The carboxyl-terminal zinc-binding domain of the human papillomavirus E7 protein can be functionally replaced by the homologous sequences of the E6 protein

Virus Research

Volumn 52, Issue 1, 1997, Pages 109-118

  Mavromatis, Kreton O ^a   Jones, D Leanne ^b   Mukherjee, Rupa ^b   Yee, Carole ^a   Grace, Miranda ^b   Münger, Karl ^b  

^a NATIONAL CANCER INSTITUTE   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

E2F; E6; E7; Human papillomavirus; Retinoblastoma tumor suppressor protein

Indexed keywords

CHIMERIC PROTEIN; RETINOBLASTOMA PROTEIN; VIRUS PROTEIN;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; RAT; SEQUENCE HOMOLOGY; TRANSACTIVATION; VIRUS CELL TRANSFORMATION; WART VIRUS;

AMINO ACID SEQUENCE; ANIMALS; CELL LINE; HUMANS; KIDNEY; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; ONCOGENE PROTEINS, VIRAL; PAPILLOMAVIRIDAE; PROTEIN STRUCTURE, TERTIARY; RATS; REPRESSOR PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; ZINC;

EID: 0031466179     PISSN: 01681702     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-1702(97)00090-7     Document Type: Article

References (36)

1. Antinore, M.J., Birrer, M.J., Patel, D., Nader, L., McCance, D.J., 1996. The human papillomavirus type 16 E7 gene product interacts with and trans-activates the AP1 family of transcription factors. EMBO J. 15, 1950-1960.
2. Bosch, F.X., Manos, M.M., Munoz, N., Sherman, M., Jansen, A.M., Peto, J., Schiffman, M.H., Moreno, V., Kurman, R., Shah, K.V., Alihonou, E., Bayo, S., Mokhtar, H.C., Chicareon, S., Daudt, A., Delosrios, E., Ghadirian, P., Kitinya, J.N., Koulibaly, M., Ngelangel, C., Tintore, L.M.P., Riosdalenz, J.L., Sarjadi-Schneider, A., Tafur, L., Teyssie, A.R., Rolon, P.A., Torroella, M., Tapia, A.V., Wabinga, H.R., Zatonski, W., Sylla, B., Vizcaino, P., Magnin, D., Kaldor, J., Greer, C., Wheeler, C., 1995. Prevalence of human papillomavirus in cervical cancer: a worldwide perspective.. J. Nat. Cancer Inst. 87, 796-802.
3. Boyer, S.N., Wazer, D.E., Band, V., 1996. E7 protein of human papilloma virus-16 induces degradation of retinoblastoma protein through the ubiquitin-proteasome pathway. Cancer Res. 56, 4620-4624.
4. Chellappan, S., Kraus, V.B., Kroger, B., Münger, K., Howley, P.M., Phelps, W.C., Nevins, J.R., 1992. Adenovirus E1A, simian virus 40 tumor antigen, and human papillomavirus E7 protein share the capacity to disrupt the interaction between the transcription factor E2F and the retinoblastoma gene product. Proc. Natl. Acad. Sci. USA 89, 4549-4553.
5. Chen, J.J., Reid, C.E., Band, V., Androphy, E.J., 1995. Interaction of papillomavirus E6 oncoproteins with a putative calcium-binding protein. Science 269, 529-531.
6. Clemens, K.E., Brent, R., Gyuris, J., Münger, K., 1995. Dimerization of the human papillomavirus E7 oncoprotein in vivo. Virology 214, 289-293.
7. Cole, S.T., Danos, O., 1987. Nucleotide sequence and comparative analysis of the human papillomavirus type 18 genome: phylogeny of papillomaviruses and repeated structures of the E6 and E7 gene products. J. Mol. Biol. 193, 599-608.
8. Crook, T., Tidy, J.A., Vousden, K.H., 1991. Degradation of p53 can be targeted by HPV E6 sequences distinct from those required for p53 binding and transactivation. Cell 67, 547-556.
9. Huang, P.S., Patrick, D.R., Edwards, G., Goodhart, P.J., Huber, H.E., Miles, L., Garsky, V.M., Oliff, A., Heimbrook, D.C., 1993. Protein domains governing interactions between E2F, the retinoblastoma gene product, and human papillomavirus type 16 E7 protein. Mol. Cell. Biol. 13, 953-960.
10. Huibregtse, J.M., Scheffner, M., Howley, P.M., 1991. A cellular protein mediates association of p53 with the E6 oncoprotein of human papillomavirus types 16 or 18. EMBO J. 10, 4129-4135.
11. Jansen-Dürr, P., 1996. How viral oncogenes make the cell cycle. Trends Genet. 12, 270-275.
12. Jewers, R.J., Hildebrandt, P., Ludlow, J.W., Kell, B., McCance, D.J., 1992. Regions of human papillomavirus type
13. Jones, D.L., Münger, K., 1997. Analysis of the p53-mediated G1 growth arrest pathway in cells expressing the human papillomavirus type 16 E7 oncoprotein. J. Virol. 71, 2905-2912.
14. Jones, R.E., Wegrzyn, R.J., Patrick, D.R., Balishin, N.L., Vuocolo, G.A., Riemen, M.W., Defeo-Jones, D., Garski, V.M., Heimbrook, D.C., Oliff, A., 1990. Identification of HPV-16 E7 peptides that are potent antagonists of E7 binding to the retinoblastoma suppressor protein. J. Biol. Chem. 265, 12782-12785.
15. Kaye, F.J., Kratzke, R.A., Gerster, J.L., Horowitz, J.M., 1990. A single amino acid substitution results in a retinoblastoma protein defective in phosphorylation and oncoprotein binding. Proc. Natl. Acad. Sci. USA 87, 6922-6926.
16. Keen, N., Elston, R., Crawford, L., 1994. Interaction of the E6 protein of human papillomavirus with cellular proteins. Oncogene 9, 1493-1499.
17. Lam, E.W.F., Morris, J.D.H., Davies, R., Crook, T., Watson, R.J., Vousden, K.H., 1994. HPV16 E7 oncoprotein deregulates b-myb expression - correlation with targeting of p107/E2F complexes. EMBO J. 13, 871-878.
18. Mcintyre, M.C., Frattini, M.G., Grossman, S.R., Laimins, L.A., 1993. Human papillomavirus type 18 E7 protein requires intact Cys-X-X-Cys motifs for zinc binding, dimerization, and transformation but not for Rb binding. J. Virol. 67, 3142-3150.
19. Münger, K., Phelps, W.C., 1993. The human papillomavirus-E7 protein as a transforming and trans-activating factor. Biochim. Biophys. Acta 1155, 111-123.
20. Münger, K., Scheffner, M., Huibregtse, J.M., Howley, P.M., 1992. Interactions of HPV E6 and E7 with tumour suppressor gene products. Cancer Surv. 12, 197-217.
21. Nevins, J.R., 1992. E2F: A link between the Rb tumor suppressor protein and viral oncoproteins. Science 258, 424-429.
22. Pagano, M., Dürst, M., Joswig, S., Draetta, G., Jansen-Dürr, P., 1992. Binding of the human E2F transcription factor to the retinoblastoma protein but not to cyclin A is abolished in HPV-16-immortalized cells. Oncogene 7, 1681-1686.
23. Patrick, D.R., Oliff, A., Heimbrook, D.C., 1994. Identification of a novel retinoblastoma gene product binding site on human papillomavirus type 16 E7 protein. J. Biol. Chem. 269, 6842-6850.
24. Phelps, W.C., Bagchi, S., Barnes, J.A., Raychaudhuri, P., Kraus, V., Münger, K., Howley, P.M., Nevins, J.R., 1991. Analysis of trans activation by human papillomavirus type 16 E7 and adenovirus 12S E1A suggests a common mechanism. J. Virol. 65, 6922-6930.
25. Phelps, W.C., Münger, K., Yee, C.L., Barnes, J.A., Howley, P.M., 1992. Structure-function analysis of the human papillomavirus E7 oncoprotein. J. Virol. 66, 2418-2427.
26. Phelps, W.C., Yee, C.L., Münger, K., Howley, P.M., 1988. The human papillomavirus type 16 E7 gene encodes transactivation and transformation functions similar to adenovirus E1a. Cell 53, 539-547.
27. Sedman, S.A., Barbosa, M.S., Vass, W.C., Hubbert, N.L., Haas, J.A., Lowy, D.R., Schiller, J.T., 1991. The full-length E6 protein of human papillomavirus type 16 has transforming and trans-activating activities and cooperates with E7 to immortalize keratinocytes in culture. J. Virol. 65, 4860-4866.
28. Scheffner, M., Huibregtse, J.M., Vierstra, R.D., Howley, P.M., 1993. The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53. Cell 75, 495-505.
29. Scheffner, M., Münger, K., Huibregtse, J.M., Howley, P.M., 1992. Targeted degradation of the retinoblastoma protein by human papillomavirus E7-E6 fusion proteins. EMBO J. 11, 2425-2431.
30. Scheffner, M., Nuber, U., Huibregtse, J.M., 1995. Protein ubiquitination involving an E1-E2-E3 enzyme ubiquitin thioester cascade. Nature 373, 81-83.
31. Scheffner, M., Werness, B.A., Huibregtse, J.M., Levine, A.J., Howley, P.M., 1990. The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53. Cell 63, 1129-1136.
32. Stirdivant, S.M., Huber, H.E., Patrick, D.R., Defeo-Jones, D., McAvoy, E.M., Garsky, V.M., Oliff, A., Heimbrook, D.C., 1992. Human papillomavirus type 16 E7 protein inhibits DNA binding by the retinoblastoma gene product. Mol. Cell. Biol. 12, 19051914.
33. Werness, B.A., Levine, A.J., Howley, P.M., 1990. Association of human papillomavirus types 16 and 18 E6 proteins with p53. Science 248, 76-79.
34. Wu, E.W., Clemens, K.E., Heck, D.V., Münger, K., 1993. The human papillomavirus E7 oncoprotein and the cellular transcription factor E2F bind to separate sites on the retinoblastoma tumor suppressor protein. J. Virol. 67, 2402-2407.
35. zur Hausen, H., 1996. Papillomavirus infections - a major cause of human cancers. Biochim. Biophys. Acta 1288, F55-F78.
36. Zwerschke, W., Joswig, S., Jansen Dürr, P., 1996. Identification of domains required for transcriptional activation and protein dimerization in the human papillomavirus type-16 E7 protein. Oncogene 12, 213-220.