inoue, K. Kushida and M. Shiraki, Clin. Eval., 20, 45 (1992).
9. K. Kinoshita, K. Katayama, H. Horie, T. Matsuura, T. Takamatsu, J. Tsutsumi, C. Yamato, T. Fujita, K. Miyao, S. Baba and T. Konishi, Oyo Yakuri-Pharmacometrics, 5, 505 (1971).
10. J. Hirate, I. Horikoshi, J. Watanabe, K. Tadano, C. Yamato and T. Fujita, Oyo Yakuri-Pharmacometrics, 29, 775 (1985).
11. K. Tadano, T. Yuzuriha and Y. Miyake, J. Nutr. Sci. Vitaminol., 35, 393 (1989).
12. K. Tadano, T. Yuzuriha, T. Ikeuchi, T. Sato and T. Fujita, J. Pharmacobio-Dyn., 12, 646 (1989).
13. Y. Sano, K. Tadano, K. Kaneko, K. Kikuchi and T. Yuzuriha, Jpn. Pharmacol. Ther., 23, 2659 (1995).
14. Y. Sano, K. Tadano, K. Kikuchi, K. Kaneko and T. Yuzuriha, J. Nutr. Sci. Vitaminol., 39, 555 (1993).
15. Y. Sano, K. Tadano, K. Kaneko, K. Kikuchi and T. Yuzuriha, Xenobio. Metabol. Dispos., in press.
16. Y. Sano, K. Tadano, K. Kikuchi, K. Kaneko, T. Yuzuriha, T. Kimura and Y. Murayama, Xenobio. Metabol. Dispos., in press.
17. Y. Sano, K. Tadano, K. Kaneko, K. Kikuchi and T. Yuzuriha, J. Nutr. Sci. Vitaminol., 41, 499 (1995).
18. Y. Koshihara, K. Hoshi and M. Shiraki, Biochem. Pharmacol., 46, 1355 (1993).
19. B. Kaye, M. W. H. Clark, N. J. Cussans, P. V. Macrae and D. A. Stopher, Biol. Mass Spectrom., 21, 585 (1992).
20. T. V. Olah, J. D. Gilbert and A. Barrish, J. Pharm. Biomed. Anal., 11, 157 (1993).
21. D. R. Doerge, S. Bajic, L. R. Blankenship, S. W. Preece and M. I. Churchwell, J. Mass Spectrom., 30, 911 (1995).
22. N. G. Knebel, S. R. Sharp and M. J. Madigan, J. Mass Spectrom., 30, 1149 (1995).
23. T. Yasuda, M. Tanaka and K. Iba, J. Mass Spectrom., 31, 879 (1996).