Hemodynamic effects of acute tetrandrine and terlipressin administration on portal hypertensive rats

Canadian Journal of Physiology and Pharmacology

Volumn 75, Issue 10-11, 1997, Pages 1220-1225

  Huang, Yi Tsau ^a   Tsai, Ju Fen ^a   Lin, Han Chieh ^a,b   Chen, Chieh Fu ^c   Hong, Chuang Ye ^a  

^a NATIONAL YANG MING UNIVERSITY   (Taiwan)

^b TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

^c NATIONAL RESEARCH INSTITUTE OF CHINESE MEDICINE   (Taiwan)

Author keywords

Hemodynamics; Portal hypertension; Terlipressin; Tetrandrine

Indexed keywords

TERLIPRESSIN; TETRANDRINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; HEART INDEX; HEART OUTPUT; HEART RATE; HEMODYNAMICS; INTRAVENOUS DRUG ADMINISTRATION; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; PORTAL HYPERTENSION; PORTAL VEIN BLOOD PRESSURE; PRIORITY JOURNAL; RAT; VASCULAR RESISTANCE;

EID: 0031468553     PISSN: 00084212     EISSN: None     Source Type: Journal    
DOI: 10.1139/y97-145     Document Type: Article

References (36)

1. Albillos, A., Colombato, L.A., and Groszmann, R.J. 1992. Vasodilatation and sodium retention in prehepatic portal hypertension. Gastroenterology, 102: 931-935
2. Blei, A.T., Groszmann, R.J., Gusberg, R., and Conn, H.O. 1980. Comparison of vasopressin and triglycyl-lysine vasopressin on splanchnic and systemic hemodynamics in dogs. Dig. Dis. Sci. 25: 688-694.
3. Chojkier, M., and Groszmann, R.J. 1981. Measurement of portal systemic shunting in the rat by using y-labeled microspheres. Am. J. Physiol. 240: G371-G375.
4. D'Amico, G., Pagliaro, L., and Bosch, J. 1995. The treatment of portal hypertension: a meta-analytic review. Hepatology, 22: 332-354.
5. Escorsell, A., Bandi, J.C., Moitinho, E., Feu, F., Garcia-Pagan, J.C., Bosch, J., and Rodes, J. 1997. Time profile of the haemodynamic effects of terlipressin in portal hypertension. J. Hepatol. 26: 621-627.
6. Freeman, J.G., Barton, J.R., and Record, C.O. 1985. Effect of isosorbide dinitrate, verapamil, and labetolol on portal pressure in cirrhosis. Br. Med. J. 291: 561-562.
7. Genecin, P., and Groszmann, R.J. 1994. The biology of portal hypertension. In The liver: biology and pathobiology. 3rd ed. Edited by I.M. Arias, J.L. Boyer, N. Fausto, W.B. Jakoby, D.A. Schachter, and D.A. Shafritz. Raven Press, New York. pp. 1327-1341.
8. Gimson, A.E.S., Westaby, D., Hayes, P.C., Hegarty, J., Watson, A., and Williams, R. 1986. A randomized trial of vasopressin and vasopressin plus nitroglycerin in the control of acute variceal hemorrhage. Hepatology, 6: 410-413.
9. Groszmann, R.J., Kravetz, D., Bosch, J., Glickman, M., Bruix, J., Bredfeldt, J.E., Conn, H.O., Rodes, J., and Storer, E.H. 1982. Nitroglycerin improves the hemodynamic responses to vasopressin in portal hypertension. Hepatology, 2: 757-762.
10. Hadengue, A., Moreau, R., Cerini, R., Koshy, A., Lee, S.S., and Lebrec, D. 1989. Combination of ketanserin and verapamil or propranolol in patients with alcoholic cirrhosis: search for an additive effect. Hepatology, 9: 83-87.
11. Hori, N., Okanoue, T., Sawa, Y., Itoh, Y., Mori, T., Takami, S., and Kashima, K. 1994. Hemodynamic effects of combined treatment with somatostatin analogue (SMS 201-995) and low-dose isosorbide dinitrate on portal hypertension in conscious cirrhotic rats. J. Gastroenterol. 29: 460-468.
12. Huang, Y.-T., Wang, G.-F., Yang, M.C.M., Chang, S.-P., Lin, H.-C., and Hong, C.-Y. 1996. Vascular hyporesponsiveness in aorta from portal hypertensive rats: possible sites of involvement. J. Pharmacol. Exp.Ther. 278: 535-541.
13. Huang, Y.-T., Cheng, Y.-R., Lin, H.-C., Chen, C.-F., and Hong, C.-Y. 1997. Haemodynamic effects of chronic tetrandrine treatment in portal hypertensive rats. J. Gastroenterol. Hepatol. 12: 585-589.
14. Iwao, T., Toyonaga, A., Ikegami, M., Sugawara, H., Sumino, M., Takagi, K., Oho, K., Sakaki, M., Ohkubo, K., Inoue, R., and Tanikawa, K. 1992. Nicardipine infusion improved hepatic function but failed to reduce hepatic venous pressure gradient in patients with cirrhosis. Am. J. Gastroenterol. 87: 326-331.
15. Kong, C.-W., Lay, C.-S., Tsai, Y.-T., Yeh, C.-L., Lai, K.-H., Lee, S.-D., Lo, K.-J., and Chiang, B.N. 1986. The hemodynamic effect of verapamil on portal hypertension in patients with postnecrotic cirrhosis. Hepatology, 6: 423-426.
16. Koshy, A., Hadengue, A., Lee, S.S., Jiron, M.I., and Lebrec, D. 1987. Possible deleterious hemodynamic effect of nifedipine on portal hypertension in patients with cirrhosis. Clin. Pharmacol. Ther. 42: 295-298.
17. Kroeger, R.J., and Groszmann, R.J. 1985. The effect of the combination of nitroglycerin and propranolol on splanchnic and systemic hemodynamics in a portal hypertensive rat model. Hepatology, 5: 425-430.
18. Lebrec, D. 1994. Pharmacological treatment of portal hypertension: hemodynamic effects and prevention of bleeding. Pharmacol. Ther. 61: 65-107.
19. Lee, F.-Y., Tsai, Y.-T., Lin, H.-C., Lee, S.-D., Hsia, H.-C., Lin, W.-J., Wang, S.-S., Lai, K.-H., and Lo, K.-J. 1992. Hemodynamic effects of a combination of vasopressin and ketanserin in patients with hepatitis B-related cirrhosis. J. Hepatol. 15: 54-58.
20. Lin, H.-C., Tsai, Y.-T., Lee, F.-Y., Chang, T.-T., Wang, S.-S., Lay, C.-S., Lee, S.-D., and Lo, K.-J. 1990. Systemic and portal haemodynamic changes following triglycyllysine vasopressin plus nitroglycerin administration in patients with hepatitis B-related cirrhosis. J. Hepatol. 10: 370-374.
21. ++ antagonist: effects and mechanisms of action in vascular smooth muscle cells. J. Pharmacol. Exp. Ther. 273: 32-39.
22. Liu, T.-B., Lin, H.-C., Huang, Y.-T., Sun, C.-M., and Hong, C.-Y. 1997. Portal hypotensive effects of tetrandrine and verapmil on portal hypertensive rats. J. Pharm. Pharmacol. 49: 85-88.
23. Moreau, R., Cailmail, S., and Lebrec, D. 1994. Effects of vasopressin on haemodynamics in portal hypertensive rats receiving clonidine. Liver, 14: 45-49.
24. Navasa, M., Bosch, J., Reichen, J., Bru, C., Mastai, R., Zysset, T., Silva, G., Chesta, J., and Rodes, J. 1988. Effects of verapamil on hepatic and systemic hemodynamics and liver function in patients with cirrhosis and portal hypertension. Hepatology, 8: 850-854.
25. Oberti, F., Rifflet, H., Maiga, M.Y., Pilette, C., Gallois, Y., Douay, O., Le Jeune, J.-J., Saumet, J.-L., and Cales, P. 1997. Prevention of portal hypertension by propranolol and spironolactone in rats with bile duct ligation. J. Hepatol. 26: 167-173.
26. Qian, J.Q., Thoolen, M.J.M.C., van Meel, J.C.A., Timmermans, P.B.M.W.M., and van Zwieten, P.A. 1983. Hypotensive activity of tetrandrine in rats: investigation into its mode of action. Pharmacology, 26: 187-197.
27. Reichen, J., and Le, M. 1986. Verapamil favorably influences hepatic microvascular exchange and function in rats with cirrhosis of liver. J. Clin. Invest. 78: 448-455.
28. Reichen, J., Hirlinger, A., Ha, H.R., and Sagesser, S. 1986. Chronic verapamil administration lowers portal pressure and improves hepatic function in rats with liver cirrhosis. J. Hepatol. 3: 49-58.
29. Roulot, D., Gaudin, C., Braillon, A., Sekiyama, T., Bacq, Y., and Lebrec, D. 1989. Hemodynamic effects of a combination of clonidine and propranolol in conscious cirrhotic rats. Can. J. Physiol. Pharmacol. 67: 1369-1372.
30. Sogni, P., Soupison, T., Moreau, R., Le Moine, O., Bacq, Y., Hadengue, A., and Lebrec, D. 1994. Hemodynamic effects of acute administration of furosemide in patients with cirrhosis receiving β-adrenergic antagonists. J. Hepatol. 20: 548-552.
31. Tsai, Y.-T., Lay, C.-S., Lai, K.-H., Ng, W.-W., Yeh, Y.-S., Wang, J.-Y., Chiang, T.-T., Lee, S.-D., and Chiang, B.N. 1986. Controlled trial of vasopressin plus nitroglycerin vs. vasopressin alone in the treatment of bleeding esophageal varices. Hepatology, 6: 406-409.
32. Vachiery, F., Moreau, R., Gadano, A., Yang, S., Sogni, P., Hadengue, A., Cailmail, S., Soupison, T., and Lebrec, D. 1996. Hemodynamic and metabolic effects of terlipressin in patients with cirrhosis receiving a nonselective β-blocker. Dig. Dis. Sci. 41: 1722-1726.
33. van de Casteele, M., Roey, G.V., Nevens, F., and Fevery, J. 1996. Effects of varying doses of spironolactone without and with nitrates on portal vein pressure and kidney function in partial portal vein ligated rats. Hepatology, 24: 1492-1496.
34. Vinel, J.P., Caucanas, J.P., Combis, J.M., Cales, P., Voigt, J.J., and Pascal, J.P. 1989. Verapamil has no effect on porto-hepatic pressure gradient, hepatic blood flow and elimination function of the liver in patients with liver cirrhosis. J. Hepatol. 8: 302-307.
35. Walker, S. 1990. Vasoconstrictor therapy in bleeding esophageal varices. Hepato-gastroenterology, 37: 538-543.
36. + channels. Life Sci. 56: 295-306.