Aging and the brain: A new frontier

Annals of Neurology

Volumn 42, Issue 6, 1997, Pages 819-828

  Drachman, David A ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGING; ALZHEIMER DISEASE; CAENORHABDITIS ELEGANS; HUMAN; LIFESPAN; MITOCHONDRIAL RESPIRATION; NERVE CELL DEGENERATION; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; REVIEW;

AGING; ANIMALS; BRAIN; CELL AGING; CELL DEATH; HUMANS; LONGEVITY; NERVOUS SYSTEM DISEASES;

EID: 0031470111     PISSN: 03645134     EISSN: None     Source Type: Journal    
DOI: 10.1002/ana.410420602     Document Type: Review

References (113)

1. Strehler B. Introduction: aging and the human brain. In: Terry R, Gershon S, eds. Neurobiology of aging. New York: Raven Press, 1976:1-22
2. Masoro E. Aging: current concepts. In: Masoro E, ed. Handbook of physiology: aging. New York: Oxford University Press, 1995:3-24
3. Finch C. Longevity, senescence and the genome. Chicago: University of Chicago Press, 1990
4. Cassel C, Brody J. Demography, epidemiology and aging. In: Cassel C, Riesenberg D, Sorensen L, Walsh J, eds. Geriatric medicine. 2nd ed. New York: Springer-Verlag, 1990:16-27
5. Olshansky S, Carnes B, Cassel C. In search of Methuselah: estimating the upper limits to human longevity. Science 1990; 250:634-640
6. Akhtar A, Broe D, Crombie A, et al. Disability and dependence in the elderly at home. Age Aging 1973;2:102-110
7. Broe G, Akhtar A, Andrews G, et al. Neurologic disorders in the elderly at home. J Neurol Neurosurg Psychiat 1976;39: 362-366
8. Tomlinson B, Corsellis J. Ageing and the dementias. In: Adams J, Corsellis J, Duchen L, eds. Greenfield's neuropathology. 4th ed. New York: John Wiley & Sons, 1984:951-1025
9. DeKeyser J, Ebinger G, Vauquelin G. Age-related changes in the human nigrostriatal dopaminergic system. Ann Neurol 1990;27:157-161
10. Coleman P, Flood D. Neuron numbers and dendritic extent in normal aging and Alzheimer's disease. Neurobiol Aging 1987;8:521-545
11. West MJ. Regionally specific loss of neurons in the aging human hippocampus. Neurobiol Aging 1993;14:287-293
12. Wickelgren I. Is hippocampal cell death a myth? Science 1996;271:1229-1230
13. Hamos J, DeGennaro L, Drachman D. Synaptic loss in Alzheimer's disease and other dementias. Neurology 1989;39: 58-61
14. Lippa CF, Hamos JE, Pulaski-Salo D, et al. Alzheimer's disease and aging: effects on perforant pathway perikarya and synapses. Neurobiol Aging 1992;13:405-411
15. Katzman R, Terry R, DeTeresa R. Clinical, pathological, and neurochemical changes in dementia: a subgroup with preserved mental status and numerous neocortical plaques. Ann Neurol 1988;23:138-144
16. Miller F, Hicks S, D'Amato C, Landis J. A descriptive study of neuritic plaques and neurofibrillary tangles in an autopsy population. Am J Epidemiol 1984;120:331-341
17. Ulrich J. Alzheimer changes in nondemented patients younger than sixty-five: possible early stages of Alzheimer's disease and senile dementia of the Alzheimer type. Ann Neurol 1985;17: 273-277
18. Drachman D, Long R, Swearer J. Neurological examination of the elderly patient. In: Albert M, Knoefel J, eds. Clinical neurology of aging. 2nd ed. New York: Oxford University Press, 1994:159-180
19. Drachman D. Memory and cognitive function in normal aging. Dev Neuropsychol 1986;2:277-285
20. Smith A. Memory. In: Birren J, Schaie K, eds. Handbook of the psychology of aging. 4th ed. San Diego: Academic Press, 1996:236-250
21. Salthouse T. Speed of behavior and its implications for cognition. In: Birren J, Schaie K, eds. Handbook of the psychology of aging. 2nd ed. New York: Van Nostrand Reinhart, 1985:400-426
22. Salthouse T. The nature of the influence of speed on adult age differences in cognition. Dev Psychol 1994;30:240-259
23. Branconnier RJ, Cole JO, Spera KF, DeVitt DR. Does "benign senescent forgetfulness" exist? Recall and recognition as diagnostic indices of malignant memory loss in senile dementia: a Bayesian analysis. Clin Geriatr Med 1988;4:897-916
24. Larrabee GJ, McEntee WJ. Prevalence of age-associated memory impairment in a randomly selected population from eastern Finland. Age-associated memory impairment: sorting out the controversies. Neurology 1995;45:741-747 (Editorial)
25. Salthouse TA. Processing speed as a mental capacity: influence of processing speed on adult age differences in working memory. Acta Psychol 1994;86:199-225
26. Wechsler D. The Wechsler Adult Intelligence Scale - revised manual. New York: Psychological Corporation, 1981
27. Horn JL. Psychometric studies of aging and intelligence. In: Gershon S, Raskin A, eds. Aging. New York: Raven Press, 1975:19-43
28. Lehman H. Age and achievement. Princeton: Princeton University Press, 1953
29. Gutmann E, Hanzlikova V. Age changes in the neuromuscular system. Bristol: Scientechnica, 1972
30. Larish D, Martin P, Mungiole E. Characteristic patterns of gait in the healthy old. Ann NY Acad Sci 1988;515:18-32
31. Shock N. The science of gerontology. In: Jeffers E, ed. Proceedings of seminars. Durham: Duke University Press, 1962
32. Saunders A, Strittmatter W, Schmechel D, et al. Association of apolipoprotein E allele ε4 with late-onset familial and sporadic Alzheimer's disease. Neurology 1993;43:1467-1472
33. Seshadri S, Drachman D, Lippa C. Apolipoprotein E ε4 allele and the lifetime risk of Alzheimer's disease: what physicians know, and what they should know. Arch Neurol 1995;52: 1074-1080
34. Jennett B, Teasdale G. Management of head injuries. Philadelphia: FA Davis, 1981:321-322
35. Lanzino G, Kassell N, Germanson T, et al. Age and outcome after aneurysmal subarachnoid hemorrhage: why do older patients fare worse? J Neurosurg 1996;85:410-418
36. Recht LD, McCarthy K, O'Donnell BF, et al. Tumor-associated aphasia in left hemisphere primary brain tumors: the importance of age and tumor grade. Neurology 1989;39: 48-50
37. Finch C. New models for new perspectives in the biology of senescence. Neurobiol Aging 1991;12:625-634
38. Finch C, Pike M, Witten M. Slow mortality rate accelerations during aging in some animals approximate that of humans. Science 1990;249:902-905
39. Masoro E. Biology of aging: facts, thoughts, and experimental approaches. Lab Invest 1991;65:500-510
40. Rose M. Evolutionary biology of aging. New York: Oxford University Press, 1991
41. Carey J, Liedo P, Orozco E, Vaupel J. Slowing of mortality rates at older ages in large medfly cohorts. Science 1992;258: 457-461
42. Oeller P, Min-Wong L, Taylor L, et al. Reversible inhibition of tomato fruit senescence by antisense RNA. Science 1991; 254:437-439
43. Larsen P, Albert P, Riddle D. Genes that regulate both development and longevity in Caenorhabditis elegans. Genetics 1995;139:1567-1583
44. Lakowski B, Hekimi S. Determination of life-span in Caenorhabditis elegans by four clock genes. Science 1996;272:1010-1013
45. Lithgow G. Molecular genetics of Caenorhabditis elegans aging. In: Schneider E, Rowe J, eds. Handbook of the biology of aging. 4th ed. San Diego: Academic Press, 1995:55-73
46. McCay C, Crowell M, Maynard L. The effects of retarded growth upon the length of life span and upon the ultimate body size. J Nutr 1935;10:63-79
47. Sprott R, Austad S. Animal models for aging research. In: Schneider E, Rowe J, eds. Handbook of the biology of aging. 4th ed. San Diego: Academic Press, 1996:3-23
48. Weindruch R, Walford R, Fliegel S, Guthrie D. The retardation of aging in mice by dietary restriction: longevity, cancer, immunity and lifetime energy intake. J Nutr 1986;116:641-654
49. VanRemmen H, Ward W, Sabia R, Richardson A. Gene expression and protein degradation. In: Masoro E, ed. Aging. New York: Oxford University Press, 1995:171-234
50. Johnson T, Hartman P. Radiation effects on life span in Caenorhabditis elegans. J Gerontol Biol Sci 1988;43:B137-141
51. Mine M, Okumura Y, Ichimaru M, et al. Apparently beneficial effect of low to intermediate doses of A-bomb radiation on human lifespan. Int J Radiat Biol 1990;58:1035-1043
52. Hayflick L, Moorhead P. The serial cultivation of human diploid cell strains. Exp Cell Res 1961;25:585-621
53. Hayflick L. The limited in vitro lifetime of human diploid cell strains. Exp Cell Res 1965;37:614-636
54. Hayflick L. The cell biology of human aging. Sci Am 1980; 242:58-65
55. Hayflick L. How and why we age. New York: Ballantine Books, 1994
56. Blasco M, Funk W, Villeponteau B, Greider C. Functional characterization and developmental regulation of mouse telomerase RNA. Science 1995;269:1267-1270
57. Smith J, Pereira-Smith O. Replicative senescence: implications for in vivo aging and tumor suppression. Science 1996;273: 63-67
58. Majno G, Joris I. Apoptosis, oncosis, and necrosis: an overview of cell death. Am J Pathol 1995;146:3-15
59. Monti D, Grassilli E, Troiano L, et al. Senescence, immortalization, and apoptosis. In: Fabris N, Harman D, Knook D, et al, eds. Physiopathological processes of aging. New York: New York Academy of Sciences, 1992:70-82
60. Adams J, Mukherjee S, Klaidman L, et al. Apoptosis and oxidative stress in the aging brain. In: Kitani K, Aoba A, Goto S, eds. Pharmacological intervention in aging and age-associated disorders. New York: New York Academy of Sciences, 1996: 135-151
61. Steller H. Mechanisms and genes of cellular suicide. Science 1995;267:1445-1462
62. Rubin L, Gatchalian C, Rimon G, Brooks S. The molecular mechanisms of neuronal apoptosis. Curr Opin Neurobiol 1994;4:696-702
63. Bump N, Hackett M, Hugunin M, et al. Inhibition of ICE family proteases by baculovirus antiapoptotic protein p35. Science 1995;269:1885-1888
64. Davies A. The Bcl-2 family of proteins, and the regulation of neuronal survival. Trends Neurosci 1993;18:355-358
65. Smale G, Nichols NR, Brady DR, et al. Evidence for apoptotic cell death in Alzheimer's disease. Exp Neurol 1995;133: 225-230
66. Szilard L. On the natute of the aging process. Proc Natl Acad Sci USA 1959;45:30-45
67. Orgel L. The maintenance of the accuracy of protein synthesis and its relevance to ageing. Proc Natl Acad Sci USA 1963;49: 517-521
68. Danner D, Holbrook N. Alterations in gene expression with aging. In: Schneider E, Rowe J, eds. Handbook of the biology of aging. 3rd ed. San Diego: Academic Press, 1990:97-115
69. Norwood T, Smith J, Stein G. Aging at the cellular level: the human fibroblastlike cell model. In: Schneider E, Rowe J, eds. Handbook of the Biology of aging. 3rd ed. San Diego: Academic Press, 1990:131-154
70. Gafni A. Structural modifications of proteins during aging. J Am Geriatr Soc 1997;45:871-880
71. Taubes G. Misfolding the way to disease. Science 1996;271: 1493-1495
72. Johnson T, Lithgow G, Murakami S, et al. Genetics of aging and longevity in lower organisms. In: Holbrook N, Martin G, Lockshin R, eds. Cellular aging and cell death. New York: Wiley-Liss, 1996:1-17
73. Levine R, Stadtman E. Protein modifications with aging. In: Schneider E, Rowe J, eds. Handbook of the biology of aging. 4th ed. San Diego: Academic Press, 1996:184-197
74. Richardson A, Holbrook N. Aging and the cellular response to stress: reduction in the heat shock response. In: Holbrook N, Martin G, Lockshin R, eds. Cellular aging and cell death. New York: Wiley-Liss, 1996:67-80
75. Wu B, Gu M, Heydari A, Richardson A. The effect of age on the synthesis of two heat shock proteins in the HSP70 family. J Gerontol Biol Sci 1993;48:B50-B56
76. Beyreuther K, Masters C. Catching the culprit prion. Nature 1994;370:419-420
77. Prusiner S, Hsiao K. Human prion diseases. Ann Neurol 1994;35:385-395
78. Beal M. Aging, energy, and oxidative stress in neurodegenerative diseases. Ann Neurol 1995;38:357-366
79. Harman D. Role of free radicals in aging and disease. In: Fabris N, Harman D, Knook D, et al, eds. Physiopathological processes of aging. New York: New York Academy of Sciences, 1992:126-141
80. Harman D. Aging and disease. In: Kitani K, Aoba A, Goto S, eds. Pharmacological intervention in aging and age-associated disorders. New York: New York Academy of Sciences, 1996: 321-336
81. Richter C. Oxidative damage to mitochondrial DNA and its relationship to ageing. Int J Biochem Cell Biol 1995;27:647-653
82. Yu BP, Yang R. Critical evaluation of the free radical theory of aging. In: Kitani K, Aoba A, Goto S, eds. Pharmacological intervention in aging and age-associated disorders. New York: New York Academy of Sciences, 1996:1-11
83. Nagley P, Mackay I, Baumer A, et al. Mitochondrial DNA mutation associated with aging and degenerative disease. In: Fabris N, Harman D, Knook D, et al, eds. Physiopathological processes of aging. New York: New York Academy of Sciences, 1992:92-102
84. Wei Y-H, Kao S-H, Lee H-C. Simultaneous increase of mirochondrial DNA deletions and lipid peroxidation in human aging. In: Kitani K, Aoba A, Goto S, eds. Pharmacological intervention in aging and age-associated disorders. New York: New York Academy of Sciences, 1996:24-43
85. Julius M, Lang C, Gleiberman L, et al. Glutathione and morbidity in a community-based sample of elderly. J Clin Epidemiol 1994;47:1021-1026
86. Fletcher R, Fletcher S. Glutathione and ageing: ideas and evidence. Lancet 1994;344:1379-1380
87. Mattson MP. Calcium and neuronal injury in Alzheimer's disease: contributions of beta-amyloid precursor protein mismetabolism, free radicals, and metabolic compromise. Ann NY Acad Sci 1994;747:50-76
88. Knight J. Diseases related to oxygen-derived free radicals. Ann Clin Lab Sci 1995;25:111-121
89. Chiueh C, Mohanakumar K, Sternberger L, et al. In vivo generation of hydroxyl radicals and MPTP-induced dopaminergic toxicity in the basal ganglia. Ann NY Acad Sci 1994;738: 25-36
90. Floyd R. Oxidative damage to behavior during aging. Science 1991;254:1597
91. Wolozin B, Luo Y, Wood K. Neuronal loss in aging and disease. In: Holbrook N, Martin G, Lockshin R, eds. Cellular aging and cell death. New York: Wiley-Liss, 1996:283-302
92. Carney JM, Starke-Reed PE, Oliver CN, et al. Reversal of age-related increase in brain protein oxidation, decrease in enzyme activity, and loss in temporal and spatial memory by chronic administration of rhe spin-trapping compound N-tert-butyl-alpha-phenylnitrone. Proc Natl Acad Sci USA 1991;88: 3633-3636
93. Tolkovsky A, Buckmaster E, Edwards S, et al. Signaling for survival: The biochemistry of NGF dependence in primary sympathetic neurons. In: Holbrook N, Martin G, Lockshin R, eds. Cellular aging and cell death. New York: Wiley-Liss, 1996:267-282
94. Birkenhager-Gillesse E, Derksen J, Lagaay A. Dehydroepiandrosterone sulphate (DHEAS) in the oldest old, aged 85 and over. Ann NY Acad Sci 1994;719:543-552
95. Miller R. Aging and the immune response. In: Schneider E, Rowe J, eds. Handbook of the biology of aging. 4th ed. San Diego: Academic Press, 1996:355-392
96. Pearl R, Pearl R. The ancestry of the long-lived. Baltimore: Johns Hopkins University Press, 1934
97. Strittmatter W, Saunders A, Schmechel D, et al. Apolipoprotein E: high-avidity binding to B-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease. Proc Natl Acad Sci USA 1993;90:1977-1981
98. Levy-Lahad E, Wijsman E, Nemens E, et al. A familial Alzheimer's disease locus on chromosome 1. Science 1995;269: 970-977
99. Sherrington R, Rogaev E, Liang Y, et al. Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. Nature 1995;375:754-760
100. Masoro E. Retardation of aging processes by food restriction: an experimental tool. Am J Clin Nutr 1992;55:1250S-1252S
101. Holloszy J. Exercise and food restriction in rats. J Nutr 1992; 122:774-777
102. Manson J, Willett W, Stampfer M, et al. Body weight and mortality among women. N Engl J Med 1995;333:677-685
103. Castro C, Rudy J. Impaired short-term memory resulting from postnatal undernutrition is attenuated by physostigmine. Behav Neural Biol 1993;60:282-285
104. Drachman D. If we live long enough, will we all be demented? Neurology 1994;44:1563-1565
105. Barker A, Jones R, Jennison C, et al. A prevalence study of age-associated memory impairment. Br J Psych 1995;167: 642-648
106. Hanninen T, Hallikainen M, Koivisto K, et al. Cognitive problems in the elderly. Curr Opin Neurol 1995;8:256-261
107. Salthouse TA. Selective influences of age and speed on associative memory. Am J Psychol 1995;108:381-396
108. Dustman R, Ruhling R, Russell E, et al. Aerobic exercise training and improved neuropsychological function of older individuals. Neurobiol Aging 1984;5:35-42
109. Joseph J, Cao G, Cutler R. In vivo or in vitro administration of the nitrone spin-trapping compound n-tert-butyl-alpha-phenylnitrone (PBN) reduces age-related deficits in striatal muscarinic receptor sensitivity. Brain Res 1995;671:73-77
110. Kordower J, Freeman T, Snow B, et al. Neuropathological evidence of graft survival and striatal reinnervation after the transplantation of fetal mesencephalic tissue in a patient with Parkinson's disease. N Engl J Med 1995;332:1118-1124
111. Olanow C, Kordower J, Freeman T. Fetal nigral transplantation as a therapy for Parkinson's disease. Trends Neurosci 1996;19:102-109
112. Reynolds B, Weiss S. Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system. Science 1992;255:1707-1710
113. Herbert J. The age of dehydroepiandrosterone. Lancet 1995; 345:1193-1194