Co-expression of immunogenic determinants by the same cellular immunogen is required for the optimum immunotherapeutic benefit in mice with melanoma

Cancer Immunology Immunotherapy

Volumn 45, Issue 5, 1997, Pages 217-224

  Xu, Weisong ^a   De Zoeten, Edwin ^a   Carr Brendel, Victoria ^a   Cohen, Edward P ^a  

^a Dept of Microbiology and Immunology ^*  (United States)

Author keywords

Hybrid cells; Immunotherapy; Melanoma; Semi allogeneic

Indexed keywords

ANTIGEN; BIOLOGICAL RESPONSE MODIFIER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; IMMUNOGENICITY; IMMUNOTHERAPY; KILLER CELL; MELANOMA; MOUSE; NONHUMAN; PRIORITY JOURNAL; RISK BENEFIT ANALYSIS;

ANIMALS; CANCER VACCINES; CD8-POSITIVE T-LYMPHOCYTES; EPITOPES, T-LYMPHOCYTE; FIBROBLASTS; HISTOCOMPATIBILITY ANTIGENS CLASS I; HYBRID CELLS; MELANOMA, EXPERIMENTAL; MICE; MICE, INBRED C3H; MICE, INBRED C57BL; NEOPLASM PROTEINS; T-LYMPHOCYTES, CYTOTOXIC; VACCINATION; VACCINES, SYNTHETIC;

EID: 0031463983     PISSN: 03407004     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002620050436     Document Type: Article

References (22)

1. Bakker ABH, Schreurs JWJ, Boer AJ de, Kawakami Y, Rosenberg SA, Adema GJ, Figdor CG (1994) Melanocyte lineage-specific antigen gp100 is recognized by melanoma derived tumor infiltrating lymphocytes. J Exp Med 179:1005
2. Boon T (1992) Toward a genetic analysis of tumor rejection antigens. Adv Cancer Res 58:177
3. Boon T (1993) Tumor antigens recognized by cytolytic T lymphocytes: present perspectives for specific immunotherapy. Int J Cancer 54:177
4. Boon T, De Plaen E, Lurquin C, Van den Eynde B, Bruggen P van der, Traversari C, Amar-Costesec A (1992) Identification of tumor rejection antigens recognized by T lymphocytes. Cancer Surv 13:23
5. Brichard V, Van Pel A, Wolfel T, Wolfel C, De Plaen E, Lethe B, Coule P, Boon T (1993) The tyrosinase gene codes for an antigen recognized by autologous cytolytic lymphocytes on HLA-A2 melanomas. J Exp Med 178:489
6. Bruggen P van der, Traversari C, Chomez P, Lurquin C, De Plaen E, Van den Eynde B, Knuth A, Boon T (1991) A gene encoding an antigen recognized by cytolytic T lymphocytes on a human melanoma. Science 254:1643
7. + T lymphocytes in the primary and memory response to nonimmunogenic murine mammary adenocarcinoma made immunogenic by the 1L-2 gene. J Immunol 149:3627
8. Cox AL, Skipper J, Chen Y, Henderson RA, Darrow TL, Shabanowitz J, Engelhard VH, Hunt DF, Slingluff CL Jr (1994) Identification of a peptide recognized by five melanoma-specific human cytotoxic T cell lines. Science 264:716
9. + T-cells: ICAM-1 or B7-1 can costimulate naive CD4 T cell activation hut both are required for optimum response. J Immunol 155:45
10. Dutz JP, Tsomides TJ, Kageyama, S, Rasmussen MH, Eisen HN (1994) A cytotoxic T lymphocyte clone can recognize the same naturally occurring self peptide in association with a self and nonself class I MHC protein. Mol Immunol 31:967
11. Grandea AG III, Bevan MJ (1992) Single residue changes in class I major histocompatability complex molecules stimulate responses to self peptides. Proc Natl Acad Sci USA 89:2794
12. d). Cancer Res 47:3136
13. Kawakami Y, Eliyahu S, Delgado CH, et al (1994) Cloning of the gene encoding for a shared human melanoma antigen recognized by autologous T cells infiltrating tumor. Proc Natl Acad Sci USA 91:3515
14. Kim TS, Russell SJ, Collins MKL, Cohen EP (1992) Immunity to B16 melanoma in mice immunized with IL-2-secreting allogeneic mouse fibroblasts expressing melanoma-associated antigens. Int J Cancer 51:283
15. Kim TS, Russell SJ, Collins MKL, Cohen EP (1993) Immunization with interleukin-2-secreting allogeneic mouse fibroblasts expressing melanoma-associated antigens prolongs the survival of tumor-bearing mice with melanoma. Int J Cancer 55:865
16. Kim TS, Cohen EP (1994) MHC antigen expression by melanomas recovered from mice treated with allogeneic mouse fibroblasts genetically modified for interleukin-2 secretion and the expression of melanoma-associated antigens. Cancer Immunol Immunother 38:185
17. Kovacsovics-Bankowski M, Rock KL (1995) A phagosome to cytosol pathway for exogenous antigens presented on MHC class I molecules. Science 267:243
18. Kundig TM, Bachmann MF, DiPaolo C, Simard JJL, Battegay M, Lother H, Gessner A, Kuhlcke K, Ohashi PS, Hengartner H, Zukernagel RM (1995) Fibroblasts as efficient antigen-presenting cells in lymphoid organs. Science 268:1343
19. Mandelboim O, Vadai E, Feldman M, Eisenbach L (1995) Expression of two H-2K genes, syngeneic and allogeneic, as a strategy for potentiating immune recognition of tumor cells. Gene Ther 2:757
20. Restifo NP, Esquivel F, Asher AL, Stotter H, Barth RJ, Bennink JR, Mulé JJ, Yewdell JW, Rosenberg SA (1991) Detective presentation of endogenous antigens by a murine sarcoma: implications lor the failure of an anti tumor immune response. J Immunol 147:1453
21. Rock KL, Gramm C, Rothstein L, Clark K, Stein R, Dick L, Hwang D, Goldberg AL (1994) Inhibitors of the proteosome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules. Cell 78:761
22. Slingluff CL Jr, Cox AL, Henderson RA, Hunt DF, Engelhard VH (1993) Recognition of human melanoma cells by HLA-A2.1-restricted cytotoxic T lymphocytes is mediated by at least six shared peptide epitopes. J Immunol 150:2955