Cyclophosphamide, doxorubicin, vincristine, prednisone dose intensification with granulocyte colony-stimulating factor markedly depletes stem cell reserve for autologous bone marrow transplantation

Blood

Volumn 90, Issue 12, 1997, Pages 4996-5001

  Freedman, Arnold ^a   Neuberg, Donna ^b   Mauch, Peter ^b   Gribben, John ^b   Soiffer, Robert ^b   Anderson, Kenneth ^b   Robertson, Michael ^b   Fisher, David C ^b   Schlossman, Robert ^b   Kroon, Mary ^b   Rhuda, Catherine ^b   Kuhlman, Caroline ^b   Ritz, Jerome ^b   Nadler, Lee ^b  

^a DANA FARBER CANCER INSTITUTE   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOPHOSPHAMIDE; DOXORUBICIN; GRANULOCYTE COLONY STIMULATING FACTOR; PREDNISONE; VINCRISTINE;

ADULT; ARTICLE; AUTOLOGOUS BONE MARROW TRANSPLANTATION; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG MEGADOSE; FEMALE; FOLLICULAR LYMPHOMA; HEMATOPOIETIC STEM CELL; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; LEUKOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; STEM CELL TRANSPLANTATION; SUBCUTANEOUS DRUG ADMINISTRATION; THROMBOCYTE COUNT; TREATMENT OUTCOME;

EID: 0031467613     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v90.12.4996.4996_4996_5001     Document Type: Article

References (28)

1. Frei E, Canellos G: Dose: A critical factor in cancer chemotherapy. Am J Med 68:585, 1980
2. Antman K, Griffin J, Elias A, Socinski M, Ryna L, Cannistra S, Oette D, Whitley M, Frei E, Schnipper L: Effect of recombinant granulocyte-macrophage colony stimulating factor on chemotherapy-induced myelosuppression. N Engl J Med 319: 593, 1988
3. Gabrilove J, Jakubowski A, Fain K, Grous J, Scher H, Sternberg C, Yagoda A, Clarkson B, Bonilla M, Oettgen H, Alton K, Boone T, Altrock B, Welte K, Souza L: Phase I study of granulocyte colony-stimulating factor in patients with transitional cell carcinoma of the urothelium. J Clin Invest 82:1454, 1988
4. Morstyn G, Campbell L, Souza L, Alton N, Keech J, Green M, Sheridan W, Metcalf D Fox, R: Effects of granulocyte colony stimulating factor on neutropenia induced by cytotoxic chemotherapy. Lancet 1:667, 1988
5. Moore M: Clinical implications of positive and negative hematopoietic stem cell regulators. Blood 78:1, 1991
6. Ayash L, Wheeler C, Fairclough D, Schwartz G, Reich E, Warren D, Schnipper L, Antman K, Frei E, Elias A: Prognostic factors for prolonged progression-free survival with high-dose chemotherapy with autologous stem-cell support for advanced breast cancer. J Clin Oncol 13:2043, 1995
7. Philip T, Guglielmi C, Hagenbeek A, Somers R, Van der Lelie H, Bron D, Sonneveld P, Gisselbrecht C, Cahn J, Harousseau J, Coiffier B, Biron P, Mandelli F, Chauvin F: Autologous bone marrow transplantation as compared with salvage chemotherapy in relapses of chemotherapy-sensitive non-Hodgkin's lymphoma. N Engl J Med 333:1540, 1995
8. Attal M, Harousseau J, Stoppa A, Sotto J, Fuzibet J, Rossi J, Cassassus P, Maisonneuve H, Facon T, Ifrah N, Payen C, Bataille R: A prospective randomized trial of autologous bone marrow transplantation and chemotherapy in multiple myeloma. N Engl J Med 335:91, 1996
9. National Cancer Institute sponsored study of classification of non-Hodgkin's lymphomas: Summary and description of a working formulation for clinical usage. The non-Hodgkin's lymphoma classification project. Cancer 49:2112, 1982
10. Freedman A, Gribben J, Neuberg D, Mauch P, Soiffer R, Anderson K, Pandite L, Robertson M, Kroon M, Ritz J, Nadler L: High dose therapy and autologous bone marrow transplantation in patients with follicular lymphoma during first remission. Blood 88:2780, 1996
11. Dana B, Dahlberg S, Nathwani B, Chase E, Coltman C, Miller T, Fisher R: Long-term follow-up of patients with low-grade malignant lymphomas treated with doxorubicin-based chemotherapy or chemoimmunotherapy. J Clin Oncol 11:644, 1993
12. Shipp M, Neuberg D, Janicek M, Canellos GP, Shulman LN: High-dose CHOP as initial therapy for patients with poor-prognosis aggressive non-hodgkin's lymphoma: A dose-finding pilot study. J Clin Oncol 13:2916, 1995
13. Freedman AS, Takvorian T, Anderson KC, Mauch P, Rabinowe SN, Blake K, Yeap B, Soiffer R, Coral F, Heflin L, Ritz J, Nadler LM: Autologous bone marrow transplantation in B-cell non-Hodgkin's lymphoma: Very low treatment-related mortality in 100 patients in sensitive relapse. J Clin Oncol 8:1, 1990
14. Freedman AS, Ritz J, Neuberg D, Anderson KC, Rabinowe SN, Mauch P, Takvorian T, Soiffer R, Blake K, Yeap B, Coral F, Helfin L, Nadler LM: Autologous bone marrow transplantation in 69 patients with a history of low grade B cell non-Hodgkin's lymphoma. Blood 77:2524, 1991
15. Jones R, Celano P, Sharkis S, Sensenbrenner L: Two phases of engraftment established by serial bone marrow transplantation in mice. Blood 73:397, 1989
16. Sutherland H, Eaves C, Eaves A, Dragowska W, Lansdorp P: Characterization and partial purification of human marrow cells capable of initiating long-term hematopoiesis in vitro. Blood 74:1563, 1989
17. Jones R, Wagner J, Celano P, Zicha M, Sharkis S: Separation of pluripotent hematopoietic stem cells from spleen colony-forming units. Nature 347:397, 1990
18. Smith C, Gasparetto C, Collins N, Gillio A, Muench M, O'Reilly R, Moore M: Purification and partial characterization of a human pre-CFU precursor population. Blood 77:2122, 1991
19. Siminovitch L, Till J, McCulloch E: Decline in colony-forming ability of marrow cells subjected to serial transplantation into irradiated mice. J Cell Comp Physiol 64:23, 1964
20. Mauch P, Rosenblatt M, Hellman S: Permanent loss in stem cell self renewal capacity following stress to the marrow. Blood 72:1193, 1988
21. Mauch P, Hellman S: Loss of hematopoietic stem cell selfrenewal after bone marrow transplantation. Blood 74:872, 1989
22. Neben S, Hellman S, Montgomery M, Ferrara J, Mauch P: Hematopoietic stem cell deficit of transplanted bone marrow previously exposed to cytotoxic agents. Exp Hematol 21:156, 1993
23. Mauch P, Constine L, Greenberger J, Knospe W, Sullivan J, Liesveld JL, Deeg HJ: Hematopoietic stem cell compartment: Acute and late effects of radiation therapy and chemotherapy. Int J Radiat Oncol Biol Phys 31:1319, 1995
24. Hornung R, Longo DL: Hematopoietic stem cell depletion by restorative growth factor regimens during repeated high-dose cyclophosphamide therapy. Blood 80:77, 1992
25. Molineux G, Migdalska A, Haley J, Evans GS, Dexter TM: Total marrow failure induced by pegylated stem-cell factor administered before 5-fluorouracil. Blood 83:3491, 1994
26. Moore M: Does stem cell exhaustion result from combining hematopoietic growth factors with chemotherapy? If so, how do we prevent it? Blood 80:3, 1992
27. Gianni A, Bregni M, Siena S, Brambilla C, Di Nicola M, Lombardi F, Gandoloa L, Tarella C, Pileri A, Ravagnani F, Valagussa P, Bonadonna G: High-dose chemotherapy and autologous bone marrow transplantation compared with MACOP-B in aggressive B-cell lymphoma. N Engl J Med 336:1290, 1997
28. Dreger P, Kloss M, Petersen B, Haferlach T, Lofler H, Loeffler M, Schmitz N: Autologous progenitor cell transplantation: Prior exposure to stem cell toxic drugs determines yield and engraftment of peripheral blood progenitor cell but not of bone marrow grafts. Blood 86:3970, 1995