Epstein-Barr virus BHRF1 prohibits the cells of nasopharyngeal carcinoma from apoptosis

Journal of Laryngology and Otology

Volumn 111, Issue 12, 1997, Pages 1147-1150

  Huang, H ^a   Zhou, J H ^a,d   Zhou, S M ^a   Hu, J H ^a,d   Pan, X H ^b   Kong, X T ^c   Yu, L ^c   Sun, X Y ^e   Wu, W ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b SECOND MILITARY MEDICAL UNIVERSITY   (China)

^c SECOND MILITARY MEDICAL UNIVERSITY   (China)

^d FUDAN UNIVERSITY   (China)

^e NONE

Author keywords

Camptothecin; Carcinoma; Epstein Barr virus; Genes, viral; Nasopharyngeal neoplasms

Indexed keywords

CAMPTOTHECIN; VIRUS PROTEIN;

APOPTOSIS; ARTICLE; CELL CYCLE S PHASE; CELL LINE; CELL PROLIFERATION; DNA DAMAGE; EPSTEIN BARR VIRUS; EXPRESSION VECTOR; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; NASOPHARYNX CARCINOMA; NONHUMAN; PROTEIN EXPRESSION;

EID: 0031461459     PISSN: 00222151     EISSN: None     Source Type: Journal    
DOI: 10.1017/S0022215100139568     Document Type: Article

References (15)

1. Cleary, M. L., Smith, S. D., Sklar, J. (1986) Cloning and structural analysis of cDNAs for bcl-2 and a hybrid bcl-2/immunoglobulin transcript resulting from the t(14;18) translocation. Cell 47: 19-28.
2. Dawson, C. W., Eliopoulos, A. G., Dawson, J., Young, L. S. (1995) BHRF1, a viral homologue of the Bcl-2 oncogene, disturbs epithelial cell differentiation. Oncogene 9: 69-77.
3. Heller, M., Dambaugh, T., Kieff, E. (1981) Epstein-Barr virus DNAIX variation among viral DNAs from producer and nonproducer infected cells. Journal of Virology 38:632-648.
4. Henderson, S., Huen, D., Rowe, M., Dawson, C., Johnson, G., Rickinson, A. (1993) Epstein-Barr virus-coded BHRF1 protein, a viral homologue of bcl-2, protects human B cells from programmed cell death. Proceedings of the National Academy of Sciences of the USA 90: 8479-8483.
5. Hickish, T. (1994) Ultrastructural localization of BHRF1: an Epstein-Barr virus gene product which has homology with bcl-2. Cancer Research 54: 2808-2811.
6. Hockenbery, D., Nunez, G., Milliman, C., Schreiber, R. D., Korsmeyer, S. J. (1990) Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death. Nature (London) 348: 334-336.
7. McDonnell, T. J., Nunez, G., Platt, F. M., Hockenberry, D., London, L., McKearn, J. P., Korsmeyer, S. J. (1990) Deregulated bcl-2-immunoglobulin transgene expands a resting but responsive immunoglobulin M- and D-expressing B-cell population. Molecular & Cellular Biology 10: 1901-1907.
8. Nunez, G., Seto, M., Seremetis, S., Ferrero, D., Grignani, F., Korsmeyer, S. J., Dalla-Favera, R. (1989) Growth and tumor-promoting effects of deregulated BCL2 in human B-lymphoblastoid cells. Proceedings of the National Academy of Sciences of the USA 86: 4589-4593.
9. Reed, J. C., Haldar, S., Cuddy, M. P., Croce, C., Makover, D. (1989) Deregulated BCL2 expression enhances growth of a human B cell line. Oncogene 4: 1123-1127.
10. Shimizu, T., Pommier, Y. (1996) DNA fragmentation induced by protease activation in p53-null human leukemia HL60 cells undergoing apoptosis following treatment with the topoisomerase I inhibitor camptothecin: cell-free system studies. Experimental Cell Research 226: 292-301.
11. Tarodi, B., Subramanian, T., Chinnadurai, G. (1994) Epstein-Barr virus BHRF1 protein protects against cell death induced by DNA-damaging agents and heterologous viral infection. Virology 201: 404-407.
12. Theodorakis, P., D'Sa-Eipper, C., Subramanian, T., Chinnadurai, G. (1996) Unmasking of a proliferation-restraining activity of the anti-apoptosis protein EBV BHRF1. Oncogens 12: 1707-1713.
13. Traganos, F., Kapuscinski, J., Gong, J., Ardelt, B., Darzynkiewicz, R. J., Darzynkiewicz, Z. (1993) Caffeine prevents apoptosis and cell cycle effects induced by camptothecin or topotecan in HL-60 cells. Cancer Research 53: 4613-4618.
14. Tsujimoto, Y. (1989) Stress-resistance conferred by high level of bcl-2-alpha protein in human B lymphoblastoid cell. Oncogene 4: 1331-1336.
15. Walton, M. I., Whysong, D., Connor, P. M., Hockenbery, D., Korsmeyer, S. J., Kohn, K. W. (1993) Constitutive expression of human Bcl-2 modulates nitrogen mustard and camptothecin induced apoptosis. Cancer Research 53: 1853-1861.