Hydroxyakalone, a novel xanthine oxidase inhibitor produced by a marine bacterium, Agrobacterium aurantiacum

Journal of Antibiotics

Volumn 50, Issue 11, 1997, Pages 916-918

  Izumida, Hitoshi ^b   Adachi, Kyoko ^a   Mihara, Akira ^c   Yasuzawa, Tohru ^c   Sano, Hiroshi ^a  

^a MARINE BIOTECHNOLOGY INSTITUTE   (Japan)

^b KANSAI PAINT CO LTD   (Japan)

^c KYOWA HAKKO KOGYO CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AKALONE; ALLOPURINOL; ANTIGOUT AGENT; HYDROXYAKALONE; UNCLASSIFIED DRUG; XANTHINE OXIDASE; XANTHINE OXIDASE INHIBITOR;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; DRUG ISOLATION; DRUG POTENCY; DRUG STRUCTURE; ENZYME INHIBITION; FAST ATOM BOMBARDMENT MASS SPECTROMETRY; FERMENTATION; METHYLATION; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; RHIZOBIUM; ULTRAVIOLET SPECTROSCOPY;

EID: 0031463476     PISSN: 00218820     EISSN: None     Source Type: Journal    
DOI: 10.7164/antibiotics.50.916     Document Type: Article

References (5)

1. NORO, T.; K. NORO, T. MIYASE, M. KUROYANAGI, K. UMEHARA, A. UENO & S. FUKUSHIMA: Inhibition of xanthine oxidase by anthraquinones. Chem. Pharm. Bull. 35: 4314-4316, 1987
2. NORO, T.; Y. ODA, T. MIYASE, A. UENO & S. FUKUSHIMA: Inhibitors of xanthine oxidase from the flowers and buds of Dephne genkwa. Chem. Pharm. Bull. 31: 3984-3987. 1983
3. NORO, T.; A. UENO, M. MIZUTANI, T. HASHIMOTO, T. MIYASE, M. KUROYANAGI & S. FUKUSHIMA: Inhibitors of xanthine oxidase from Athyrium mesosorum. Chem. Pharm. Bull. 32: 4455-4459, 1984
4. NAKANISHI, T.; M. NISHI, A. INADA, H. OBATA, N. TANABE, S. ABE & M. WAKASHIRO: Two new potent inhibitors of xanthine oxidase from leaves of perilla frutescens britton var. acuta kudo. Chem. Pharm. Bull. 38: 1772-1774, 1990
5. IZUMIDA, H.; K. ADACHI, M. NISHIJIMA, M. ENDO & W. MIKI: Akalone: A novel xanthine oxidase inhibitor produced by the marine bacterium, Agrobacterium aurantiacum sp. nov. J. Mar. Biotechnol. 2: 115-118. 1995