Noninvasive procedure for in situ determination of skin surface aspartic proteinase activity in animals; Implications for human skin

Archives of Dermatological Research

Volumn 289, Issue 12, 1997, Pages 686-691

  Wormser, Uri ^a   Kohen, Ron ^a   Moor, Eldad Victor ^b   Eldad, Arie ^b   Gal, Rivka ^c   Nyska, Abraham ^d   Brodsky, Berta ^a  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^b HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

^c RABIN MEDICAL CENTER   (Israel)

^d HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

Aspartic proteinase; Cathepsin D; Skin

Indexed keywords

ASPARTIC PROTEINASE; CATHEPSIN D; CATHEPSIN E; CHLORMETHINE; INSULIN DERIVATIVE; IODINE 125; PEPSTATIN; PROPYLENE GLYCOL; TRICHLOROACETIC ACID;

AGING; ANIMAL EXPERIMENT; ARTICLE; ENZYME ACTIVITY; ENZYME LOCALIZATION; EPIDERMIS; GUINEA PIG; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; ISOTOPE LABELING; NONHUMAN; PRIORITY JOURNAL; SKIN SURFACE; STRATUM CORNEUM;

AGING; ALKYLATING AGENTS; ANIMALS; ASPARTIC ENDOPEPTIDASES; CATHEPSIN D; ENZYME INHIBITORS; GUINEA PIGS; HUMANS; IMMUNOHISTOCHEMISTRY; IRRITANTS; MECHLORETHAMINE; PROPYLENE GLYCOL; RATS; SKIN;

EID: 0031467784     PISSN: 03403696     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004030050262     Document Type: Article

References (34)

1. Alkemade HA, Vlijmen-Willems IM van, Haelst UJ van, Kerkhof PC van de, Schalkwijk J (1994) Demonstration of skin-derived antileukoproteinase (SKALP) and its target enzyme human leukocyte elastase in squamous cell carcinoma. J Pathol 174: 121-129
2. Brysk MM, Bell T, Brysk H, Selvanayagam P, Rajaraman S (1994) Enzymatic activity of desquamin. Exp Cell Res 214: 22-26
3. Dreno B, Trossaert M, Boiteau HL, Litoux P (1992) Changes in cutaneous zinc during skin aging. Ann Dermatol Venereol 119: 263-266
4. Duffy MJ, Brouillet J-P, Reilly D, McDermott E, O'Higgins N, Fennelly JJ (1991) Cathepsin D concentrations in breast cancer cytosols: correlation with biochemical, histological and clinical findings. Clin Chem 37 : 101-104
5. Egelrud T, Regnier M, Sondell B, Shroot B, Schmidt R (1993) Expression of stratum corneum chymotryptic enzyme in reconstructed human epidermis and its suppression by retinoic acid. Acta Derm Venereol 73 : 181-184
6. Fraki JE, Hopsu-Havu VK (1976) Human skin proteases. Fractionation of psoriasis scale proteases and separation of a plasminogen activator and a histone hydrolysing protease. Arch Dermatol Res 256 : 113-126
7. Hansson L, Stromqvist M, Backman A, Wallbrandt P, Carlstein A, Egelrud T (1994) Cloning, expression, and characterization of stratum corneum chymotryptic enzyme. A skin-specific human serine proteinase. J Biol Chem 269 : 19420-19426
8. Hara K, Fukuyama K, Sakai H, Yamamoto K, Epstein WL (1993) Purification and immunohistochemical localization of aspartic proteinases in rat epidermis. J Invest Dermatol 100:394-399
9. Heikkinen JE, Jarvinen M, Jansen CR (1975) Purification and biochemical characterization of rat skin cathepsin D. J Invest Dermatol 65 : 272-278
10. Jasani B, Jasani MK, Talbot MD (1978) Characterization of two acid proteinases found in rabbit skin homografts. Biochem J 169 : 287-295
11. Kantsaliev AL, Kozyreva EA, Kushlinskii NE, Rottenberg VI, Klimenkov AA, Vasil'ev AV (1994a) Cathepsin D activity in gastric cancer. Vopr Onkol 40 : 40-46
12. Kantsaliev AL, Kushlinskii NE, Vasil'ev AV, Klimenkov AA (1994b) Proteolytic enzyme activity in stomach cancer patients with various prognoses. Vopr Med Khim 40 : 41-43
13. Kawada A, Hara K, Morimoto K, Hiruma M, Ishibashi A (1995) Rat epidermal cathepsin B: purification and characterization of proteolytic properties toward filaggrin and synthetic substrates. Int J Biochem Cell Biol 27 : 175-183
14. Kenny AJ (1977) Proteinases associated with cell membranes. In: Barrett AJ (ed) Proteinases in mammalian cells and tissues. Elsevier, Holland, pp 393-444
15. Kohler U, Langanke D, Sorger D, Martin R, Bilek K (1995) The prognostic value of cathepsin D in endometrial carcinoma. Zentralbl Gynakol 117 : 148-152
16. Kramer MD, Schaefer B, Reinartz J (1995) Plasminogen activation by human keratinocytes: molecular pathways and cell-biological consequences. Biol Chem Hoppe Seyler 376:131-141
17. Lazarus SL, Poole AR (1975) Immunocytochemical localization of cathepsin D in rabbit skin. Arch Dermatol 111 : 1150-1153
18. Lundstrom A, Egelrud T (1991) Stratum corneum chymotryptic enzyme: a proteinase which may be generally present in the stratum corneum and with a possible involvement in desquamation. Acta Derm Venereol 71 : 471-474
19. Mansour EG, Ravdin PM, Dressler L (1994) Prognostic factors in early breast carcinoma. Cancer 74[Suppl 1] : 381-400
20. Mestre-Deharo C, Sayang J (1991) Histologic signs of cutaneous aging. Rev Fr Gynecol Obstet 86 : 425-432
21. Mier PD, Hurk JJ van den (1975) Lysosomal hydrolases of the epidermis. 3. Peptide hydrolases. Br J Dermatol 93 : 509-517
22. Miyachi Y, Yoshimura N, Suzuki S, Hamakubo T, Kannagi R, Imamura S, Murachi T (1986) Biochemical demonstration and immunohistochemical localization of calpain in human skin. J Invest Dermatol 86 : 346-349
23. Nakopoulou L, Lazaris AC, Baltas D, Giannopoulou I, Kavantzas N, Tzonou A (1995) Prognostic evaluation of oestrogen-regulated protein immunoreactivity in ductal invasive (NOS) breast cancer. Virchows Arch 427 : 33-40
24. Nazeer T, Malfetano JH, Rosano TG, Ross JS (1992) Correlation of tumor cytosol cathepsin D with differentiation and invasiveness of endometrial adenocarcinoma. Am J Clin Pathol 97 : 764-769
25. Skytt A, Stromqvist M, Egelrud T (1995) Primary substrate specificity of recombinant human stratum corneum chymotryptic enzyme. Biochem Biophys Res Commun 211 : 586-589
26. Sondell B, Thornell LE, Stigbrand T, Egelrud T (1994) Immunolocalization of stratum corneum chymotryptic enzyme in human skin and oral epithelium with monoclonal antibodies: evidence of a proteinase specifically expressed in keratinizing squamous epithelia. J Histochem Cytochem 42 : 459-465
27. Sondell B, Thornell LE, Egelrud T (1995) Evidence that stratum corneum chymotryptic enzyme is transported to the stratum corneum extracellular space via lamellar bodies. J Invest Dermatol 104 : 819-823
28. Suga Y, Takamori K, Ogawa H (1993) Skin proteasomes (high-molecular-weight protease): purification, enzymologic properties, gross structure, and tissue distribution. J Invest Dermatol 101 : 346-351
29. Suzuki Y, Nomura J, Koyama J, Horii I (1994) The role of proteases in stratum corneum: involvement in stratum corneum desquamation. Arch Dermatol Res 286 : 249-253
30. Venning VA, Wojnarowska F, Cederholm-Williams S (1993) An immunohistochemical study of the distribution of plasminogen and plasminogen activators in bullous pemphigoid. Clin Exp Dermatol 18 : 119-123
31. Voros E, Robert C, Robert AM (1990) Age-related changes of the human skin surface microrelief. Gerontology 36 : 276-285
32. Wiedow O, Wiese F, Streit V, Kalm C, Christophers E (1992) Lesional elastase activity in psoriasis, contact dermatitis, and atopic dermatitis. J Invest Dermatol 99 : 306-309
33. Wormser U, Zbinden G (1985) Characterization of proteolytic systems in human and rat urine. Biochem Biophys Res Commun 127 : 191-197
34. Wormser U, Zbinden G (1986) Quantitative and qualitative changes of serum proteolytic activity in rats with liver damage induced by galactosamine. Arch Toxicol 59 : 111-114