Protein kinase inhibitors abolish adaptative cell behaviour in Tetrahymena

Acta Protozoologica

Volumn 36, Issue 4, 1997, Pages 249-260

  Leick, Vagn ^a   Iversen, Charlotte ^a   Kemp, Kåre ^a   Christensen, Søren T ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Adaptation; Chemoattraction; Protein kinase inhibitors; Tetrahymena

Indexed keywords

EID: 0031460294     PISSN: 00651583     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Almagor M., Ron A., Bar-Tana J. (1981) Chemotaxis in Tetrahymena thermophila. Cell Motility 1: 261-268
2. Christensen S. T., Rasmussen L., Leick V, Wheatley D. N. (1997) Signalling in unicellular eukaryotes. Regulation of cell survival, differentiation, mating, chemosensory behaviour and programmed cell death. Int. Rev. Cytol. (in press)
3. Ferrell J. E. (1996) Tripping the switch fantastic: how a protein cascade can convert graded inputs into switch-like outputs. Trends in Biochemical Sciences. 21: 460-466
4. Gazit A., Yaish P., Gilon C., Levitzki A. (1989) Tyrphostins I: synthesis and biological activity of protein kinase inhibitors. J. Med. Chem. 32: 2344-2352
5. Hufnagel L. A. (1992) Cortical ultrastrucure and chemoreception in ciliated protists (Ciliophora). Microcop. Res. and Technique 22: 225-264
6. Johnston J. A., Ferris D. K., Wang J. M., Longo D. L., Oppenheim J. J., Kelvin D. J. (1994) Staurosporine restores signaling and inhibits interleukin-8-induced chemotactic desensitization. Eur. J. Immunol. 24: 2556-2562
7. Koppelhus U., Hellung-Larsen P., Leick V. (1994) An improved quantitative assay for chemokinesis in Tetrahymena. Biol. Bull. 187: 8-15
8. Köhidai L., Karsa J., Csaba G. (1994) Effect of hormones on chemotaxis in Tetrahymena: investigestions on receptor memory. Microbios 77: 75-85
9. Leick V. , Hellung-Larsen P. (1985) Chemosensory responses in Tetrahymena: The involvement of peptides and other signal substances. J. Protozool. 32: 550-553
10. Leick V., Koppelhus U., Rosenberg J. (1994) Cilia-mediated oriented chemokinesis in Tetrahymena thermophila. J. Euk. Microbiol. 41:546-553
11. Leick V., Grave M., Hellung-Larsen P. (1996) Signal peptide-induced chemosensory behaviour in free ciliates: Bioassays and cellular mechanisms. Progress in molecular and subcellular biology (Eds. G. Csaba and W.E.G. Müller) Springer Verlag/Heidelberg 17: 61-66
12. Menco B. Ph. M. (1992) Ultrastructural studies on membrane, cytoskeletal, mucous, and protective compartments in olphactation. Microscop. Res. Techn 22: 215-224
13. Morimoto B. H., Koshland D. E. Jr. (1991) Short-term and long-term memory in single cells. FASEB Journal 5: 2061-2067
14. Ramdas L., McMurray J. S., Budde R. J. (1994) The degree of inhibition of protein tyrosine kinase activity by tyrphostin 23 and 25 is related to their instability. Cancer Res 54: 867-869
15. Satir P., Barkalow K., Hamasaki T. (1993) The control of ciliary beat frequency. Trends in Cell Biology. 3: 409-412
16. Shimokado K., Yokota T., Kosaka C., Zen K., Sasaguri T., Masuda J., Ogata J. (1995) Protein tyrosine kinase inhibitors inhibit both proliferation and chemotaxis of vascular smooth muscle cells. Ann. N Y Acad. Sci. 748: 171-175
17. Straarup E. M., Schousboe P., Christensen S. T., Quie H., Kristiansen K., Rasmussen L. (0000) Effects of protein kinase C activators and staurosporine on cell survival and protein kinase activity in Tetrahymena thermophila. (Submitted for publication)
18. Tamaoki T. (1991) Use and specificity of stauroporine, UCN-01, and calphostin C as protein kinase inhibitors. Methods in Enzymology 201: 340-347
19. Takuma T., Tajima Y., Ischida T. (1996) Effect of genistein on amylase release and protein tyrosine phosphorylation in parotid acinar cells. FEBS letters 380: 83-36
20. Wheatley D. N., Rasmussen L., Tiedtke A. (1994) Tetrahymena: a model for growth, cell cycle, and nutritional studies, with biotechnological potential. Bioessays 16: 367-371