Screening of anti-MUC1 antibodies for reactivity with native (ascites) and recombinant (baculovirus) MUC1 and for blocking MUC1 specific cytotoxic T-lymphocytes

Tumor Biology

Volumn 19, Issue SUPPL.1, 1997, Pages 147-151

  Ciborowski, Pawel ^a   Konitzki, William M ^a   Blander, Julie Magarian ^a   Finn, Olivera J ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

Monoclonal antibody; MUC1; TD 4 Workshop

Indexed keywords

MONOCLONAL ANTIBODY; MUCIN;

ANTIBODY RESPONSE; ANTIBODY SPECIFICITY; ANTIGEN RECOGNITION; BACULOVIRUS; CONCENTRATION RESPONSE; CONFERENCE PAPER; CYTOTOXIC T LYMPHOCYTE; EPITHELIUM CELL; GENE CLUSTER; GLYCOSYLATION; NONHUMAN; PANCREAS CANCER; PRIORITY JOURNAL; TARGET CELL; VIRUS EXPRESSION;

EID: 0031470124     PISSN: 10104283     EISSN: None     Source Type: Journal    
DOI: 10.1159/000056516     Document Type: Conference Paper

References (6)

1. Barnd DL, Lan M, Metzgar RS, Finn OJ: Specific, MHC unrestricted recognition of tumor-associated mucins by human cytotoxic T cells, Proc Natl Acad Sci USA 1989;86:7159-7163.
2. Fontenot JD, Santhana Mariappan SV, Catasi P, Domenech N, Finn OJ, Gupta G: Structure of a tumor associated antigen containing a tandenily repeated immunodominant epitope. J Biomol Struct Dyn 1995;13:245-260.
3. Magarian-Blander J, Hughey RP, Kinlough C, Poland PA, Finn OJ: Differential expression of MUC1 on transfected cell lines influences its recognition by MUC1 specific T cells. Glycoconj J 1996;13:749-756.
4. Ciborowski P, Finn OJ: Recombinant epithelial cell mucin (MUC1) expressed in baculovirus resembles antigenically tumor associated mucin, target for cancer immunotherapy. Biomed Pept Proteins Nucl Acids 1995;1:193-198.
5. Jerome KR, Bu D, Finn OJ: Expression of tumor associated epitopes on Epstein-Barr virus immortalized B-cells and Burkitt's lymphomas transfected with epithelial mucin complementary DNA. Cancer Res 1992;52:5985-5990.
6. Laemmli UK: Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970;227:680-685.