Recovery of pancreatic β-cell function in hemochromatosis: Combined treatment with recombinant human erythropoietin and phlebotomy

American Journal of the Medical Sciences

Volumn 314, Issue 6, 1997, Pages 401-402

  Inoue, Yasushi ^a   Nakanishi, Koji ^a   Hiraga, Takaki ^a   Okubo, Minoru ^a   Murase, Toshio ^a   Kosaka, Kinori ^a   Miyakoshi, Shigesaburo ^a   Mutoh, Yoshitomo ^a   Kobayashi, Tetsuro ^a  

^a TORANOMON HOSPITAL   (Japan)

Author keywords

Diabetes mellitus; Hemochromatosis; Pancreatic cell function; Phlebotomy; Recombinant human erythropoietin

Indexed keywords

FERRITIN; HEMOGLOBIN A1C; IRON; RECOMBINANT ERYTHROPOIETIN;

AGED; ARTICLE; CASE REPORT; CLINICAL FEATURE; COMORBIDITY; DIABETES MELLITUS; DRUG EFFECT; DRUG EFFICACY; FERRITIN BLOOD LEVEL; GLUCOSE BLOOD LEVEL; HEMOCHROMATOSIS; HUMAN; IRON DEFICIENCY ANEMIA; MALE; PHLEBOTOMY; SUBCUTANEOUS DRUG ADMINISTRATION; TREATMENT PLANNING;

EID: 0031467532     PISSN: 00029629     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000441-199712000-00008     Document Type: Article

References (7)

1. Nichols GM, Bacon BR. Hereditary hemochromatosis: Pathogenesis and clinical features of a common disease. Am J Gastroenterol. 1989; 84:851-62.
2. Rahier J, Loozen S, Goebbels RM, Abrahem M. The haemochromatotic human pancreas: A quantitative immunohistochemical and ultrastructural study. Diabetologia. 1987; 30:5-12.
3. Nakanishi K, Kobayashi T, Miyashita H, Ohkubo M, Sugimoto T, Murase T, et al. Relationships among islet cell antibodies, residual β-cell function, and metabolic control in patients with insulin-dependent diabetes mellitus of long duration: Use of a sensitive C-peptide radioimmunoassay. Metabolism. 1990; 39:925-30.
4. McCarthy JT, Johnson WJ, Nixon DE, Jenson BM, Moyer TP. Transfusional iron overload in patients undergoing dialysis: Treatment with erythropoietin and phlebotomy. J Lab Ciln Med. 1989; 114:193-9.
5. Nomura S, Osawa G, Karai M. Treatment of a patient with end-stage renal disease, severe iron overload and ascites by weekly phlebotomy combined with recombinant human erythropoietin. Nephron. 1990; 55:210-13.
6. Hotta T, Inoue C, Tsushita K, Miura Y, Saito H. Successful treatment of hemosiderosis with regular phlebotomy and recombinant human erythropoietin. Acta Haematol. 1991; 86:214-6.
7. Onoyama K, Nakamura S, Yamamoto M, Kawadoko T, Nanishi F, Komada T, et al. Correction of serious iron overload in a chronic hemodialysis patient by recombinant human erythropoietin and removal of red blood cells : Confirmation by follow-up liver biopsy. Nephron. 1990; 56:325-8.