Lack of bioavailability of mebeverine even after pretreatment with pyridostigmine

European Journal of Clinical Pharmacology

Volumn 53, Issue 3-4, 1997, Pages 247-249

  Sommers, De K ^a   Snyman, J R ^a   Van Wyk, M ^a   Eloff, J N ^a  

^a Faculty of Education   (South Africa)

Author keywords

Bioavailability; Mebeverine; Pyridostigmine; Veratric acid

Indexed keywords

DRUG METABOLITE; MEBEVERINE; PLACEBO; PYRIDOSTIGMINE;

ADULT; ARTICLE; BIOAVAILABILITY; CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG HYDROLYSIS; DRUG METABOLISM; FEMALE; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; PHARMACOKINETICS; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SINGLE BLIND PROCEDURE; VOLUNTEER;

BIOLOGICAL AVAILABILITY; CHOLINESTERASE INHIBITORS; CROSS-OVER STUDIES; FEMALE; HUMANS; MALE; PARASYMPATHOLYTICS; PHENETHYLAMINES; PYRIDOSTIGMINE BROMIDE; SINGLE-BLIND METHOD;

EID: 0031473042     PISSN: 00316970     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002280050370     Document Type: Article

References (8)

1. Connell AM (1965) Physiological and clinical assessment of the effect of the musculotropic agent mebeverine on the human colon. BMJ ii: 848-851
2. Daly J, Bergin A, Sun WM, Read NW (1993) Effect of food and anti-cholinergic drugs on the pattern of rectosigmoid contractions. Gut 34: 799-802
3. Dickinson RG, Baker PV, Franklin ME, Hooper WD (1991) Facile hydrolysis of mebeverine in vitro and in vivo: negligible circulating concentrations of the drue after oral administration. J Pharm Sci 80: 952-957
4. Ivey KJ (1975) Are anticholinergics of use in the irritable colon syndrome? Gastroenterology 68: 1300-1307
5. Kristinsson J, Snorradóttir I, Jóhannsson M (1994) The metabolism of mebeverine in man: identification of urinary metabolites by gas chromatography/mass spectrometry. Pharmacol Toxicol 74: 174-180
6. Kruis W, Weinzierl M, Schüssler P, Holl J (1986) Comparison of the therapeutic effect of wheat bran, mebeverine and placebo in patients with the irritable bowel syndrome. Digestion 34: 196-201
7. Tasman-Jones C (1973) A double blind cross-over trial with mebeverine (Duspatalin) in irritable colon syndrome. NZ Med J 77: 232-235
8. Thompson WG (1984) The irritable bowel. Gut 25: 305-320