Involvement of alpha-2 adrenoceptors in the effects of moxonidine on intestinal motility and fluid transport

Journal of Pharmacology and Experimental Therapeutics

Volumn 283, Issue 3, 1997, Pages 1367-1374

  Liu, Lu ^a   Coupar, Ian M ^a  

^a MONASH UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

2 ETHOXY 1(2H) QUINOLINECARBOXYLIC ACID ETHYL ESTER; AGMATINE; ALPHA 2 ADRENERGIC RECEPTOR; BRIMONIDINE; EFAROXAN; MOXONIDINE; YOHIMBINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG SELECTIVITY; FLUID TRANSPORT; GASTROINTESTINAL MOTILITY; MALE; NONHUMAN; PERISTALSIS; PRIORITY JOURNAL; RAT; RECEPTOR AFFINITY;

AGMATINE; ANIMALS; BODY WATER; DOSE-RESPONSE RELATIONSHIP, DRUG; GASTROINTESTINAL MOTILITY; IMIDAZOLES; MALE; PERISTALSIS; QUINOLINES; QUINOXALINES; RATS; RATS, WISTAR; RECEPTORS, ADRENERGIC, ALPHA-2; VASOACTIVE INTESTINAL PEPTIDE; YOHIMBINE;

EID: 0031459936     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (52)

1. ALLAN, D. R., PENNER, S. B. AND SMYTH, D. D.: Renal imidazoline preferring sites and solute excretion in the rat. Br. J. Pharmacol. 108: 870-875, 1993.
2. ANDREJAK, M., POMMIER, Y., MOUILLE, P. AND SCHMITT, H.: Effects of some α-adrenoceptor agonists and antagonists on the guinea pig ileum. Naunyn-Schmiedeberg's Arch. Pharmacol. 314: 83-87, 1980.
3. BERDEU, D., PUECH, R., LOUBATIERES-MARIANI, M. AND BERTRAND, G.: Agmatine is not a good candidate as endogenous ligand for imidazoline sites of pancreatic B cells and vascular bed. Eur. J. Pharmacol. 308: 301-304, 1996.
4. BOUSQUET, P., FELDMAN, J. AND SCHWARTZ, J.: Central cardiovascular effects of alpha adrenergic drugs: Differences between catecholamines and imidazolines. J. Pharmacol. Exp. Ther. 230: 232-236, 1984.
5. 3H]-clonidine to identify imidazoline receptors in the rabbit brainstem. Br. J. Pharmacol. 110: 1537-1543, 1993.
6. BYLUND, D. B.: Pharmacological characteristics of alpha-2 adrenergic receptor subtypes. Ann. N. Y. Acad. Sci. 763: 1-7, 1995.
7. 2-agonist for the characterization of α-adrenoceptor subtypes. Eur. J. Pharmacol. 72: 413-415, 1981.
8. CARLISLE, M. A., SMYTH, D. D. AND GLAVIN, G. B.: Efaroxan acts peripherally to block the antisecretory and gastroprotective effects of moxonidine in rats. J. Pharmacol. Exp. Ther. 274: 598-601, 1995.
9. COUPAR, I. M.: Choice of anaesthetic for intestinal absorption and secretion experiments using rats. J. Pharmacol. Methods 13: 311-338, 1985.
10. COUPAR, I. M.: The peristaltic reflex in the rat ileum: Evidence for functional μ and δ-opiate receptors. J. Pharm. Pharmacol. 47: 643-646, 1995.
11. COUPAR, I. M. AND LIU, L.: A simple method for measuring the effects of drugs on intestinal longitudinal and circular muscle. J. Pharmacol. Toxicol. Methods 36: 147-154, 1996.
12. DOHERTY, N. S. AND HANCOCK, A. A.: Role of alpha-2 adrenergic receptors in the control of diarrhea and intestinal motility. J. Pharmacol. Exp. Ther. 225: 269-274, 1983.
13. 1-imidazoline sites. J. Pharmacol. Exp. Ther. 264: 172-182, 1993.
14. ERNSBERGER, P., GIULIANO, R., WILLETTE, R. N. AND REIS, D. J.: Role of imidazole receptors in the vasodepressor response to clonidine analogs in the rostral ventrolateral medulla. J. Pharmacol. Exp. Ther. 253: 408-418, 1990.
15. 2-adrenoceptors in the ventrolateral medulla. Eur. J. Pharmacol. 131: 1-13, 1987.
16. 1-imidazoline receptors. J. Cardiovasc. Pharmacol. 20 (Suppl. 4): S1-S10, 1992.
17. 2-adrenoceptors. Br. J. Pharmacol. 116: 1557-1570, 1995.
18. FURCHGOTT, R. F.: The classification of adrenoceptors (adrenergic receptors): An evaluation from the stand-point of receptor theory. In Handbook of Experimental Pharmacology: Catecholamines. ed. by H. Blaschko and E. Muscholl, Vol. 33, pp. 283-335, New Series, Springer-Verlag, Berlin, 1972.
19. GLAVIN, G. B., CARLISLE, M. A. AND SMYTH, D. D.: Agmatine, an endogenous imidazoline receptor agonist, increases gastric secretion and worsens experimental gastric mucosal injury in rats. J. Pharmacol. Exp. Ther. 274: 741-744, 1995.
20. 1 imidazoline receptor agonist, moxonidine, on gastric secretion and gastric mucosal injury in rats. Br. J. Pharmacol. 114: 751-754, 1995.
21. GOLDBERG, M. R. & ROBERTSSON, D.: Yohimbine: A pharmacological probe for study of the alpha2-adrenoceptor. Pharmacol. Rev. 35: 143-180, 1983.
22. GONZALEZ, C., REGUNATHAN, S., REIS, D. J. AND ESTRADA, C.: Agmatine, an endogenous modulator of noradrenergic neurotransmission in the rat tail artery. Br. J. Pharmacol. 119: 677-684, 1996.
23. 3H]idazoxan bind to different sites on rabbit forebrain and kidney membranes. Eur. J. Pharmacol. 146: 345-348, 1988.
24. HANCOCK, D. L. AND COUPAR, I. M.: Involvement of adenosine in the antisecretory action of morphine. Gen. Pharmacol. 28: 709-713, 1997.
25. 1-imidazoline receptors in the rostral ventrolateral medulla. J. Cardiovasc. Pharmacol. 24 (Suppl. 1): S1-S8, 1994.
26. HEAD, G. A.: Importance of imidazoline receptors in the cardiovascular actions of centrally acting antihypertensive agents. Ann. N. Y. Acad. Sci. 763: 531-540, 1995.
27. 2-adrenoceptors. Br. J. Parmacol. 110: 1635-1639, 1993.
28. HOLT A. AND BAKER, G. B.: Metabolism of agmatine (clonidine-displacing substance) by diamine oxidase and the possible implications for studies of imidazoline receptors. Prog. Brain Res. 106: 187-197, 1995.
29. LI, G., REGUNATHAN, S., BARROW, C. J., ESHRAGHI, J., COOPER, R. AND REIS, D. J.: Agmatine: An endogenous clonidine-displacing substance in the brain. Science 263: 966-969, 1994.
30. 2D-adrenoceptors in the rat intestine. Br. J. Pharmacol. 117: 787-792, 1996.
31. 2-adrenoceptors in the regulation of intestinal water transport. Br. J. Pharmacol. 120: 892-898, 1997.
32. MICHEL, M. C. AND INSEL, P. A.: Are there multiple imidazoline binding sites? Trends Pharmacol. Sci. 10: 342-344, 1989.
33. 14C and effects of perfusion techniques. Gastroenterology 62: 45-48, 1972.
34. 2-imidazoline binding sites. Naunyn-Schmiedebergs Arch. Pharmacol. 351: 507-516, 1995.
35. 3H]RX821002 and distribution along the villus-crypt axis. J. Pharmacol. Exp. Ther. 254: 888-893, 1990.
36. 1 imidazoline receptor agonist, moxonidine. Br. J. Pharmacol. 112: 1089-1094, 1994.
37. PILETZ, J. E., CHIKKALA, D. N. AND ERNSBERGER, P.: Comparison of the properties of agmatine and endogenous clonidine-displacing substance at imidazoline and alpha-2 adrenergic receptors. J. Pharmacol. Exp. Ther. 272: 581-587, 1995.
38. PINEDA, J. UGEDO, L. AND GARCIA-SEVILLA, J. A.: Stimulatory effects of clonidine, cirazoline and rilmenidine on locus coeruleus noradrenergic neurones: Possible involvement of imidazoline-preferring receptors. Naunyn-Schmiedeberg's Arch Pharmacol. 348: 134-140, 1993.
39. 2-adrenoceptors. Naunyn-Schmiedeberg's Arch Pharmacol. 351: 10-16, 1995.
40. RAASCH, W., REGUNATHAN, S. LI, G. AND REIS, D.: Agmatine is widely and unequally distributed in rat organs. Ann. N. Y. Acad. Sci. 763: 330-334, 1995.
41. REGUNATHAN, S. AND REIS, D. J.: Imidazoline receptors and their endogenous ligands. Annu. Rev. Pharmacol. Toxicol. 36: 511-544, 1996.
42. RUIZ-ORTEGA, J. A., UGEDO, L., PINEDA, J. AND GARCIA-SEVILLA, J. A.: The stimulatory effect of clonidine through imidazoline receptors on locus coeruleus noradrenergic neurones is mediated by excitatory amino acids and modulated by serotonin. Naunyn-Schmiedeberg's Arch Pharmacol. 352: 121-126, 1995.
43. 2-adrenoceptors and non-adrenergic idazoxan binding sites in rabbit colon epithelial cells. Eur. J. Pharmacol. 191: 59-68, 1990.
44. SMYTH, D. D., LI, P., BLANDFORD, D. E. AND PENNER, S. B.: Opposite rank order of potency for alpha-2 adrenoceptor agonists on water and solute excretion in the rat: Two sites and/or receptors? J. Pharmacol. Exp. Ther. 261: 1080-1086, 1992.
45. SZABO, B., FROHLICH, R. AND ILLES, P.: No evidence for functional imidazoline receptors on locus coeruleus neurons. Naunyn-Schmiedeberg's Arch Pharmacol. 353: 557-563, 1996.
46. 2-adrenoceptors. Naunyn-Schmiedeberg's Arch. Pharmacol. 348: 593-600, 1993.
47. TALLARIDA, R. J. AND MURRAY, R. B: Manual of Pharmacologic Calculations with Computer Programs. Springer-Verlag, Berlin, 1987.
48. TIBIRICA, E., FELDMAN, J., MERMET, C., GONON, F. AND BOUSQUET, P.: An imidazoline-specific mechanism for the hypotensive effect of clonidine: A study with yohimbine and idazoxan. J. Pharmacol. Exp. Ther. 256: 606-613, 1991.
49. URBAN, R., SZABO, B. AND STARKE, K.: Is the sympathoinhibitory effect of rilmenidine mediated by alpha-2 adrenoceptors or imidazoline receptors? J. Pharmacol. Exp. Ther. 270: 572-578, 1994.
50. 2-adrenoceptors in the cardiovascular effects of moxonidine. Eur. J. Pharmacol. 282: 19-28, 1995.
51. WELSH, M. J., SMITH, P. L., FROMM, M. AND FRIZZELL, R. A.: Crypts are the site of intestinal fluid and electrolyte secretion. Science 218: 1219-1221, 1982.
52. WIKBERG, J.: Localization of adrenergic receptors in guinea pig ileum and rabbit jejunum to cholinergic neurons and to smooth muscle cells. Acta Physiol. Scand. 99: 190-207, 1977.