Determination of a isoflavone derivative, ipriflavone, and its metabolites, M1 and M5, in rat plasma, urine, and tissue homogenate by high- performance liquid chromatography

Research Communications in Molecular Pathology and Pharmacology

Volumn 98, Issue 3, 1997, Pages 313-324

  Kim, So H ^a   Lee, Jung Sik ^b   Lee, Myung G ^a  

^a Seoul National University   (South Korea)

^b Samchundang Pharm Co Ltd   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

7 (1 CARBOXYETHOXY) 3 PHENYL 4H 1 BENZOPYRAN 4 ONE; 7 HYDROXY 3 PHENYL 4H 1 BENZOPYRAN 4 ONE; DIAZEPAM; DRUG METABOLITE; IPRIFLAVONE; ISOFLAVONE DERIVATIVE; TESTOSTERONE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG STRUCTURE; DRUG TISSUE LEVEL; DRUG URINE LEVEL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; NONHUMAN; PRIORITY JOURNAL; RAT; STANDARD; TISSUE HOMOGENATE;

ANALGESICS; ANIMALS; BUFFERS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DIAZEPAM; ISOFLAVONES; RATS; RATS, SPRAGUE-DAWLEY; REFERENCE STANDARDS; TESTOSTERONE; TISSUE DISTRIBUTION;

EID: 0031463108     PISSN: 10780297     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (6)

1. Kaplan, A., Szabo, L. L. and Opheim, K. E. (1988): Clinical Chemistry, Lea & Febiger, Philadelphia, 3rd Ed. 379-383.
2. Reginster, J.-Y. L. (1993): Ipriflavone: Pharmacological properties and usefulness in postmenopausal osteoporosis. Bone Miner., 23, 223-232.
3. Rondelli, I., Acerbi, D. and Ventura, P. (1991): Steady-state pharmacokinetics of ipriflavone and its metabolites in patients with renal failure. Int. J. Pharm. Res., 11, 183-192.
4. Shino, M. (1985): Pharmacokinetic study of ipriflavone (TC80) by oral administration in healthy male volunteers. Jap. Pharmacol. Ther., 13, 7223-7233.
5. Sustacha, K., Chacón, M., Lucero, M. L. and Orjales, A. (1996): Determination of ipriflavone and its synthentic impurities by high-performance liquid chromatography using diode-array detection. J. Chromatogr. A., 719, 245-250.
6. Yoshida, K., Tsukamoto, T., Torii, M., Doi, T., Naeshiro, I., Uemura, I. and Tanayama, S. (1985): Metabolism of ipriflavone (TC-80) in rats. Radioisotopes, 34, 612-617.