메뉴 건너뛰기




Volumn 46, Issue 6, 1997, Pages 625-632

Analysis of the MHC class I antigen presentation machinery in human embryonal carcinomas: Evidence for deficiencies in TAP, LMP and MHC class I expression and their upregulation by IFN-γ

Author keywords

[No Author keywords available]

Indexed keywords

BETA 2 MICROGLOBULIN; GAMMA INTERFERON; HLA ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1;

EID: 0031468363     PISSN: 03009475     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-3083.1997.d01-176.x     Document Type: Article
Times cited : (29)

References (58)
  • 1
    • 0024383535 scopus 로고
    • Antigen recognition by class I-restricted T lymphocytes
    • Townsend A, Bodmer H. Antigen recognition by class I-restricted T lymphocytes. Annu Rev Immunol 1989;7:601-24.
    • (1989) Annu Rev Immunol , vol.7 , pp. 601-624
    • Townsend, A.1    Bodmer, H.2
  • 2
    • 0026764311 scopus 로고
    • Proteolysis, proteasomes and antigen presentation
    • Goldberg AL, Rock KL. Proteolysis, proteasomes and antigen presentation. Nature 1992;357:375-9.
    • (1992) Nature , vol.357 , pp. 375-379
    • Goldberg, A.L.1    Rock, K.L.2
  • 3
    • 0026484826 scopus 로고
    • Cell biology of antigen processing and presentation to MHC class I molecule-restricted T lymphocytes
    • Yewdell JW, Bennink JR. Cell biology of antigen processing and presentation to MHC class I molecule-restricted T lymphocytes. Annu Rev Immunol 1992;52:1-123.
    • (1992) Annu Rev Immunol , vol.52 , pp. 1-123
    • Yewdell, J.W.1    Bennink, J.R.2
  • 4
    • 0025771623 scopus 로고
    • A proteasome-related gene between the two ABC transporter loci in the class II region of the human MHC
    • Glynne R, Powis SH, Beck S, Kelly LA, Kerr I, Trowsdale J. A proteasome-related gene between the two ABC transporter loci in the class II region of the human MHC. Nature 1991;353:357-60.
    • (1991) Nature , vol.353 , pp. 357-360
    • Glynne, R.1    Powis, S.H.2    Beck, S.3    Kelly, L.A.4    Kerr, I.5    Trowsdale, J.6
  • 5
    • 0025998206 scopus 로고
    • Subunit of the '20S' proteasome (multicatalytic proteinase) encoded by the major histocompatibility complex
    • Ortiz-Navarette V, Seelig A, Gernold M, Frentzel S, Kloetzel PM, Hämmerling HG. Subunit of the '20S' proteasome (multicatalytic proteinase) encoded by the major histocompatibility complex. Nature 1991;353:663-5.
    • (1991) Nature , vol.353 , pp. 663-665
    • Ortiz-Navarette, V.1    Seelig, A.2    Gernold, M.3    Frentzel, S.4    Kloetzel, P.M.5    Hämmerling, H.G.6
  • 6
    • 0025646826 scopus 로고
    • Transport protein genes in the murine MHC: Possible implications for antigen processing
    • Monaco JJ, Cho S, Attaya M. Transport protein genes in the murine MHC: possible implications for antigen processing. Nature 1990; 250:1723-6.
    • (1990) Nature , vol.250 , pp. 1723-1726
    • Monaco, J.J.1    Cho, S.2    Attaya, M.3
  • 7
    • 0025604835 scopus 로고
    • A gene in the major histocompatibility complex class I region controlling the class I antigen presentation pathway
    • Spies T, Breshnahan M, Bahram S, Arnold D, Blanck G, Mellins E, Pious D, DeMars R. A gene in the major histocompatibility complex class I region controlling the class I antigen presentation pathway. Nature 1990;348:744-7.
    • (1990) Nature , vol.348 , pp. 744-747
    • Spies, T.1    Breshnahan, M.2    Bahram, S.3    Arnold, D.4    Blanck, G.5    Mellins, E.6    Pious, D.7    DeMars, R.8
  • 8
    • 0025688348 scopus 로고
    • Sequences encoded in the class I region of the MHC related to the 'ABC' superfamily of transporters
    • Trowsdale J, Hanson I, Mockridge I, Beck S, Townsend A, Kelly A. Sequences encoded in the class I region of the MHC related to the 'ABC' superfamily of transporters. Nature 1990;348:741-4.
    • (1990) Nature , vol.348 , pp. 741-744
    • Trowsdale, J.1    Hanson, I.2    Mockridge, I.3    Beck, S.4    Townsend, A.5    Kelly, A.6
  • 10
    • 0027239749 scopus 로고
    • Selective and ATP-dependent translocation of peptides by MHC-encoded transporter
    • Neefjes JJ, Momburg F, Hämmerling HG. Selective and ATP-dependent translocation of peptides by MHC-encoded transporter. Science 1993;261:769-71.
    • (1993) Science , vol.261 , pp. 769-771
    • Neefjes, J.J.1    Momburg, F.2    Hämmerling, H.G.3
  • 11
    • 0027715856 scopus 로고
    • Peptide translocation by variants of the transporter associated with antigen processing
    • Heemels MT, Schumacher TNM, Wonigeit K, Ploegh HL. Peptide translocation by variants of the transporter associated with antigen processing. Science 1993;262:2059-63.
    • (1993) Science , vol.262 , pp. 2059-2063
    • Heemels, M.T.1    Schumacher, T.N.M.2    Wonigeit, K.3    Ploegh, H.L.4
  • 13
    • 0026607979 scopus 로고
    • An endogenous antigenic peptide bypasses the class I antigen presentation defect in RMA-S
    • Hosken NA, Bevan MJ. An endogenous antigenic peptide bypasses the class I antigen presentation defect in RMA-S. J Exp Med 1992; 175:719-23.
    • (1992) J Exp Med , vol.175 , pp. 719-723
    • Hosken, N.A.1    Bevan, M.J.2
  • 16
    • 0028107066 scopus 로고
    • Presentation of viral antigens restricted by H-2Kb, Db or Kd in proteasome subunit LMP-2 and LMP-7 deficient cells
    • Zhou X, Momburg F, Liu T, Abdel-Motal UM, Jondal M, Hämmerling GJ, Ljunggren HG. Presentation of viral antigens restricted by H-2Kb, Db or Kd in proteasome subunit LMP-2 and LMP-7 deficient cells. Eur J Immunol 1994;24:1863-8.
    • (1994) Eur J Immunol , vol.24 , pp. 1863-1868
    • Zhou, X.1    Momburg, F.2    Liu, T.3    Abdel-Motal, U.M.4    Jondal, M.5    Hämmerling, G.J.6    Ljunggren, H.G.7
  • 17
    • 0025845432 scopus 로고
    • Restored expression of major histocompatibility class I molecules by gene transfer of a putative peptide transporter
    • Spies T, DeMars R. Restored expression of major histocompatibility class I molecules by gene transfer of a putative peptide transporter. Nature 1991;351:323-4.
    • (1991) Nature , vol.351 , pp. 323-324
    • Spies, T.1    DeMars, R.2
  • 19
    • 0026054898 scopus 로고
    • Modulation of MHC antigen expression by viruses and oncogenes
    • Mausdley DJ, Pond JS. Modulation of MHC antigen expression by viruses and oncogenes. Immunol Today 1991;12:429-31.
    • (1991) Immunol Today , vol.12 , pp. 429-431
    • Mausdley, D.J.1    Pond, J.S.2
  • 21
    • 0029057043 scopus 로고
    • Loss of HLA class I antigens by melanoma cells: Molecular mechanisms, functional significance and clinical relevance
    • Ferrone S, Marincola FM. Loss of HLA class I antigens by melanoma cells: molecular mechanisms, functional significance and clinical relevance. Immunol Today 1995;16:487-94.
    • (1995) Immunol Today , vol.16 , pp. 487-494
    • Ferrone, S.1    Marincola, F.M.2
  • 24
    • 0024958330 scopus 로고
    • Post-transcriptional downregulation of MHC class I expression in oncogene-transformed cells is reverted by IFN-alpha and -gamma
    • Seliger B, Pfizenmaier K. Post-transcriptional downregulation of MHC class I expression in oncogene-transformed cells is reverted by IFN-alpha and -gamma. J Immunogenet 1989;16:315-20.
    • (1989) J Immunogenet , vol.16 , pp. 315-320
    • Seliger, B.1    Pfizenmaier, K.2
  • 26
    • 0028318838 scopus 로고
    • Downregulation of peptide transporter genes in cell lines transformed with highly oncogenic adenovirus 12
    • Rotem-Yeduhar R, Winograd S, Sela S, Coligan JE, Ehrlich R. Downregulation of peptide transporter genes in cell lines transformed with highly oncogenic adenovirus 12. J Exp Med 1994; 180:477-88.
    • (1994) J Exp Med , vol.180 , pp. 477-488
    • Rotem-Yeduhar, R.1    Winograd, S.2    Sela, S.3    Coligan, J.E.4    Ehrlich, R.5
  • 28
    • 0026468645 scopus 로고
    • Cytokines increase transporter in antigen processing-1 expression more rapidly than HLA class I expression in endothelial cells
    • Epperson DE, Arnold D, Spies T, Cresswell P, Pober JS, Johnson DR. Cytokines increase transporter in antigen processing-1 expression more rapidly than HLA class I expression in endothelial cells. J Immunol 1992;149:3297-301.
    • (1992) J Immunol , vol.149 , pp. 3297-3301
    • Epperson, D.E.1    Arnold, D.2    Spies, T.3    Cresswell, P.4    Pober, J.S.5    Johnson, D.R.6
  • 29
    • 0026728649 scopus 로고
    • Proteasomes are regulated by Interferon-γ: Implications for antigen processing
    • Yang Y, Waters JB, Früh K, Pettersson PA. Proteasomes are regulated by Interferon-γ: Implications for antigen processing. Proc Natl Acad Sci USA 1992;89:4928-32.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 4928-4932
    • Yang, Y.1    Waters, J.B.2    Früh, K.3    Pettersson, P.A.4
  • 30
    • 0030964320 scopus 로고    scopus 로고
    • IFN-g mediated coordinated transcriptional regulation of the human TAP-1 and LMP-2 genes in human renal cell carcinoma
    • Seliger B, Hammers S, Höhne A, Zeidler R, Knuth A, Gerharz CD, Huber C. IFN-g mediated coordinated transcriptional regulation of the human TAP-1 and LMP-2 genes in human renal cell carcinoma. Clin Cancer Res 1997;3:573-8.
    • (1997) Clin Cancer Res , vol.3 , pp. 573-578
    • Seliger, B.1    Hammers, S.2    Höhne, A.3    Zeidler, R.4    Knuth, A.5    Gerharz, C.D.6    Huber, C.7
  • 32
    • 0019846377 scopus 로고
    • The expression of MHC antigens by human teratocarcinoma derived cell lines
    • Andrews PW, Bronson DL, Wiles MV, Goodfellow P. The expression of MHC antigens by human teratocarcinoma derived cell lines. Tissue Antigens 1981;17:493-500.
    • (1981) Tissue Antigens , vol.17 , pp. 493-500
    • Andrews, P.W.1    Bronson, D.L.2    Wiles, M.V.3    Goodfellow, P.4
  • 33
    • 0022916563 scopus 로고
    • Negative regulation of the major histocompatibility class I gene in undifferentiated embryonal carcinoma cells
    • Miyazaki JI, Appella E, Ozato K. Negative regulation of the major histocompatibility class I gene in undifferentiated embryonal carcinoma cells. Proc Natl Acad Sci USA 1986;83:9537-41.
    • (1986) Proc Natl Acad Sci USA , vol.83 , pp. 9537-9541
    • Miyazaki, J.I.1    Appella, E.2    Ozato, K.3
  • 34
    • 0023762160 scopus 로고
    • Establishment of cell lines from somite stage mouse embryos and expression of major histocompatibility complex class I genes in these cells
    • Silverman T, Rein A, Orrison B, Langloss B, Bratthauer G, Miyazaki JI, Ozato K. Establishment of cell lines from somite stage mouse embryos and expression of major histocompatibility complex class I genes in these cells. J Immunol 1988;140:4378-87.
    • (1988) J Immunol , vol.140 , pp. 4378-4387
    • Silverman, T.1    Rein, A.2    Orrison, B.3    Langloss, B.4    Bratthauer, G.5    Miyazaki, J.I.6    Ozato, K.7
  • 35
    • 0027525495 scopus 로고
    • Immunological paradox in testicular tumors: The presence of a large number of activated T-cells despite the complete absence of MHC antigens
    • Noun AME, Hussain RF, Oliver TD, Handy AM, Bartkova I, Bodmer JG. Immunological paradox in testicular tumors: the presence of a large number of activated T-cells despite the complete absence of MHC antigens. Eur J Cane 1993;13:1895-9.
    • (1993) Eur J Cane , vol.13 , pp. 1895-1899
    • Noun, A.M.E.1    Hussain, R.F.2    Oliver, T.D.3    Handy, A.M.4    Bartkova, I.5    Bodmer, J.G.6
  • 36
    • 0021184542 scopus 로고
    • Regulated expression of an introduced MHC H-2Kbm1 gene in murine embryonal carcinoma cells
    • Rosenthal SA, Wright S, Cedar H, Flavell RA, Grosveld F. Regulated expression of an introduced MHC H-2Kbm1 gene in murine embryonal carcinoma cells. Nature 1984;310:415-18.
    • (1984) Nature , vol.310 , pp. 415-418
    • Rosenthal, S.A.1    Wright, S.2    Cedar, H.3    Flavell, R.A.4    Grosveld, F.5
  • 37
    • 0027452408 scopus 로고
    • Retinoic acid induction of major histocompatibility complex class I genes in NTera-2 embryonal carcinoma cells involves induction of NF-κB (p50-p65) and retinoic acid receptor β-retinoid X receptor heterodimers
    • Segars JH, Nagata T, Bours V, Medin JA, Franzozo G, Blanco JC, Drew P, Becker K, An J, Tang T, Stephany DA, Neel B, Siebenlist U, Ozato K. Retinoic acid induction of major histocompatibility complex class I genes in NTera-2 embryonal carcinoma cells involves induction of NF-κB (p50-p65) and retinoic acid receptor β-retinoid X receptor heterodimers. Mol Cell Biol 1993;13:6157-69.
    • (1993) Mol Cell Biol , vol.13 , pp. 6157-6169
    • Segars, J.H.1    Nagata, T.2    Bours, V.3    Medin, J.A.4    Franzozo, G.5    Blanco, J.C.6    Drew, P.7    Becker, K.8    An, J.9    Tang, T.10    Stephany, D.A.11    Neel, B.12    Siebenlist, U.13    Ozato, K.14
  • 38
    • 0025162937 scopus 로고
    • Absence of the type I INF system in EC cells: Transcriptional activator (IRF-1) and repressor (IRF-2) genes are developmentally regulated
    • Harada H, Willison J, Sukakibara J, Miyamoto M, Fujita T, Taniguchi T. Absence of the type I INF system in EC cells: transcriptional activator (IRF-1) and repressor (IRF-2) genes are developmentally regulated. Cell 1990;63:303-12.
    • (1990) Cell , vol.63 , pp. 303-312
    • Harada, H.1    Willison, J.2    Sukakibara, J.3    Miyamoto, M.4    Fujita, T.5    Taniguchi, T.6
  • 39
    • 0022570876 scopus 로고
    • Terato-carcinoma cell MHC antigen expression is regulated in vitro by a soluble noninterferon factor
    • Ostrand-Rosenberg S, Schwartzman ML, Hecht TT, Marr L. Terato-carcinoma cell MHC antigen expression is regulated in vitro by a soluble noninterferon factor. Cell Immunol 1986;99:453-60.
    • (1986) Cell Immunol , vol.99 , pp. 453-460
    • Ostrand-Rosenberg, S.1    Schwartzman, M.L.2    Hecht, T.T.3    Marr, L.4
  • 40
    • 0021835634 scopus 로고
    • Mouse major histocompatibility class 1 gene expression begins at the midsomite stage and is inducible in earlier stage embryos by interferon
    • Ozato K, Wan L, Orsin B. Mouse major histocompatibility class 1 gene expression begins at the midsomite stage and is inducible in earlier stage embryos by interferon. Proc Natl Acad Sci USA 1985; 82:2427-31.
    • (1985) Proc Natl Acad Sci USA , vol.82 , pp. 2427-2431
    • Ozato, K.1    Wan, L.2    Orsin, B.3
  • 41
    • 0026051720 scopus 로고
    • MHC class I surface expression in embryo-derived cell lines inducible with peptide or Interferon
    • Bikoff E, Jaffe L, Ribaudo RK, Otten GR, Germain RN, Robertson EJ. MHC class I surface expression in embryo-derived cell lines inducible with peptide or Interferon. Nature 1991a;354:235-8.
    • (1991) Nature , vol.354 , pp. 235-238
    • Bikoff, E.1    Jaffe, L.2    Ribaudo, R.K.3    Otten, G.R.4    Germain, R.N.5    Robertson, E.J.6
  • 42
    • 0025887792 scopus 로고
    • Defective assembly of class 1 major histocompatibility complex molecules in an embryonic cell line
    • Bikoff EK, Otten GR, Robertson EJ. Defective assembly of class 1 major histocompatibility complex molecules in an embryonic cell line. Eur J Immunol 1991;21:1997-2004.
    • (1991) Eur J Immunol , vol.21 , pp. 1997-2004
    • Bikoff, E.K.1    Otten, G.R.2    Robertson, E.J.3
  • 43
    • 0027818397 scopus 로고
    • Differential effect of human and mouse beta-2-microglobulin on the induction and the antigenic profile of endogenous HLA-A and -B antigens synthesized by beta-2-microgobulin gen-null melanoma cells
    • Wang Z, Hu X, Tatake RJ, Yang SY, Zeff RA, Ferrone S. Differential effect of human and mouse beta-2-microglobulin on the induction and the antigenic profile of endogenous HLA-A and -B antigens synthesized by beta-2-microgobulin gen-null melanoma cells. Cancer Res 1993;53:4302-9.
    • (1993) Cancer Res , vol.53 , pp. 4302-4309
    • Wang, Z.1    Hu, X.2    Tatake, R.J.3    Yang, S.Y.4    Zeff, R.A.5    Ferrone, S.6
  • 44
    • 0018849459 scopus 로고
    • A comparative study of eight cell lines derived from human testicular teratocarcinoma
    • Andrews PW, Bronson DJ, Benham F, Strickland S, Knowles BB. A comparative study of eight cell lines derived from human testicular teratocarcinoma. Int J Cancer 1980;26:269-80.
    • (1980) Int J Cancer , vol.26 , pp. 269-280
    • Andrews, P.W.1    Bronson, D.J.2    Benham, F.3    Strickland, S.4    Knowles, B.B.5
  • 45
    • 0026566332 scopus 로고
    • The antigen-processing mutant T2 suggests a role for MHC-linked genes in class II antigen presentation
    • Riberdy JM, Cresswell P. The antigen-processing mutant T2 suggests a role for MHC-linked genes in class II antigen presentation. J Immunol 1992;148:2586-90.
    • (1992) J Immunol , vol.148 , pp. 2586-2590
    • Riberdy, J.M.1    Cresswell, P.2
  • 46
    • 0022317963 scopus 로고
    • Host resistance directed selectively against H2 deficient lymphoma variants
    • Ljunggren HG, Kärre K. Host resistance directed selectively against H2 deficient lymphoma variants. J Exp Med 1985;162:1745-59.
    • (1985) J Exp Med , vol.162 , pp. 1745-1759
    • Ljunggren, H.G.1    Kärre, K.2
  • 47
    • 0026595367 scopus 로고
    • Alternative exon usage and processing of the major histocompatibility complex-encoded proteasome subunits
    • Früh K, Yang Y, Arnolds D, Chambers J, Wu L, Waters JB, Spies T, Peterson PA. Alternative exon usage and processing of the major histocompatibility complex-encoded proteasome subunits. J Biol Chem 1992;267:22131-4.
    • (1992) J Biol Chem , vol.267 , pp. 22131-22134
    • Früh, K.1    Yang, Y.2    Arnolds, D.3    Chambers, J.4    Wu, L.5    Waters, J.B.6    Spies, T.7    Peterson, P.A.8
  • 48
    • 0021759199 scopus 로고
    • Evolutionary conservation in the untranslated regions of actin mRNAs: DNA sequence of a human beta-actin cDNS
    • Ponte P, Ng S, Engel J, Gunning P, Kedes L. Evolutionary conservation in the untranslated regions of actin mRNAs: DNA sequence of a human beta-actin cDNS. Nucl Acids Res 1984;12: 1687-96.
    • (1984) Nucl Acids Res , vol.12 , pp. 1687-1696
    • Ponte, P.1    Ng, S.2    Engel, J.3    Gunning, P.4    Kedes, L.5
  • 49
    • 0021919448 scopus 로고
    • Cloning and complete sequence of an HLA-A2 gene: Analysis of two HLA-A alleles at the nucleotide level
    • Koller BH, Orr HT. Cloning and complete sequence of an HLA-A2 gene: analysis of two HLA-A alleles at the nucleotide level. J Immunol 1985;134:2727-33.
    • (1985) J Immunol , vol.134 , pp. 2727-2733
    • Koller, B.H.1    Orr, H.T.2
  • 50
    • 0018639079 scopus 로고
    • Isolation of biological active ribonucleic acid from sources enriched in ribonuclease
    • Chirgwin JM, Przybyla AA, MacDonald RJ, Rutter WJ. Isolation of biological active ribonucleic acid from sources enriched in ribonuclease. Biochem 1979;18:5294-9.
    • (1979) Biochem , vol.18 , pp. 5294-5299
    • Chirgwin, J.M.1    Przybyla, A.A.2    MacDonald, R.J.3    Rutter, W.J.4
  • 51
    • 0018308181 scopus 로고
    • Characterization of a monoclonal antibody and its use in the genetic and biochemical analysis of major histocompatibility antigens
    • Brodsky FM, Parham P, Barn JC, Crumpton MJ, Bodmer WF. Characterization of a monoclonal antibody and its use in the genetic and biochemical analysis of major histocompatibility antigens. Eur J Immunol 1979;9:536-45.
    • (1979) Eur J Immunol , vol.9 , pp. 536-545
    • Brodsky, F.M.1    Parham, P.2    Barn, J.C.3    Crumpton, M.J.4    Bodmer, W.F.5
  • 52
    • 0028110959 scopus 로고
    • Functional expression and purification of the ABC transporter complex associated with antigen processing (TAP) in insect cells
    • Meyer TH, van Endert PM, Uebel S, Ehring B, Tainpé R. Functional expression and purification of the ABC transporter complex associated with antigen processing (TAP) in insect cells. FEBS Lett 1994;351:443-7.
    • (1994) FEBS Lett , vol.351 , pp. 443-447
    • Meyer, T.H.1    Van Endert, P.M.2    Uebel, S.3    Ehring, B.4    Tainpé, R.5
  • 53
    • 0026635044 scopus 로고
    • Immunohistochemical and biochemical characterisation of the expression of a human embryonal carcinoma cell proleoglycan antigen in human germ cell tumors and other tissues
    • Mason MD, Pera MF. Immunohistochemical and biochemical characterisation of the expression of a human embryonal carcinoma cell proleoglycan antigen in human germ cell tumors and other tissues. Eur J Cancer 1992;28:1090-8.
    • (1992) Eur J Cancer , vol.28 , pp. 1090-1098
    • Mason, M.D.1    Pera, M.F.2
  • 55
    • 0028358733 scopus 로고
    • Peptide transporter independent, stress protein mediated endosomal processing of endogenous protein antigens for major histocompatibility complex class I presentation
    • Schirmbeck R, Reimann J. Peptide transporter independent, stress protein mediated endosomal processing of endogenous protein antigens for major histocompatibility complex class I presentation. Eur J Immunol 1994;24:1478-83.
    • (1994) Eur J Immunol , vol.24 , pp. 1478-1483
    • Schirmbeck, R.1    Reimann, J.2
  • 57
    • 0028927841 scopus 로고
    • Coordinate regulation of the human TAP-1 and LMP-2 genes from a shared bidirectional promoter
    • Wright KL, White LC, Kelly A, Beck S, Trowsdale J, Ting JPY. Coordinate regulation of the human TAP-1 and LMP-2 genes from a shared bidirectional promoter. J Exp Med 1995;181:1459-71.
    • (1995) J Exp Med , vol.181 , pp. 1459-1471
    • Wright, K.L.1    White, L.C.2    Kelly, A.3    Beck, S.4    Trowsdale, J.5    Ting, J.P.Y.6
  • 58
    • 0027214605 scopus 로고
    • Interferon-gamma and expression of MHC genes regulate peptide hydrolysis by proteasomes
    • Gaczynska M, Rock KL, Goldberg AL. Interferon-gamma and expression of MHC genes regulate peptide hydrolysis by proteasomes. Nature 1993;365:264-7.
    • (1993) Nature , vol.365 , pp. 264-267
    • Gaczynska, M.1    Rock, K.L.2    Goldberg, A.L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.