Curvilinearity in the dose-response curve for cancer in Japanese atomic bomb survivors

Environmental Health Perspectives

Volumn 105, Issue SUPPL. 6, 1997, Pages 1505-1509

  Little, Mark P ^a   Muirhead, Colin R ^a  

^a PUBLIC HEALTH ENGLAND   (United Kingdom)

Author keywords

Cancer; Dose response curve; Japanese atomic bomb survivors; Leukemia; Threshold

Indexed keywords

ANALYTICAL ERROR; ATOMIC BOMB SURVIVOR; CANCER INCIDENCE; CANCER STATISTICS; CONFERENCE PAPER; CONTROLLED STUDY; DATA ANALYSIS; DOSE RESPONSE; DOSIMETRY; FEMALE; HUMAN; JAPAN; LEUKEMIA; MALE; MATHEMATICAL MODEL; PHYSICAL MODEL; PRIORITY JOURNAL; RADIATION DOSE; RISK FACTOR; SKIN CANCER; STATISTICAL ANALYSIS;

EID: 0031473963     PISSN: 00916765     EISSN: None     Source Type: Journal    
DOI: 10.1289/ehp.97105s61505     Document Type: Conference Paper

References (33)

1. International Commission on Radiological Protection (ICRP). 1990 Recommendations of the International Commission on Radiological Protection. Ann ICRP 21, Pts 1-3 (1991).
2. Shimizu Y, Kato H, Schull WJ. Studies of the mortality of A-bomb survivors. 9. Mortality, 1950-1985: Part 2. Cancer mortality based on the recently revised doses (DS86). Radiat Res 121:120-141 (1990).
3. Pierce DA, Vaeth M. The shape of the cancer mortality dose-response curve for the A-bomb survivors. Radiat Res 126:36-42 (1991).
4. United Nations Scientific Committee on the Effects of Atomic Radiation. Sources and Effects of Ionizing Radiation. New York:United Nations, 1993.
5. Otake M, Schull WJ, Yoshimaru H. A Review of Radiation-Related Brain Damage in the Prenatally Exposed Atomic Bomb Survivors. RERF Commentary and Review CR 4-89. Hiroshima:Radiation Effects Research Foundation, 1990.
6. Otake M, Schull WJ. Radiation-related small head sizes among prenatally exposed A-bomb survivors. Int J Radiat Biol 63:255-270 (1993).
7. Thompson DE, Mabuchi K, Ron E, Soda M, Tokunaga M, Ochikubo S, Sugimoto S, Ikeda T, Terasaki M, Izumi S et al. Cancer incidence in atomic bomb survivors. Part II: solid tumors, 1958-1987. Radiat Res 137:517-567 (1994).
8. Preston DL, Kusumi S, Tomonaga M, Izumi S, Ron E, Kuramoto A, Kamada N, Dohy H, Matsuo T, Nonaka H et al. Cancer incidence in atomic bomb survivors. Part III: leukemia, lymphoma and multiple myeloma, 1950-1987. Radiat Res 137:S68-S97 (1994).
9. Jablon S. Atomic Bomb Radiation Dose Estimation at ABCC. ABCC Tech Rep TR 23-71. Hiroshima:Atomic Bomb Casualty Commission, 1971.
10. Gilbert ES. Some effects of random dose measurement errors on analyses of atomic bomb survivor data. Radiat Res 98:591-605 (1984).
11. Pierce DA, Stram DO, Vaeth M. Allowing for random errors in radiation dose estimates for the atomic bomb survivor data. Radiat Res 123:275-284 (1990).
12. Little MP, Muirhead CR. Evidence For curvilinearity in the cancer incidence dose-response in the Japanese atomic bomb survivors. Int J Radiat Biol 70:83-94 (1996).
13. McCullagh P, Nelder JA. Generalized Linear Models. 2nd ed. London:Chapman and Hall, 1989.
14. Little MP. Risks of radiation-induced cancer at high doses and dose rates. J Radiol Prot 13:3-25 (1993).
15. Muirhead CR, Cox R, Stather JW, MacGibbon BH, Edwards AA, Haylock RGE. Estimates of late radiation risks to the UK population. Docs NRPB 4(4):15-157 (1993).
16. U.S. National Academy of Sciences Committee on the Biological Effects of Ionizing Radiations. Health Risks of Radon and other Internally-deposited Alpha-emitters (BEIR IV). Washington:National Academy Press, 1988.
17. Lubin JH, Boice JD, Edling C, Hornung RW, Howe GR, Kunz E, Kusiak RA, Morrison HI, Radford EP, Samet JM et al. Lung cancer in radon-exposed miners and estimation of risk from indoor exposure. J Natl Cancer Inst 87:817-827 (1995).
18. Rowland RE, Stehney AF, Lucas HF. Dose-response relationships for female radium dial workers. Radiat Res 76:368-383 (1978).
19. Straume T, Egbert SD, Woolson WA, Finkel RC, Kubik PW, Gove HE, Sharma P, Hoshi M. Neutron discrepancies in the DS86 Hiroshima dosimetry system. Health Phys 63:421-426 (1992).
20. Preston DL, Pierce D, Vaeth M. Neutrons and radiation risk: a commentary. In: RERF Update, Vol 4, No 4. Hiroshima: Radiation Effects Research Foundation, 1992;5.
21. Aoyama T, Radford EP, Yonehara H, Kato H, Sakanoue M. Radon Concentrations in Residential Housing in Hiroshima and Nagasaki. RERF Tech Rep TR 8-91. Hiroshima:Radiation Effects Research Foundation, 1993.
22. Kato K, Antoku S, Sawada S, Russell WJ. Organ doses received by atomic bomb survivors during radiological examinations at the Radiation Effects Research Foundation. Br J Radiol 64:720-727 (1991).
23. Schervish MJ. Theory of Statistics. New York:Springer-Verlag, 1995.
24. Papworth DG, Hulse EV. Dose-response models for the radiation-induction of skin tumours in mice. Int J Radiat Biol 44:423-431 (1983).
25. Mole RH, Papworth DG, Corp MJ. The dose-response for X-ray induction of myeloid leukaemia in male CBA/H mice. Br J Cancer 47:285-291 (1983).
26. Pohl-Rüling J, Fischer P, Haas O, Obe G, Natarajan AT, Van Buul PPW, Buckton KE, Bianchi NO, Larramendy M, Kučerová M et al. Effect of low-dose acute X-irradiation on the frequencies of chromosomal aberrations in human peripheral lymphocytes in vitro. Mutat Res 110:71-82 (1983).
27. Lloyd DC, Edwards AA, Leonard A, Deknudt GL, Verschaeve L, Natarajan AT, Darroudi F, Obe G, Palitti F, Tanzarella C et al. Chromosomal aberrations in human lymphocytes induced in vitro by very low doses of X-rays. Int J Radiat Biol 61:335-343(1992).
28. Cardis E, Gilbert ES, Carpenter L, Howe G, Kato I, Armstrong BK, Beral V, Cowper G, Douglas A, Fix J et al. Effects of low doses and low dose rates of external ionizing radiation: cancer mortality among nuclear industry workers in three countries. Radiat Res 142:117-132 (1995).
29. Kneale GW, Stewart AM. Age variation in the cancer risks from foetal irradiation. Br J Cancer 35:501-510 (1977).
30. Rabbitts TH. Chromosomal translocations in human cancer. Nature 372:143-149 (1994).
31. Goodhead DT. Initial events in the cellular effects of ionizing radiations: clustered damage in DNA. Int J Radiat Biol 65:7-17 (1994).
32. Goodhead DT, Nikjoo H. Track structure analysis of ultrasoft X-rays compared to high- and low-LET radiations. Int J Radiat Biol 55:513-529 (1989).
33. Thacker J. Radiation-induced mutation in mammalian cells at low doses and dose rates. Adv Radiat Biol 16:77-124 (1992).