Citicoline antagonizes bromazepam-induced amnesia in rats

Human Psychopharmacology

Volumn 12, Issue 6, 1997, Pages 547-556

  Alvarez, X Antón ^a   Vecino, Begoña ^a   Perea, Juan Enrique ^b   Daniele, Danilo ^b   Cacabelos, Ramon ^a  

^a Centro de Investigacion Biomedica EuroEspes   (Spain)

^b Laboratorios Baliarda   (Argentina)

Author keywords

Acquisition; Amnesia; Bromazepam; Citicoline; Exploratory activity; Memory; Motor co ordination; Retention

Indexed keywords

BROMAZEPAM; CITICOLINE;

AMNESIA; ANIMAL EXPERIMENT; ARTICLE; CEREBROVASCULAR ACCIDENT; COGNITIVE DEFECT; CONTROLLED STUDY; DRUG MECHANISM; DRUG MIXTURE; EXPLORATORY BEHAVIOR; HEAD INJURY; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; MOTOR COORDINATION; NERVE DEGENERATION; NONHUMAN; PASSIVE AVOIDANCE; PRIORITY JOURNAL; RAT; SPATIAL DISCRIMINATION; STROKE;

EID: 0031461222     PISSN: 08856222     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1099-1077(199711/12)12:6<547::AID-HUP922>3.0.CO;2-T     Document Type: Article

References (37)

1. Agut, J., Font, E., Saladrich, J. M., Sacristán, A. and Ortiz, J. A. (1986). Acción farmacológica de la CDP-colina oral en un modelo de discinesia tardía en rata. Medicina clínica, 87 (Suppl. 1), 14-18.
2. Alvarez, X. A. and Cacabelos, R. (1993). Influence of growth hormone (GH) and GH-releasing factor on locomotor activity in rats. Peptides, 14, 707-712.
3. Alvarez, X. A., Franco, A., Fernández-Novoa, L. and Cacabelos, R. (1993). Effects of betahistine on locomotor activity and passive avoidance behavior in rats. Agents and Actions, 38, C260-262.
4. Arrigoni, E., Averet, N. and Cohadon, F. (1987). Effects of CDP-choline on phospholipase A2 and choline-phosphotransferase activities following a cryogenic brain injury in the rabbit. Biochemical Pharmacology, 36, 3697-3700.
5. Barbee, J. G. (1993). Memory, benzodiazepines, and anxiety: integration of theoretical and clinical perspectives. Journal of Clinical Psychiatry, 54, 86-97.
6. Bourin, M., Hascoet, M., Mansouri, B., Colombel, M. C. and Bradwein, J. (1992). Comparison of behavioral effects after single and repeated administration of four benzodiazepines in three mice behavioral models. Journal of Psychiatry and Neuroscience, 17, 72-77.
7. Cacabelos, R., Alvarez, X. A., Franco-Maside, A., Fernández-Novoa, L. and Caamaño, J. (1993). Effect of CDP-choline on cognition and immune function in Alzheimer's disease and multi-infarct dementia. Annals of the New York Academy of Sciences, 695, 321-323.
8. Cacabelos, R., Caamaño, J., Gómez, M. J., Fernández-Novoa, L., Franco-Maside, A. and Alvarez, X. A. (1996). Therapeutic effects of CDP-choline in Alzheimer's disease. Cognition, brain mapping, cerebrovascular hemodynamics, and immune factors. Annals of the New York Academy of Sciences, 777, 399-403.
9. Cacabelos, R., Niigawa, H., Hariguchi, S. and Nishimura, T. (1987). Influence of somatostatin and growth hormone-releasing factor on locomotion and learning in rats. OUCEM-86: A computerized system to study behavioral parameters in small mammals. Progress in Medicine, 7, 763-773.
10. Cacabelos, R., Nordberg, A., Caamaño, J., Franco-Maside, A. Fernández-Novoa, L., Gómez, M. J., Alvarez, X. A., Takeda, M., Prous, J. Jr., Nishimura, T. and Winblad, B. (1994). Molecular strategies for the first generations of antidementia drugs (I). Tacrine and related compounds. Drugs Today, 30, 295-337.
11. Cervós-Mavarro, J. and Lafuente, J. V. (1990). Effect of cytidine diphosphate choline on ultraviolet-induced brain edema. Advances in Neurology, 52, 421-429.
12. Chandra, B. (1992). Treatment of multi-infarct dementia with citicholine. Journal of Stroke and Cerebrovascular Diseases, 2, 232-233.
13. Cole, B. J. and Hillmann, M. (1994). Effects of benzodiazepine receptor ligands on the performance of an operant delayed matching to position task in rats: opposite effects of FG 7142 and lorazepam. Psychopharmacology, 115, 350-357.
14. Dorman, R. V., Dabrowiecki, Z. and Horrocks, L. A. (1983). Effects of CDPcholine and CDPethanolamine on the alterations in rat brain lipid metabolism induced by global ischemia. Journal of Neurochemistry, 40, 276-279.
15. Drago, F., Mauceri, F., Nardo, L., Valerio, C., Genazzani, A. A. and Grassi, M. (1993). Effects of cytidine-diphosphocholine on acetylcholine-mediated behaviors in the rat. Brain Research Bulletin, 31, 485-489.
16. File, S. E., Mabbutt, P. S., Bontempi, B., Destrade, C. and Jaffard, R. (1993). Effects of S 9977 on learning and memory in the mouse and rat. Drug Development Research, 28, 478-487.
17. Galletti, P., De Rosa, M., Cotticelli, M. G., Morana, A., Vaccaro, R. and Zappia, V. (1991). Biochemical rationale for the use of CDP-choline in traumatic brain injury: Pharmacokinetics of the orally administered drug. Journal of Neurological Science, 103, S19-S25.
18. 2+. Journal of Biological Chemistry, 266, 12419-12423.
19. Giménez, R., Raïch, J. and Aguilar, J. (1991). Changes in brain striatum dopamine and acetylcholine receptors induced by chronic CDP-choline treatment in aging mice. British Journal of Pharmacology, 104, 575-578.
20. Izquierdo, I., Medina, J. H., Bianchin, M., Walz, R., Zanatta, M. S., Da Silva, R. C., Bueno e Silva, M., Ruschel, A. C. and Paczko, N. (1993). Memory processing by the limbic system: role of specific neurotransmitter systems. Behavioral Brain Research, 58, 91-98.
21. Kakihana, M., Fukuda, N., Suno, M. and Nagaoka, A. (1988). Effects of CDP-choline on neurologic deficits and cerebral glucose metabolism in a rat model of cerebral ischemia. Stroke, 19, 217-222.
22. Martinet, M., Fonlupt, P. and Pacheco, H. (1979). Effects of cytidine-5′ diphosphocholine on norepinephrine, dopamine and serotonin synthesis in various regions of the rat brain. Archives Internationales de Pharmacodynamie et de therapre, 239, 52-61.
23. Masi, I., Giani, E. and Galli, C. (1986). Effects of CDP-choline on platelet aggregation and the antiaggregatory activity of arterial wall in the rat. Pharmacological Research Communications, 18, 273-281.
24. Mosharrof, A. H. and Petkov, V. D. (1990). Effects of citicholine and of the combination citicholine + piracetam on the memory (experiments on mice). Acta Physiologica et Pharmacologica Bulgarica, 16, 25-31.
25. Petkov, V. D., Mosharrof, A. H., Kehayov, R., Petkov, V. V., Konstantinova, E. and Getova, D. (1991). Effect of CDP-choline on learning and memory processes in rodents. Methods and Findings in Experimental and Clinical Pharmacology, 14, 593-605.
26. Petkov, V. D., Stancheva, S. L., Tocuschieva, L. and Petkov, V. V. (1990). Changes in brain monoamines induced by nootropic drugs adafenoxate and meclofenoxate and by citicholine (experiments on rats). General Pharmacology, 21, 71-75.
27. Porsolt, R. D., Lenègre, A., Avril, I. and Doumont, G. (1988). Antagonism by oxifene, a new cognitive enhancing agent, of the amnesia induced by four benzodiazepines in mice. Psychopharmacology, 95, 291-297.
28. Prather, P. L., Forster, M. J. and Lal, H. (1992). Learning and memory-enhancing effects of Ro 15-4513: a comparison with flumazenil. Neuropharmacology, 31, 299-306.
29. Rummans, T. A., Davis, L. J. Jr., Morse, R. M. and Ivnik, R. J. (1993). Learning and memory impairment in older, detoxified, benzodiazepine-dependent patients. Mayo Clinic Proceedings, 68, 731-737.
30. Sanger, D. J., Benavides, J., Perrault, G., Morel, E., Cohen, C., Joly, D. and Zivkovic, B. (1994). Recent developments in the behavioral pharmacology of benzodiazepine (omega receptors: evidence for the functional significance of receptor subtypes). Neuroscience and Biobehavioral Reviews, 18, 355-372.
31. Suryani, L. K., Adnjana, T. A. K. and Jensen, G. D. (1988). Citicoline treatment of memory deficits in elderly people. International Journal of Geriatric Psychiatry, 3, 235-236.
32. Tata, P. R., Rollings, J., Collins, M., Pickering, A. and Jacobson, R. R. (1994). Lack of cognitive recovery following withdrawal from long-term benzodiazepine use. Psychological Medicine, 24, 203-213.
33. Tazaki, Y., Sakai, F., Otomo, E., Kutsuzawa, T., Kameyama, M., Omae, T., Fujishima, M. and Sakuma, A. (1988). Treatment of acute cerebral infarction with a choline precursor in a multicenter double-blind placebo-controlled study. Stroke, 19, 211-216.
34. Tomaz, C., Dickinson-Anson, H., McGaugh, J. L., Souza-Silva, M. A., Viana, M. B. and Graeff, F. G. (1993). Localization in the amygdala of the amnestic action of diazepam on emotional memory. Behavioral Brain Research, 58, 99-105.
35. Tonne, U., Hiltunen, A. J., Vikander, B., Engelbrektsson, K., Bergman, H., Bergman, I., Leifman, H. and Borg, S. (1995). Neuropsychological changes during steady-state drug use, withdrawal and abstinence in primary benzodiazepine-dependent patients. Acta Psychiatrica Scandinavica, 91, 299-304.
36. Trovarelli, G., Palmerini, C. A., Floridi, A., Piccini, G. L. and Porcellati, G. (1984). The influence of cytidine on the endogenous pool of CDP-choline, CDP-ethanolamine, and cAMP of the rat brain. Neurochemistry Research, 9, 73-79.
37. Wurtman, R. J., Blusztajn, J. K., Ulus, I. H., Coviella, I. L. G., Buyukuysal, R. L., Growdon, J. H. and Slack, B. E. (1990). Choline metabolism in cholinergic neurons: Implications for the pathogenesis of neurodegenerative diseases. Advances in Neurology, 51, 117-125.