Utility of in vitro heparin and protamine titration for dosing during cardiopulmonary bypass surgery

Journal of Extra-Corporeal Technology

Volumn 29, Issue 4, 1997, Pages 176-180

  Zucker, M L ^a   Barrett, C L ^a   Bennett, K ^a   LaDuca, F M ^a  

^a International Technidyne Corporation   (United States)

Author keywords

Cardiopulmonary bypass; Dosing; Titration

Indexed keywords

HEPARIN; PROTAMINE;

ADULT; AGED; ARTICLE; CARDIOPULMONARY BYPASS; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE CALCULATION; FEMALE; HEPARINIZATION; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; MALE; MULTICENTER STUDY; PREDICTION; THROMBOSIS; TITRIMETRY;

EID: 0031458926     PISSN: 00221058     EISSN: 29698960     Source Type: Journal    
DOI: None     Document Type: Article

References (10)

1. Bull BS, Korpman RA, Huse WM. Briggs BD. Heparin therapy during extracorporeal circulation: I- Problems inherent in existing heparin protocols. J Thorac Cardiovasc Surg. 1975; 69: 674-684.
2. Bull BS, Huse WM, Brauer FS, Korpman RA. Heparin therapy during extracorporeal circulation: II- The use of a dose-response curve to individualize heparin and protamine dosage. J Thorac Cardiovasc Surg. 1975; 69: 685-689.
3. Jobes JR, Aitkin GL, Shaffer GW. Increased accuracy and precision of heparin and protamine dosing reduces blood loss and transfusion in patients undergoing primary cardiac operations. J Thorac Cardiovasc Surg 1995; 110: 36-45.
4. Horrow JC. Protamine: A review of its toxicity. Anesth Analg. 1985; 64: 348-361.
5. Levinson MM, Ohm W. The pathophysiology and treatment of severe protamine reactions in cardiovascular surgery. The Heart Surgery Forum. 1995; No. 0603.
6. Jobes DR, Etzioni DA, Stepsis LH, et al. Cost-effective management of heparin/protamine in cardiopulmonary bypass: Analysis by type of surgery. Anesthesiology. 1996; 85: A147.
7. Mabry CD, Thompson BW, Read RC. Campbell GS. Activated clotting time monitoring of intraoperative heparinization: Our experience and comparison of two techniques. Surgery. 1981; 90:889-895.
8. Effeney DJ, Goldstone J, Chin D, Krupski WC, Ellis RJ. Intraoperative anticoagulation in cardiovascular surgery. Surgery. 1981; 90: 1069-1074.
9. Nyhan D, Thompson S, Harple M. Improved post-operative management following cardiopulmonary bypass using in vitro heparin and protamine dosing assays. Soc Proc Cardiovasc Anesth 14th Annual Mtg. 1992; 290.
10. DeLaria GA, Tyner JJ, Hayes CL, Armstrong BW. Heparin-protamine mismatch: A controllable factor in bleeding after open heart surgery. Arch Surg. 1994; 129: 945-951.