Chronic obstructive pulmonary disease from science to the clinic: The role of glutathione in oxidant-antioxidant balance

Monaldi Archives for Chest Disease

Volumn 52, Issue 5, 1997, Pages 479-485

  MacNee, W ^a  

^a Respiratory Medicine   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; ANTIINFLAMMATORY AGENT; ANTIOXIDANT; CELL ADHESION MOLECULE; CIGARETTE SMOKE; CYTOKINE; GLUTATHIONE; IMMUNOMODULATING AGENT; INTERLEUKIN 8; LEUKOTRIENE B4; OXIDIZING AGENT; OXYGEN RADICAL; PROTEINASE; PROTEINASE INHIBITOR;

ANTIOXIDANT ACTIVITY; CHRONIC OBSTRUCTIVE LUNG DISEASE; CIGARETTE SMOKING; DRUG TARGETING; GENETIC MANIPULATION; GLUTATHIONE METABOLISM; HUMAN; INFLAMMATION; LEUKOCYTE MIGRATION INHIBITION; LUNG CIRCULATION; MUCOLYSIS; NEUTROPHIL; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PATHOGENESIS; PATIENT; PNEUMONIA; REVIEW; TREATMENT PLANNING;

EID: 0031460967     PISSN: 11220643     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (2)

1. Church T, Pryor WA. - Free-radical chemistry of cigarette smoke and its toxicological implications. Environ Health Perspect 1985; 64: 111-126.
2. Hubbard RC, Ogushi F, Fels GA, Cantin AM, Courtney M, Crystal RG. - Oxidants spontaneously released by alveolar macrophages of cigarette smokers can inactivate the active site of alpha 1-antitrypsin, rendering it ineffective as an inhibitor of neutrophil elastase. J Clin Invest 1987; 80: 1289-1295.