Effect of the cannabinoid receptor SPECT agent, AM 281, on hippocampal acetylcholine release from rat brain slices

Neuroscience Letters

Volumn 238, Issue 1-2, 1997, Pages 84-86

  Gifford, Andrew N ^a   Tang, Yunjia ^a   John Gatley, S ^a   Volkow, Nora D ^a   Lan, Ruoxi ^b   Makriyannis, Alexandros ^b  

^a BROOKHAVEN NATIONAL LABORATORY   (United States)

^b UNIVERSITY OF CONNECTICUT   (United States)

Author keywords

Acetylcholine; Cannabinoid receptor; Hippocampus; Marijuana; SPECT

Indexed keywords

2,3 DIHYDRO 5 METHYL 3 (MORPHOLINOMETHYL) 6 (1 NAPHTHOYL)PYRROLO[1,2,3 DE][1,4]BENZOXAZINE; ACETYLCHOLINE; CANNABINOID RECEPTOR; RIMONABANT;

ACETYLCHOLINE RELEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BRAIN SLICE; DRUG ABSORPTION; EVOKED RESPONSE; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR BINDING; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY;

ACETYLCHOLINE; ANIMALS; CANNABINOIDS; FRONTAL LOBE; HIPPOCAMPUS; IODINE RADIOISOTOPES; MORPHOLINES; NAPHTHALENES; PIPERIDINES; PYRAZOLES; RATS;

EID: 0031473751     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(97)00851-3     Document Type: Article

References (9)

1. Deadwyler S.A., Hampson R.E., Mu J., Whyte A., Childers S. Cannabinoids modulate voltage sensitive potassium A-current in hippocampal neurons via a cAMP-dependent process. J. Pharmacol. Exp. Ther. 273:1995;734-743.
2. Gatley, S.J., Lan, R., Volkow, N.D., Pappas, N., King, P., Wong, C.T., Gifford, A.N., Pyatt, B. and Makriyannis, A., Imaging the brain marijuana receptor: development of a radioligand that binds to cannabinoid CB1 receptors in vivo, J. Neurochem., (1997) in press.
3. Gessa G.L., Mascia M.S., Casu M.A., Carta G. Inhibition of hippocampal acetylcholine release by cannabinoids: reversal by SR 141716A. Eur. J. Pharmacol. 327:1997;R1-R2.
4. Gifford A.N., Ashby C.R. Electrically evoked acetylcholine release from hippocampal slices is inhibited by the cannabinoid receptor agonist, WIN 55212-2, and is potentiated by the cannabinoid antagonist, SR 141716A. J. Pharmacol. Exp. Ther. 277:1996;1431-1436.
5. Gifford A.N., Samiian L., Gatley S.J., Ashby C.R. Examination of the effect of the cannabinoid receptor agonist, CP-55,940, on neurotransmitter release from brain slices. Eur. J. Pharmacol. 324:1977;187-192.
6. Herkenham M., Lynn A.B., Johnson M.R., Melvin L.S., de Costa B.R., Rice K.C. Characterization and localization of cannabinoid receptors in rat brain: a quantitative in vitro autoradiographic study. J. Neurosci. 11:1991;563-583.
7. Mackie K., Hille N. Cannabinoids inhibit N-type calcium channels in neuroblastoma-glioma cells. Proc. Natl. Acad. Sci. USA. 89:1992;3825-3829.
8. Mailleux P., Vanderhaeghen J.J. Distribution of neuronal cannabinoid receptor in the adult brain: a comparative receptor binding radioautography and in situ hybridization histochemistry. Neuroscience. 48:1992;655-668.
9. Shen M., Piser T.M., Seybold V.S., Thayer S.A. Cannabinoid receptor agonists inhibit glutaminergic synaptic transmission in rat hippocampal cultures. J. Neurosci. 16:1996;4322-4334.