GM-237354

Drugs of the Future

Volumn 22, Issue 11, 1997, Pages 1221-1225

  Fromtling, Robert A ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMPHOTERICIN B; ANTIFUNGAL AGENT; FLUCONAZOLE; GM 237354; SORDARIN DERIVATIVE; UNCLASSIFIED DRUG;

ANTIFUNGAL ACTIVITY; CANDIDA ALBICANS; CANDIDIASIS; COLONY FORMING UNIT; DOSE RESPONSE; DRUG SAFETY; DRUG SYNTHESIS; FUNGUS; HISTOPLASMOSIS; IN VITRO STUDY; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PNEUMOCYSTIS CARINII; SHORT SURVEY; YEAST;

EID: 0031469744     PISSN: 03778282     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Short Survey

References (14)

1. Bueno, J.M., Chicharro, J., Huss, S.I., Fiandor, J.M., Gomez de las Heras, F. Synthesis of the antifungal GM237354. 37th Intersci Conf Antimicrob Agents Chemother (Sept 28-Oct 1, Toronto) 1997, Abst F54.
2. Dominguez, J.M., Capa, L., Serramia, M.J., Mendoza, A., Viana, J.M., Garcia-Bustos, J.F., Martin, J.J. Translation elongation factor 2 (EF2) is the target for sordarin-derived antifungals. 37th Intersci Conf Antimicrob Agents Chemother (Sept 28-Oct 1, Toronto) 1997, Abst F55.
3. Herreros, E., Martinez, A., Almela, M.J., Martinez, C.M., Lozano, S., Jimenez, E., Gomez de las Heras, F., Gargallo, D. GM 237354: In vitro selectivity and tolerance in rodents. 37th Intersci Conf Antimicrob Agents Chemother (Sept 28-Oct 1, Toronto) 1997, Abst F59.
4. Sanchez-Sousa, A., Alvarez, M.E., Parra, C., Baquero, F. Activity on clinical yeast isolates of a new antifungal agent, GM 237354. 37th Intersci Conf Antimicrob Agents Chemother (Sept 28-Oct 1, Toronto) 1997, Abst F56.
5. Herreros, E., Martinez, C.M., Almela, M.J., Lozano, S., Gomez de las Heras, F., Gargallo, D. In vitro activity of GM 237354 against a broad range of fungi. 37th Intersci Conf Antimicrob Agents Chemother (Sept 28-Oct 1, Toronto) 1997, Abst F57.
6. Stevens, D.A. Screening of sordaricin derivatives against endemic fungal pathogens. 37th Intersci Conf Antimicrob Agents Chemother (Sept 28-Oct 1, Toronto) 1997, Abst F58.
7. Herreros, E., Martinez, A., Jimenez, E. et al. Anti-pneumocystosis activity of GM 237354 in vitro and in vivo. 37th Intersci Cont Antimicrob Agents Chemother (Sept 28-Oct 1, Toronto) 1997, Abst F64.
8. Martinez, A., Jimenez, E., Aviles, P., Aliouat, E.M., San Roman, R. Gomez de las Heras, F., Gargallo, D. Activity of GM 237354 against murine models of systemic and oral candidiasis. 37th Intersci Conf Antimicrob Agents Chemother (Sept 28-Oct 1, Toronto) 1997, Abst F60.
9. Oakley, K.L., Verweij, P.E., Morrissey, G., Morrissey, J., Denning, D.W. In vivo activity of GM237354 in a neutropenic murine model of aspergillosis. 37th Intersci Conf Antimicrob Agents Chemother (Sept 28-Oct 1, Toronto) 1997, Abst F61.
10. Clemons, K.V., Stevens, D.A. Efficacy of sordaricin derivatives GM193663, GM211676 or GM237354 in a murine model of systemic coccidioidomycosis. 37th Intersci Conf Antimicrob Agents Chemother (Sept 28-Oct 1, Toronto) 1997, Abst F62.
11. Najvar, L.K., Bocanegra, R.A., Fothergill, A.W., Luther, M.F., Graybill, J.R. New sordaricin antifungal drugs active in murine histoplasmosis. 37th Intersci Conf Antimicrob Agents Chemother (Sept 28-Oct 1, Toronto) 1997, Abst F63.
12. Hadley, W.K., Ng, V.L. Pneumocystis. In: Manual of Clinical Microbiology, 6th Edition, P.R. Murray, E.J. Barron, M.A. Pfaller, F.C. Tenover and R.H. Yolken (Eds.), ASM Press, Washington DC, 1995, 738-48.
13. Dei-Cas, E., Aliouat, E.M., Mullet, C., Mazars, E., Gargallo, D. A new antimicrobial molecule (GM 237354) highly active against Pneumocystis carinii: In vivo studies and ultrastructural data. 37th Intersci Conf Antimicrob Agents Chemother (Sept 28-Oct 1, Toronto) 1997, Abst F65.
14. Aviles, P., Pateman, A., San Roman, R., Gargallo, D. Single-dose pharmacokinetic studies in rodents with GM237354, a new systemic antifungal agent. 37th Intersci Conf Antimicrob Agents Chemother (Sept 28-Oct 1, Toronto) 1997, Abst F66.