Cardiovascular T-type calcium channels: Physiological and pharmacological significance

Journal of Hypertension, Supplement

Volumn 15, Issue 5, 1997, Pages

  Triggle, David J ^a  

^a UNIVERSITY AT BUFFALO   (United States)

Author keywords

Calcium antagonists; Calcium channels; L channels; Mibefradil; Ro 40 5967; T channels; Voltage gated calcium channels

Indexed keywords

CALCIUM ANTAGONIST; CALCIUM CHANNEL; DILTIAZEM; MIBEFRADIL; NIFEDIPINE; VERAPAMIL;

CALCIUM HOMEOSTASIS; CARDIOVASCULAR SYSTEM; CONFERENCE PAPER; HEART ELECTROPHYSIOLOGY; HEART PROTECTION; HEART RATE; HUMAN; PACEMAKER; PHARMACOLOGY; PHYSIOLOGY; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; VASODILATATION;

ANIMALS; BENZIMIDAZOLES; CALCIUM; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS; CARDIOVASCULAR SYSTEM; HUMANS; MIBEFRADIL; TETRAHYDRONAPHTHALENES;

EID: 0031468191     PISSN: 09521178     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (59)

1. Campbell AK: Intracellular Calcium: Its Role As A Regulator. New York: Wiley and Sons; 1983.
2. 2+ signaling in the cardiovascular system. Am J Cardiol 1996, 78 (suppl 9A):2-6.
3. Hartman AW, Maxwell MJ: An evaluation of the role of calcium in cell injury. Annu Rev Pharmacol Toxicol 1995, 35:129-144.
4. Triggle DJ: Drugs affecting calcium regulation and actions. In Textbook of Pharmacology. Edited by Smith CM, Reynard AW. Philadelphia: Saunders; 1991:453-478.
5. Resnick LM: Calciotropic hormones in salt-sensitive essential hypertension: 1,25-dihydroxyvitamin D and parathyroid hypertensive factor. J Hypertens 1994, 12 (suppl 1):S3-S9.
6. Triggle DJ: Mechanisms of action of calcium antagonists. In Calcium Antagonists in Clinical Medicine, 2nd edn. Edited by Epstein M. Philadelphia: Hanley and Belfus; in press.
7. 2+ release channels. Trends Pharmacol Sci 1994, 15:145-149.
8. Carafoli E, Guerini D: Molecular and cellular biology plasma membrane calcium ATPase. Trends Cardiovasc Med 3:177-184.
9. Marks AR: Expression and regulation of ryanodine receptor/calcium release channels. Trends Cardiovasc Med 1996, 6:130-136.
10. 2+ in smooth muscle. Annu Rev Physiol 1989, 51:315-329.
11. Hughes AD: Calcium channels in vascular smooth muscle cells. J Vasc Res 1995, 32:353-370.
12. Catterall WA: Structure and function of voltage-gated ion channels. Annu Rev Biochem 1995, 64:493-531.
13. Babbedge R, Mead A (eds): Receptor and ion channel nomenclature, 8th edn. Trends Pharmacol Sci 1997, 18 (suppl 8):1-83.
14. Perez-Reyes E, Schneider T: Molecular biology of calcium channels. Kidney Int 1995, 48:1111-1124.
15. 2+ channel diversity. Annu Rev Neurosci 1994, 17:399-418.
16. DeWaard M, Gurnett CA, Campbell KP: Structural and functional diversity of voltage-gated calcium channels. In Ion Channels. Edited by Narahashi T. New York: Plenum Press; 1996, 4:41-87.
17. Mori Y, Mikala G, Varadi G, et al.: Molecular pharmacology of voltage-dependent calcium channels. Jpn J Pharmacol 1996, 72:83-109.
18. Hockerman GH, Peterson BZ, Johnson BD, Catterall WA: Molecular determinants of drug binding and action on L-type calcium channels. Annu Rev Pharmacol Toxicol 1997, 37:361-396.
19. 2+ channel regulation by a conserved β-subunit domain. Neuron 1994, 13:495-503.
20. Gurnett CA, Campbell KP: Transmembrane auxiliary subunits of voltage-dependent ion channels. J Biol Chem 1996, 271:27975-27978.
21. Llinas R: The Intrinsic electrophysiological properties of mammalian neurons: insights into central nervous system function. Science 1988, 242:1654-1664.
22. Johnston D, Fisher R, Gray R: Voltage-gated calcium channels in adult hippocampal neurons. In Ion Channels. Edited by Narahashi T. New York: Plenum Press; 1993, 3:39-62.
23. Miljanich GP, Ramachandran J: Antagonists of neuronal calcium channels: structure, function and therapeutic implications. Annu Rev Pharmacol Toxicol 1995, 35:707-734.
24. Nowycky MC, Fox AP, Tsien RW: Three types of neuronal calcium channels with different calcium agonist sensitivity. Nature 1985, 316:440-443.
25. Bean BP: Classes of calcium channels in vertebrate cells. Annu Rev Physiol 1989, 51:367-384.
26. 2+ channels. Trends Pharmacol Sci 1997, 18:37-42.
27. Katz AM: Calcium channel diversity in the cardiovascular systems. J Am Coll Cardiol 1996, 28:522-529.
28. 2+ channels and their possible counterparts in mammalian CNS neurons. Neuropharmacology 1993, 32:1075-1088.
29. Tsien RW, Tsien RY: Calcium channels, stores and oscillations. Annu Rev Cell Biol 1990, 6:715-760.
30. Bogdanov KY, Ziman BD, Spurgeon HA, Lakatta EG: L- and T-type calcium currents differ in finch and rat ventricular cardiomyocytes. J Mol Cell Cardiol 1995, 27:2581-2593.
31. 2+ channels in guinea-pig heart cells. J Physiol 1992, 456:247-265.
32. Quinn SJ, Cornwall MC, Williams GH: Electrophysiological responses to angiotensin II of isolated rat adrenal glomerulosa cells. Endocrinology 1987, 120:1581-1589.
33. Barrett PQ, Isales CM, Bollag WB, McCarthy RT: Calcium channels and aldosterone secretion: modulation by potassium and atrial natriuretic peptide. Am J Physiol 1991, 30:F706-F719.
34. McCarthy RT, Isales C, Rasmussen H: T-type calcium channels in adrenal glomerulosa cells: GTP-dependent modulation by angiotensin II. Proc Natl Acad Sci USA 1993, 30:3260-3264.
35. 2+ Channels. Edited by Clozel J-P, Nargeot J, Tsien RW. Chester, UK: Adis International; 1997 (in press).
36. 2+ current blocker in single heart cells. Am J Physiol 1992, 262:H463-H471.
37. Xu X, Best PM: Postnatal changes in T-type calcium current density in rat atrial myocytes. J Physiol 1992, 454:657-672.
38. Xu X, Best PM: Increase in T-type calcium current in atrial myocytes from adult rats with growth hormone secreting tumors. Proc Natl Acad Sci USA 1990, 87:4655-4659.
39. 2+ channels are abnormal in genetically determined cardiomyopathic hamster hearts. Circ Res 1994, 75:149-155.
40. 2+ current is expressed in hypertrophied adult feline left ventricular myocytes. Circ Res 1993, 73:777-782.
41. Furukawa T, Ito H, Nitta J, et al.: Endothelin-I enhances calcium entry through T-type calcium channels in cultured neonatal rat ventricular myocytes. Circ Res 1992, 71:1242-1253.
42. 2+ influx via T-type channels modulates PDGF-induced replication of mouse fibroblasts. Am J Physiol 1993, 265:C1239-C1246.
43. Triggle DJ, Hawthon M, Gopalakrishnan M, et al.: Synthetic organic ligands active at voltage-gated calcium channels. Ann NY Acad Sci 1991, 635:123-138.
44. Cohen CJ, Spires S, VanSkiver D: Block of T-type Ca channels in guinea pig atrial cells by antiarrhythmic agents and Ca channel antagonists. J Gen Physiol 1992, 100:703-728.
45. 2+ currents in atrial myocytes. Pflugers Arch 1992, 420:410-412.
46. Liu Q-Y, Karpinski E, Pang PKT: Tetrandrine inhibits both T and L calcium channel currents in ventricular cells. J Cardiovasc Pharmacol 1992, 20:513-519.
47. 2+ channels in rat aorta smooth muscle cells in primary culture. Circ Res 1990, 67:469-480.
48. Takahashi K, Ataike N: Calcium antagonist effects on low-threshold (T-type) calcium current in rat isolated hippocampal in CA1 pyramidal neurons. J Pharmacol Exp Ther 1991, 256:169-175.
49. Wang R, Karpinski E, Wu L, Pang PKT: Flunarizine selectively blocks transient calcium channel currents in NIE-115 cells. J Pharmacol Exp Ther 1990, 254:1006-1010.
50. Tang C-M, Presser F, Morad M: Amiloride selectively blocks the low threshold (T) calcium channel. Science 1988, 240:213-215.
51. Enyeart JJ, Biagi BA, Mlinar B: Preferential block of T-type calcium channels by neuroleptics in neural crest-derived rat and human C cell lines. Mol Pharmacol 1992, 42:364-372.
52. Triggle DJ: Pharmacologic and therapeutic differences among calcium antagonists: profile of mibefradil, a new calcium antagonist. Am J Cardiol 1996, 78 (suppl 9A):7-12.
53. Clozel J-P, Osterrieder W, Kleinbloesem CH, et al.: Ro 40-5967: a new nondihydropyridine calcium antagonist Cardiovasc Drug Rev 1991, 9:4-17.
54. 2+ channel in cardiac tissue. Eur J Pharmacol 1995, 280:155-158.
55. 2+ channels by Ro 40-5967. Circ Res 1994, 75:144-148.
56. 2+ channel antagonist mibefradil (Ro 40-5967). Mol Pharmacol 1995, 48:540-549.
57. 2+ channels. J Pharmacol Exp Ther 1994, 271:1483-1488.
58. Schmitt R, Clozel J-P, Iberg N, Bühler FR: Mibefradil prevents neointima formation of vascular injury in rats. Arterioscler Thromb Vasc Biol 1995, 15:1161-1165.
59. Gray GA, Clozel M, Clozel J-P, Baumgartner H-R: Effects of calcium channel blockage on the aortic intima in spontaneously hypertensive rats. Hypertension 1993, 22:569-576.