Early hemopoietic progenitors in the peripheral blood of patients with severe aplastic anemia (SAA) after treatment with antilymphocyte globulin (ALG), cyclosporin-A and G-CSF

Haematologica

Volumn 82, Issue 2, 1997, Pages 133-137

  Bacigalupo, Andrea ^a   Piaggio, Giovanna ^b   Podestà, Marina ^b   Tong, Jie ^b   Pitto, Anna ^b   Figari, Osvaldo ^b   Benvenuto, Federica ^b   Vassallo, Franca ^b   Tedone, Elisabetta ^b   Grassia, Lidia ^b   Van Lint, Maria Teresa ^b   Gualandi, Francesca ^b   Hoffman, Ronald ^b  

^a UNIVERSITY OF GENOA   (Italy)

^b NONE

Author keywords

Hematopoiesis; Immunosuppressive therapy; Severe aplastic anemia; Stem cells

Indexed keywords

CD34 ANTIGEN; CD8 ANTIGEN; CYCLOSPORIN A; GRANULOCYTE COLONY STIMULATING FACTOR; LYMPHOCYTE ANTIBODY;

ADOLESCENT; ADULT; ANEMIA; APLASTIC ANEMIA; ARTICLE; CHILD; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; LEUKAPHERESIS; MALE; TREATMENT OUTCOME;

ADOLESCENT; ADULT; ANEMIA, APLASTIC; ANTILYMPHOCYTE SERUM; CYCLOSPORINE; FEMALE; GRANULOCYTE COLONY-STIMULATING FACTOR; HEMATOPOIETIC STEM CELLS; HUMANS; IMMUNOSUPPRESSIVE AGENTS; LEUKAPHERESIS; MALE; MIDDLE AGED;

EID: 0031468425     PISSN: 03906078     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. Marsh JCW, Chang J, Testa NG, Hows JM, Dexter TM. The hematopoietic defect in aplastic anemia assessed by long-term marrow culture. Blood 1990; 76:1748-57.
2. Scopes J, Bagnara M, Gordon-Smith EC, Ball SE, Gibson FM. Haemopoietic progenitor cells are reduced in aplastic anemia. Br J Haematol 1994; 86:427-30.
3. Gordon MY. Stem cells and the microenvironment in aplastic anemia. Br J Haematol 1994; 84:190-2.
4. Nissen C. Pathophysiology of aplastic anemia. Bailliére Clin Haematol 1989; 2:237-40.
5. Young NS. The problem of clonality in aplastic anemia: dr. Dameshek's riddle. Restated. Blood 1992; 79:1385-92.
6. Bacigalupo A, Podestà M, Raffo MR, et al. Lack of in vitro colony formation and myelosuppressive activity in patients with severe aplastic anemia after autologous hematologic reconstitution. Exp Hematol 1980; 8:795-801.
7. Orlic D, Bodine DM. What defines a pluripotent hematopoietic stem cell (PHSC): will the real PHSC please stand up! Blood 1994; 85:3991-4.
8. Spangrude GJ, Brooks DM, Tumas DB. Long-term repopulation of irradiated mice with limiting numbers of purified hematopoietic stem cells: in vivo expansion of stem cell phenotype but not function. Blood 1995; 85:1006-16.
9. Bacigalupo A, Broccia G, Corda G, et al. Antilymphocyte globulin, cyclosporin and granulocyte stimulating factor in patients with severe aplastic anemia (SAA): a pilot study of the EBMT SAA working party. Blood 1995;85:1348-53.
10. Bacigalupo A, Piaggio G, Figari O, et al. Response of CFU-GM to increasing doses of rhGM-CSF in patients with AA. Exp Hematol 1991; 19:829-32.
11. Maciejewski PJ, Selleri C, Sato T, Anderson S, Young NS. Increased expression of FAS antigen on bone marrow CD34+ cells of patients with aplastic anemia. Br J Haematol 1995; 91:245-52.
12. Schrezenmeier H, Hertenstein B, Wagner B, Raghavanchar A, Heimpel H. A pathogenetic link between aplastic anemia and paroxysmal nocturnal hemoglobinuria is suggested by a high frequency of aplastic anemia patients with a deficiency of phosphatidyl inositol glycan-anchored proteins. Exp Hematol 1995; 23:81-7.
13. Bacigalupo A, Piaggio G, Podestà M, et al. Collection of peripheral blood hemopoietic progenitors (PBHP) from patients with severe aplastic anemia (SAA) after prolonged administration of granulocyte colony-stimulating factor. Blood 1993; 82:1410-4.
14. Sutherland HJ, Eaves CS, Eaves AC, Dragowska W, Lansdorp PM. Characterization and partial purification of human marrow cells capable of long-term hematopoiesis in vitro. Blood 1992; 74:1563-74.
15. Eaves CJ, Sutherland HJ, Carshman JD, Otsika T, Hogge D. Regulation of primitive human hemopoietic cells in long-term marrow culture. Semin Haematol 1991; 28:126-31.
16. Frazer CC, Szilvassy SJ, Eaves CJ, Humpries RK. Proliferation of totipotent hematopoietic stem cells in vitro with retention of long-term competitive in vivo reconstituting ability. Proc Natl Acad Sci USA 1992; 89:1968-72.
17. Sutherland HJ, Lansdorp PM, Henkelman DH, Eaves AC, Eaves CJ. Functional characterization of individual human hemopoietic stem cells cultured at limiting dilution on supportive marrow stromal layer. Proc Natl Acad Sci USA 1992; 87:3584-8.
18. Tong J, Gordon MS, Srour EF, et al. In vivo administration of recombinant methionyl human Stem Cell Factor expands the number of human marrow hematopoietic stem cells. Blood 1993; 82:784-91.
19. Nakahata T, Ogawa M. Identification in culture of a new class of hematopoietic colony forming units with extreme capability of self-renew and generate multipotential colonies. Proc Natl Acad Sci USA 1992;79:3843-7.
20. Zoumbos NC, Ferris WO, Hsu SM, et al. Analysis of lymphocyte subsets in patients with aplastic anemia. Br J Haematol 1984; 58:95-105.
21. Ruiz-Arguelles GJ, Katzman JA, Greipp PR, Marin-Lopez A, Gonzalez-Llaven J, Cano-Catellanos R. Lymphocyte subsets in patients with aplastic anemia. AmJ Hematol 1984; 16:267-75.
22. Maciejewski JP, Anderson S, Katevas P, Young NS. Phenotypic and functional analysis of bone marrow progenitor cell compartment in bone marrow failure. Br J Haematol 1994; 87:227-31.
23. Roberts AW, Metcalf D. Noncycling state of peripheral blood progenitor cells mobilized by granulocyte colony-stimulating factor and other cytokines. Blood 1995; 86:1600-5.
24. Brodsky RA, Sensebrenner LL, Jones RJ. Complete remission in acquired severe aplastic anemia (SAA) following high-dose cyclophosphamide without bone marrow transplantation (BMT). Blood 1995; 86(Suppl 1):23-9.
25. Torok Storb B, Doney K, Sale G, Thomas ED. In vitro tests for distinguishing possible immune mediated aplastic anemia from transfusion induced sensitization. Blood 1980; 55:2111-8.
26. Carlo Stella C, Tabilio A. Stem cells and stem cell transplantation. Haematologica 1996; 81:573-87.
27. Brenner MK, Rill DR, Moen RC, et al. Gene-marking to trace origin of relapse after autologous bone-marrow transplantation. Lancet 1993; 341:85-6.