A 23-year-old man with a mediatinal embryonal carcinoma and hematologic abnormalities

New England Journal of Medicine

Volumn 337, Issue 26, 1997, Pages 1904-1912

  Garnick, M B ^a   Ferry, J A ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

ACUTE MYELOBLASTIC LEUKEMIA; ADULT; ARTICLE; CASE REPORT; CLINICAL FEATURE; COMPUTER ASSISTED TOMOGRAPHY; COUGHING; GERM CELL TUMOR; HUMAN; LUNG ANGIOGRAPHY; LUNG ARTERY PRESSURE; MALE; MEDIASTINUM MASS; PRIORITY JOURNAL; SUPERIOR CAVA VEIN SYNDROME; THORAX SCINTISCANNING;

EID: 0031465003     PISSN: 00284793     EISSN: None     Source Type: Journal    
DOI: 10.1056/NEJM199712253372608     Document Type: Article

References (36)

1. Lederman GS, Garnick MB. Pulmonary emboli as a complication of germ cell cancer treatment. J Urol 1987;137:1236-7.
2. Case Records of the Massachusetts General Hospital (Case 34-1983). N Engl J Med 1983;309:477-87.
3. Hurley LJ, Burke CR, Shetty SK, Sakr OE, Previte SR, Libertino JA. Elevated alpha-fetoprotein secondary to Hodgkin's lymphoma. Urology 1996;48:936-8.
4. Patriarca C, Orazi A, Massimino M, Luksch R. A cystic partially differentiated nephroblastoma producing alpha-fetoprotein. Am J Pediatr Hematol Oncol 1992;14:352-5.
5. Friedman EL, Garnick MB. Extragonadal and central nervous system germ cell tumors: a review of diagnostic and therapeutic strategies. In: Muggia FM, ed. Concepts, clinical developments, and therapeutic advances in cancer chemotherapy. Vol. 36 of Cancer treatment and research. Norwell, Mass.: Kluwer Academic, 1987:103-28.
6. Witschi E. Migration of the germ cells of human embryos from the yolk sac to the primitive gonadal folds. Contrib Embryol 1948;32:69-80.
7. Schlumberger HG. Teratoma of the anterior mediastinum in the group of military age. Arch Pathol 1946;41:398-444.
8. Pugsley WS, Carleton RL. Germinal nature of teratoid tumors of the thymus. Arch Pathol 1953;56:341-7.
9. Prym P. Spontanheilung eines bösartigen, wahrscheinlich chorionepitheliomatösen Gewächses im Hoden. Virchows Arch 1927;265:239-58.
10. Schimke RN, Madigan CM, Silver BJ, Fabian CJ, Stephens RL. Choriocarcinoma, thyroroxicosis, and the Klinefelter syndrome. Cancer Genet Cytogenet 1983;9:1-7.
11. Mann BD, Sparkes RS, Kern DH, Morton DL. Chromosomal abnormalities of a mediastinal embryonal cell carcinoma in a patient with 47,XXY Klinefelter syndrome: evidence for the premeiotic origin of a germ cell tumor. Cancer Genet Cytogenet 1983;8:191-6.
12. McNeil MM, Leong AS, Sage RE. Primary mediastinal embryonal carcinoma in association with Klinefelter's syndrome. Cancer 1981;47:343-5.
13. Nichols CR, Heerema NA, Palmer C, Loehrer PJ Sr, Williams SD, Einhorn LH. Klinefelter's syndrome associated with mediastinal germ cell neoplasms. J Clin Oncol 1987;5:1290-4.
14. Garnick MB, Canellos GP, Richie JP. Treatment and surgical staging of testicular and primary extragonadal germ cell cancer. JAMA 1983;250: 1733-41.
15. Einhorn LH, Donohue J. Cis-diamminedichloroplatinum, vinblastine, and bleomycin combination chemotherapy in disseminated testicular cancer. Ann Intern Med 1977;87:293-8.
16. Rees GJ, Slade RR, Hopes P. Reduced platelet survival following chemotherapy with vinblastine, bleomycin and cis-platinum for testicular teratoma. Eur J Cancer Clin Oncol 1982;18:1125-9.
17. Nichols CR, Breeden ES, Loehrer PJ, Williams SD, Einhorn LH. Secondary leukemia associated with a conventional dose of etoposide: review of serial germ cell tumor protocols. J Natl Cancer Inst 1993;85:36-40.
18. Redman JR, Vugrin D, Arlin ZA, et al. Leukemia following treatment of germ cell tumors in men. J Clin Oncol 1984;2:1080-7.
19. Canellos GP. Therapy-related leukemia: a necessary complication of successful systemic chemotherapy? J Clin Oncol 1984;2:1077-9.
20. Canale D, Feldman R, Rosen M, Harvard MB. Autoimmune hemolytic anemia associated with seminoma. Urology 1975;5:411-4.
21. Lundberg WB, Mitchell MS. Transient warm autoimmune hemolytic anemia and cryoglobulinemia associated with seminoma. Yale J Biol Med 1977;50:419-27.
22. Kim HD, Boggs DR. A syndrome resembling idiopathic thrombocytopenic purpura in 10 patients with diverse forms of cancer. Am J Med 1979;67:371-7.
23. Garnick MB, Griffin JD. Idiopathic thrombocytopenia in association with extragonadal germ cell cancer. Ann Intern Med 1983;98:926-7.
24. Helman LJ, Ozols RF, Longo DL. Thrombocytopenia and extragonadal germ-cell neoplasm. Ann Intern Med 1984;101:280.
25. DeMent SH, Eggleston JC, Spivak JL. Association between mediastinal germ cell tumors and hematologic malignancies: report of two cases and review of the literature. Am J Surg Pathol 1985;9:23-30.
26. Nichols CR, Hoffman R, Einhorn LH, Williams SD, Wheeler LA, Garnick MB. Hematologic malignancies associated with primary mediastinal germ-cell tumors. Ann Intern Med 1985;102:603-9.
27. Nichols CR, Roth BJ, Heerema N, Griep J, Tricot G. Hematologic neoplasia associated with primary mediastinal germ-cell tumors. N Engl J Med 1990;322:1425-9.
28. Ladanyi M, Samaniego F, Reuter VE, et al. Cytogenetic and immunohistochemical evidence for the germ cell origin of a subset of acute leukemias associated with mediastinal germ cell tumors. J Natl Cancer Inst 1990;82:221-7.
29. Woodruff K, Wang N, May W, Adrone E, Denny C, Feig SA. The clonal nature of mediastinal germ cell tumors and acute myclogenous leukemia: a case report and review of the literature. Cancer Genet Cytogenet 1995;79:25-31.
30. Orazi A, Neiman RS, Ulbright TM, Heerema NA, John K, Nichols CR. Hematopoietic precursor cells within the yolk sac tumor component are the source of secondary hematopoietic malignancies in patients with mediastinal germ cell tumors. Cancer 1993;71:3873-81.
31. Ulbright TM, Loehrer PJ, Roth LM, Einhorn LH, Williams SD, Clark SA. The development of non-germ cell malignancies within germ cell tumors: a clinicopathologic study of 11 cases. Cancer 1984;54:1824-33.
32. Davey DD, Ulbright TM, Loehrer PJ, Einhorn LH, Donohue JP, Williams SD. The significance of atypia within teratomatous metastases after chemotherapy for malignant germ cell tumors. Cancer 1987;59:533-9.
33. Logothetis CJ, Samuels ML, Trindade A, Johnson DE. The growing teratoma syndrome. Cancer 1982;50:1629-35.
34. Ahlgren AD, Simrell CR, Triche TJ, Ozols R, Barsky SH. Sarcoma arising in a residual testicular teratoma after cytoreductive chemotherapy. Cancer 1984;54:2015-8.
35. Ahmed T, Bosl GJ, Hajdu SI. Teratoma with malignant transformation in germ cell tumors in men. Cancer 1985;56:860-3.
36. Oosterhuis JW, de Jong B, Cornelisse CJ, et al. Karyotyping and DNA flow cytometry of mature residual teratoma after intensive chemotherapy of disseminated nonseminomatous germ cell tumor of the testis: a report of two cases. Cancer Genet Cytogenet 1986;22:149-57