Perflubron decreases inflammatory cytokine production by human alveolar macrophages

Critical Care Medicine

Volumn 25, Issue 12, 1997, Pages 2045-2047

  Thomassen, Mary Jane ^a   Buhrow, Lisa T ^a   Wiedemann, Herbert P ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

Author keywords

Adult respiratory distress syndrome; Anti inflammatory; Bronchoalveolar lavage; Cytokine; Endotoxin; Human alveolar macrophages; Interleukin 1; Interleukin 6; Partial liquid ventilation; Perflubron; Tumor necrosis factor

Indexed keywords

INTERLEUKIN 1; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; PERFLUOROOCTYL BROMIDE; TUMOR NECROSIS FACTOR ALPHA;

ADULT RESPIRATORY DISTRESS SYNDROME; ARTICLE; CELL CULTURE; CELL VIABILITY; CHEMICAL INJURY; CONTROLLED STUDY; ENDOTOXEMIA; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; HUMAN TISSUE; LUNG ALVEOLUS MACROPHAGE; LUNG GAS EXCHANGE; PRIORITY JOURNAL;

BRONCHOALVEOLAR LAVAGE; CELL SURVIVAL; CELLS, CULTURED; CONTRAST MEDIA; CYTOKINES; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLUOROCARBONS; HUMANS; MACROPHAGES, ALVEOLAR;

EID: 0031467614     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/00003246-199712000-00023     Document Type: Article

References (26)

1. Shaffer TH, Wolfson MR, Clark LC: Liquid ventilation. Pediatr Pulmonol 1992; 14:102-109
2. Hirschl RB, Tooley R, Parent AC, et al: Improvement of gas exchange, pulmonary function, and lung injury with partial liquid ventilation. Chest 1995; 108:500-508
3. Nesti FD, Fuhrman BP, Steinhorn DM, et al: Perfluorocarbon-associated gas exchange in gastric aspiration. Crit Care Med 1994; 22:1445-1452
4. Smith TM, Steinhorn DM, Thusu K, et al: A liquid perfluorochemical decreases the in vitro production of reactive oxygen species by alveolar macrophages. Crit Care Med 1995; 23:1533-1539
5. Hyers TM, Tricomi SM, Dettenmeier PA, et al: Tumor necrosis factor levels in serum and bronchoalveolar lavage fluid of patients with the adult respiratory distress syndrome. Am Rev Respir Dis 1991; 144:268-271
6. Jacobs RF, Tabor DR, Burks AW, et al: Elevated interleukin-1 release by human alveolar macrophages during the adult respiratory syndrome. Am Rev Respir Dis 1989; 140:1686-1692
7. Tracey KJ, Lowry SF, Cerami A: Cachectin/TNF-alpha in septic shock and septic adult respiratory distress syndrome. Am Rev Respir Dis 1988; 138:1377-1379
8. Marks JD, Marks CB, Luce JM, et al: Plasma tumor necrosis factor in patients with septic shock. Am Rev Respir Dis 1990; 141:94-97
9. Tracey KJ, Beutler B, Lowry SF, et al: Shock and tissue injury induced by recombinant human cachectin. Science 1986; 234:470-474
10. Borden EC, Chin P: Interleukin-6: A cytokine with potential diagnostic and therapeutic roles. J Lab Clin Med 1994; 123:824-829
11. Thomassen MJ, Meeker DP, Antal JM, et al: Synthetic surfactant (Exosurf) inhibits endotoxin-stimulated cytokine secretion by human alveolar macrophages. Am J Respir Cell Mol Biol 1992; 7:257-260
12. Thomassen MJ, Meeker DP, Antal JM, et al: Characterization of Exosurf (surfactant)-mediated suppression of stimulated human alveolar macrophage cytokine responses. Am J Respir Cell Mol Biol 1994; 10:399-104
13. Ghio AJ, Marshall BC, Diaz JL, et al: Tyloxapol inhibits NF-κB and cytokine release, scavenges HOCl, and reduces viscosity of cystic fibrosis sputum. Am J Respir Crit Care Med 1996; 154: 783-788
14. Baeuerle PA, Henkel T: Function and activation of NF-κB in the immune system. Annu Rev Immunol 1994; 12: 141-179
15. Thomassen MJ, Antal JM, Divis LT, et al: Regulation of human alveolar macrophage inflammatory cytokine by tyloxapol: A component of the synthetic surfactant Exosurf. Clin Immunol Immunopathol 1995; 77: 201-205
16. Raes M, Bosmans E, Delaive E, et al: Effects of antioxidants on IL-6 secretion induced by IL-1 in human cultured fibroblasts involvement of NF-κB. In: Oxidative Stress, Cell Activation and Viral Infection. Pasquier C, Olivier RY, Auclair C, et al (Eds). Basel, Birkhauser Verlag, 1994, pp 77-90
17. Thomassen MJ, Boxerbaum B, Demko CA, et al: Inhibitory effect of cystic fibrosis serum on Pseudomonas phagocytosis by rabbit and human alveolar macrophages. Pediatr Res 1979; 13:1085-1088
18. Mosmann T: Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays. J Immunol Methods 1983; 65:55-63
19. Simon RH, Ward PA: Adult respiratory distress syndrome. In: Inflammation: Basic Principles and Clinical Correlates. Gallin JI, Goldstein IM, Synderman R (Eds). New York, Raven Press, 1992, pp 999-1016
20. Rinaldo JE, Christman JW: Mechanisms and mediators of the adult respiratory distress syndrome. Clin Chest Med 1990; 11:621-632
21. Livingston DH, Mosenthal AC, Deitch EA: Sepsis and multiple organ dysfunction syndrome: A clinical-mechanistic overview. New Horiz 1995; 3: 257-266
22. Demling RH: Adult respiratory distress syndrome: Current concepts. New Horiz 1993; 1:388-401
23. Kelly J: Cytokines of the lung. Am Rev Respir Dis 1990; 141:765-788
24. Tütüncü A, Faithfull NS, Lachmann B: Intratracheal perfiuorocarbon administration combined with mechanical ventilation in experimental respiratory distress syndrome: Dose-dependent improvement of gas exchange. Crit Care Med 1993; 21:962-969
25. Antal JM, Divis LT, Erzurum SC, et al: Surfactant suppresses NF-κB activation in human monocytic cells. Am J Respir Cell Mol Biol 1996; 14:374-379
26. Bartlett R, Croce M, Hirschl R, et al: A phase II randomized, controlled trial of partial liquid ventilation (PLV) in adult patients with acute hypoxemic respiratory failure (AHRF). Abstr. Crit Care Med 1997; 25(Suppl):A35