Regulation of P-glycoprotein expression in cyclic AMP-dependent protein kinase mutants

Cell Growth and Differentiation

Volumn 8, Issue 12, 1997, Pages 1243-1247

  Cvijic, Mary Ellen ^a   Chin, Khew Voon ^a,b  

^a ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

^b RUTGERS CANCER INSTITUTE OF NEW JERSEY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; COLCHICINE; COMPLEMENTARY DNA; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; DNA; DOXORUBICIN; FLOXURIDINE; GLUTAMIC ACID; GLYCINE; GLYCOPROTEIN P; PACLITAXEL;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CHO CELL; CONTROLLED STUDY; DRUG SENSITIVITY; ENZYME ACTIVITY; ENZYME SUBUNIT; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; MULTIDRUG RESISTANCE; MUTANT; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

ANIMALS; ANTINEOPLASTIC AGENTS; BLOTTING, WESTERN; CARRIER PROTEINS; CELL CYCLE; CHO CELLS; CRICETINAE; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DRUG RESISTANCE, NEOPLASM; FLOW CYTOMETRY; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; KB CELLS; MUTATION; P-GLYCOPROTEIN; PROTEIN KINASES;

ANIMALIA;

EID: 0031469808     PISSN: 10449523     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. Gottesman, M. M., and Pastan, I. Biochemistry of multidrug resistance mediated by the multidrug transporter. Annu. Rev. Biochem., 62: 385-427, 1993.
2. Endictoo, J., and Ling, V. The biochemistry of P-glycoprotein mediated multidrug resistance. Annu. Rev. Biochem., 58: 137-171, 1989.
3. Chin, K-V., Pastan, I., and Gottesman, M. M. Function and regulation of the human multidrug resistance gene. Adv. Cancer Res., 60:157-180, 1993.
4. Chin, K-V., Ueda, K., Pastan, I., and Gottesman, M. M. RAS and p53 modulate the promoter of the human multidrug resistance (MDR1) gene. Science (Washington DC), 255: 459-462, 1992.
5. Nguyen, K. T., Liu, B., Ueda, K., Pastan, I., Gottesman, M. M., and Chin, K. V. Transactivation of the human multidrug resistance (MDR1) gene promoter by p53 mutants. Oncol. Res., 6: 71-77, 1994.
6. Chin, K. V., and Liu, B. Regulation of the multidrug resistance (MDR1) gene expression. In Vivo, 8: 835-842, 1994.
7. Abraham, I., Hunter, R. J., Sampson, K. E., Smith, S., Gottesman, M. M., and Mayo, J. K. Cyclic AMP-dependent protein kinase regulates sensitivity of cells to multiple drugs. Mol. Cell. Biol., 7: 3098-3106, 1987.
8. Abraham, I., Chin, K-V., Gottesman, M. M., Mayo, J., and Sampson, K. E. Transfection of a mutant regulatory subunit gene of cAMP-dependent protein kinase causes increased drug sensitivity and decreased expression of P-glycoprotein. Exp. Cell Res., 189: 133-141, 1990.
9. Chin, K-V., Chauhan, S. S., Abraham, I., Sampson, K. E., Krolczyk, A. J., Wong, M., Schimmer, B., Pastan, I., and Gottesman, M. M. Reduced expression of the multidrug-resistant gene in cAMP-dependent protein kinase mutant cell lines. J. Cell. Physiol., 152: 87-94, 1992.
10. Kim, S., Park, J., Chung, B., Kang, C., and Hidaka, H. Inhibition of MDR1 gene expression by H-87, a selective inhibitor of cAMP-dependent protein kinase. Cancer Lett., 74: 37-41, 1993.
11. Daniel, V., Litwack, G., and Tomkins, G. M. Induction of cytolysis of cultured lymphoma cells by adenosine 3′:5′-cyclic monophosphate and the isolation of resistant variants. Proc. Natl. Acad. Sci. USA, 70: 76-79, 1973.
12. Insel, P. A., Bourne, H. R., Coffino, P., and Tomkins, G. M. Cyclic AMP-dependent protein kinase. Pivotal role in regulation of enzyme induction and growth. Science (Washington DC), 190; 896-898, 1975.
13. Gottesman, M. M. Genetic approaches to cyclic AMP effects in cultured mammalian cells. Cell, 22: 329-330, 1980.
14. Gottesman, M. M., LeCam, A., Bukowski, M., and Pastan, I. Isolation of multiple classes of mutants of CHO cells resistant to cyclic AMP. Somatic Cell Genet., 6: 45-61, 1980.
15. Singh, T. J., Hochman, J., Verna, R., Chapman, M., Abraham, I., Pastan, I. H., and Gottesman, M. M. Characterization of a cyclic AMP-resistant Chinese hamster ovary cell mutant containing both wild-type and mutant species of type I regulatory subunit of cyclic AMP dependent protein kinase. J. Biol. Chem., 260: 13927-13933, 1985.
16. Gosse, M. E., Padmanabhan, A., Fleischmann, R. D., and Gottesman, M. M. Expression of Chinese hamster cAMP-dependent protein kinase in Escherichia coli results in growth inhibition of bacterial cells: a model for the rapid screening of mutant type I regulatory subunits. Proc. Natl. Acad. Sci. USA, 90: 8159-8163, 1993.
17. Evain, D., Gottesman, M. M., Pastan, I., and Anderson, W. B. A mutation affecting the catalytic subunit of cyclic AMP-dependent protein kinase in CHO cells. J. Biol. Chem., 254: 6931-6937, 1979.
18. Singh, T. J., Roth, C., Gottesman, M. M., and Pastan, I. H. Characterization of cyclic AMP-resistant Chinese hamster ovary cell mutants lacking type I protein kinase. J. Biol. Chem., 256: 926-932, 1981.
19. Howard, P., Day, K. H., Kim, K. E., Richardson, J., Thomas, J., Abraham, I., Fleischmann, R. D., Gottesman, M. M., and Maurer, R. A. Decreased catalytic subunit mRNA levels and altered catalytic subunit mRNA structure in a cAMP-resistant Chinese hamster ovary cell line. J. Biol. Chem., 266: 10189-10195, 1991.
20. Johnson, G, S., Friedman, R. M., and Pastan, I. Restoration of several morphological characteristics of normal fibroblasts in sarcoma cells treated with adenosine-3′:5′-cyclic monophosphate and its derivatives. Proc. Natl. Acad. Sci. USA, 68: 425-429, 1971.
21. Pastan, I., and Gottesman, M. Multiple-drug resistance in human cancer. N. Engl. J. Med., 316: 1388-1393, 1987.
22. Chin, K-V., Pastan, I., and Gottesman, M. M. Function and regulation of the human multidrug resistance gene. Adv. Cancer Res., 60: 157-180, 1993.
23. Gottesman, M. M., and Pastan, I. Biochemistry of multidrug resistance mediated by the multidrug transporter. Annu. Rev. Biochem., 62: 385-427, 1993.
24. North, P. S., Davies, S. L., Ciardiello, F., Damiano, V., Bianco, C., Pepe, S., Bianco, A. R., Harris, A. L., Hickson, I. D., and Tortora, G. Overexpression of the RIα subunit of protein kinase A confers hypersensitivity to topoisomerase II inhibitors and 8-chloro-cyclic adenosine 3′,5′-monophosphate in Chinese hamster ovary cells. Cancer Res., 54: 4123-4128, 1994.
25. Scala, S., Budillon, A., Zhan, Z., Cho-Chung, Y. S., Jefferson, J. Tsokos, M., and Bates, S. Downregulation of mdr-1 expression by 8-Cl-cAMP in multidrug resistant MCF-7 human breast cancer cells. J. Clin. Invest., 96: 1026-1034, 1995.
26. Rohiff, C., Clair, T., and Cho-Chung, Y. S. 8-Cl-cAMP induces truncation and down-regulation of the RIα subunit and up-regulation of the RIIβ subunit of cAMP-dependent protein kinase leading to type II holoenzyme-dependent growth inhibition and differentiation of HL-60 leukemia cells. J. Biol. Chem., 268: 5774-5782, 1993.
27. Liu, B., Cvijic, M. E., Jetzt, A., and Chin, K-V. Cisplatin resistance and regulation of DNA repair in cAMP-dependent protein kinase mutants. Cell Growth Differ., 7: 1105-1112, 1996.
28. Nishio, K., Morikage, T., Kubota, N., Ohmori, T., Takeda, Y., Fujiwara, Y., Miki, K., Abe, K., and Saijo, N. Alteration of type II regulatory subunit of cAMP-dependent protein kinase in human cisplatin-resistant cells as a basis of collateral sensitivity to 8-chloro-cAMP. Jpn. J. Cancer Res., 83: 754-760, 1992.
29. Coghlan, V. M., Perrino, B. A., Howard, M., Langeberg, L. K., Hicks, J. B., Gallatin, W. M., and Scott, J. D. Association of protein kinase A and protein phosphatase 2B with a common anchoring protein. Science (Washington DC), 267: 108-111, 1995.
30. Constaninou, A. I., Squinto, S. P., and Jungmann, R. A. The phosphoform of the regulatory subunit RII of cyclic AMP-dependent protein kinase posses intrinsic topoisomerase activity. Cell, 42: 429-437, 1985.