(Aryloxy)alkylamines as selective human dopamine D4 receptor antagonists: Potential antipsychotic agents

Journal of Medicinal Chemistry

Volumn 40, Issue 25, 1997, Pages 4026-4029

  Unangst, Paul C ^a   Capiris, Thomas ^a   Connor, David T ^a   Doubleday, Robert ^a   Heffner, Thomas G ^a   MacKenzie, Robert G ^a   Miller, Steven R ^a   Pugsley, Thomas A ^a   Wise, Lawrence D ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

(ARYLOXY)ALKYLAMINE DERIVATIVE; 3 [[4 (4 CHLOROPHENYL) 1 PIPERAZINYL]METHYL] 1H PYRROLO[2,3 B]PYRIDINE; BENZENESULFONAMIDE DERIVATIVE; DOPAMINE 4 RECEPTOR; DOPAMINE RECEPTOR BLOCKING AGENT; NEUROLEPTIC AGENT; QUINPIROLE; RECEPTOR SUBTYPE; SONEPIPRAZOLE; UNCLASSIFIED DRUG;

ARTICLE; CHO CELL; DOPAMINE RECEPTOR BLOCKING; HUMAN; HUMAN CELL; HUMAN TISSUE; PSYCHOSIS; RECEPTOR AFFINITY; RECEPTOR BINDING; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTIPSYCHOTIC AGENTS; CHO CELLS; CRICETINAE; DOPAMINE ANTAGONISTS; HUMANS; RECEPTORS, DOPAMINE D2; RECEPTORS, DOPAMINE D4; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0031458279     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm970422s     Document Type: Article

References (21)

1. Reynolds, G. P. Developments in the Drug Treatment of Schizophrenia. Trends Pharmacol. Sci. 1992, 13, 116-121.
2. Seeman, P. Dopamine Receptors and the Dopamine Hypothesis of Schizophrenia. Synapse 1987, 1, 133-152.
3. Civelli, O.; Bunzow, J. R.; Grandy, D. K.; Zhou, Q.-Y.; Van Tol, H. H. M. Molecular Biology of the Dopamine Receptors. Eur. J. Pharmacol.-Mol. Pharmacol. Sect. 1991, 207, 277-286.
4. 4. Neuropsychopharmacology 1992, 7, 261-284.
5. 4 Receptor with High Affinity for the Antipsychotic Clozapine. Nature 1991, 350, 610-614.
6. Schwartz, J. T.; Brotman, A. W. A Clinical Guide to Antipsychotic Drugs. Drugs 1992, 44, 981-992.
7. 4 Receptors and Their Antagonists. Med. Res. Rev. 1996, 16, 507-526.
8. 4 Receptor Selective Antagonist. J. Pharmacol. Exp. Ther. 1996, 279, 1392-1403.
9. 4 Receptor. J. Med. Chem. 1996, 39, 1941-1942.
10. Thurkauf, A.; Yuan, J.; Chen, X.; Wasley, J. W. F.; Meade, R.; Woodruff, K. H.; Huston, K.; Ross, P. C. 1-Phenyl-3-(aminomethyl)pyrroles as Potential Antipsychotic Agents. Synthesis and Dopamine Receptor Binding. J. Med. Chem. 1995, 38, 4950-4952.
11. 4 Antagonists. J. Med. Chem. 1996, 39, 1946-1948.
12. Rowley, M.; Collins, I.; Broughton, H. B.; Davey, W. B.; Baker, R.; Emms, F.; Marwood, R.; Patel, S.; Patel, S.; Ragan, C. I.; Freedman, S. B.; Ball, R.; Leeson, P. D. 4-Heterocyclylpiperidines as Selective High-Affinity Ligands at the Human Dopamine D4 Receptor. J. Med. Chem. 1997, 40, 2374-2385.
13. 4 Receptor Antagonists as Potential Antipsychotic Agents. J. Med. Chem. 1997, 40, 2688-2693.
14. 3 Agonist PD128907. J. Pharmacol. Exp. Ther. 1995, 275, 1355-1366.
15. 4 Receptor Antagonists: Synthesis and Structure-Activity Relationships of (S)-(+)-N-(1-Benzyl-3-pyrrolidinyl)-5-chloro-4-[(cyclopropylcarbonyl)amino]-2- methoxybenzamide (YM-43611) and Related Compounds. J. Med. Chem. 1996, 39, 2764-2772.
16. 2 Dopamine Receptors. Mol. Pharmacol. 1994, 45, 51-60.
17. Soffer, L. M.; Parrotta, E. W. The Cleavage of β-Oxypropionitriles with Lithium Aluminum Hydride. J. Am. Chem. Soc. 1954, 76, 3580-3583.
18. Eli Lilly and Co. Derivatives of Cyclopropylamine. French Patent 1,481,052, 1967.
19. Mahajan, R. K.; Bhardwaj, R.; Malhotra, R. K. Juvenile Hormone Like Substances-Part VIII: Synthesis of (6-Methyl-3-aza-4-oxo-5-heptenyloxy)benzene and Related Compounds. Proc. Nat. Acad. Sci. India 1992, 62(A), 131-136.
20. Reinholz, E.; Becker, A.; Hagenbruch, B.; Schäfer, S; Schmitt, A. Selectivity in Alkylation of Phenols with 1-Bromo-3-chloropropane using Phase-Transfer Catalysis. Synthesis 1990, 1069-1071.
21. Collins, M. J.; Gready, J. E.; Sternhell, S.; Tansey, C. W. An N. M. R. Investigation of the Mills-Nixon Effect. Aust. J. Chem. 1990, 43, 1547-1557.