SELEX and the evolution of genomes

Current Opinion in Genetics and Development

Volumn 7, Issue 6, 1997, Pages 848-851

  Gold, Larry ^a,b   Singer, Britta ^b   He, Yi Yuan ^b   Brody, Ed ^c  

^a GILEAD SCIENCES   (United States)

^b UNIVERSITY OF COLORADO   (United States)

^c CNRS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

RNA;

ANIMAL CELL; ANTIBODY COMBINING SITE; ANTIGEN BINDING; DNA SEQUENCE; GENE EXPRESSION REGULATION; GENETIC LINKAGE; GENOME; HUMAN; HUMAN CELL; INTRON; MOLECULAR EVOLUTION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SHORT SURVEY;

EID: 0031474865     PISSN: 0959437X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-437X(97)80050-0     Document Type: Article

References (27)

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6. Gold L, Brown D, He Y-y, Shtatland T, Singer BS, Wu Y. From oligonucleotide shapes to genomic SELEX: novel biological regulatory loops. of outstanding interest Proc Natl Acad Sci USA. 94:1997;59-64 An initial and complementary presentation of the ideas in this paper. The argument is made that, as SELEX frequently yields high affinity ligands to any target, the in vivo SELEX may have been a common event during evolution.
7. Tuerk C, Gold L. Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase. Science. 249:1990;505-510.
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19. Singer BS, Shtatland T, Brown D, Gold L. Libraries of genomic SELEX. Nucleic Acids Res. 25:1997;781-786.
20. Evangelista C, Lockshon D, Fields S. The yeast two-hybrid system: prospects for protein linkage maps. of outstanding interest Trends Cell Biol. 6:1996;196-199 The formal argument that protein linkage maps can and should be made. This report contains a discussion about false positives and false negatives. We are left with the notion that most positives and negatives in this system are real.
21. Yang M, Wu Z, Fields S. Protein - peptide interactions analyzed with the yeast two-hybrid system. Nucleic Acids Res. 23:1995;1152-1156.
22. Chien C-T, Bartel PL, Stenglanz R, Fields S. The two-hybrid system: a method to identify and clone genes for proteins that interact with a protein of interest. Proc Natl Acad Sci USA. 88:1991;9578-9582.
23. Fields S, Song O-K. A novel genetic system to detect protein-protein interactions. Nature. 340:1989;245-246.
24. Bartel PL, Fields S. Analyzing protein - protein interactions using two-hybrid system. Methods Enzymol. 254:1995;241-263.
25. Bartel PL, Roecklein JA, Sengupta D, Fields S. A protein linkage map of Escherichia coli Bacteriophage T7. of outstanding interest Nat Genet. 12:1996;72-77 A model study for protein linkage maps in a simple organism. The conclusions are that even in such a simple organism there are unexpected protein - protein interactions.
26. Brent R. Looms to weave genomic nets. Nat Genetics. 16:1997;216-217.
27. Fromont-Racine M, Rain J-C, Legrain P. Toward a functional analysis of the yeast genome through exhaustive two-hybrid screens. of outstanding interest Nat Genet. 16:1997;277-282 A second lovely example of protein linkage maps and their contribution to the study of regulatory networks. References [20, 25, 27] (and many others) ask and answer many of the questions one would ask about protein/nucleic acid linkage maps, especially with regard to the issues surrounding false positives. We sense that the scientific community is moving toward a simple idea regarding hits from the yeast two-hybrid system: until proven otherwise, a hit is biologically relevant. Over time, we expect hits from genomic SELEX to become accepted as meaningful until proven otherwise.