Brain-derived neurotrophic factor fails to arrest neuromuscular disorders in the paralyse mouse mutant, a model of motoneuron disease

Journal of the Neurological Sciences

Volumn 153, Issue 1, 1997, Pages 20-24

  Blondet, Brigitte ^a,b   Murawsky, Monique ^a   Houenou, Lucien J ^c   Linxi Li, ^c   Aït Ikhlef, Ali ^a   Yan, Qiao ^d   Rieger, François ^a  

^a INSERM   (France)

^b UNIVERSITÉ PARIS EST CRÉTEIL   (France)

^c WAKE FOREST SCHOOL OF MEDICINE   (United States)

^d AMGEN INC   (United States)

Author keywords

Brain derived neurotrophic factor; Motoneuron disease; Mutant mouse; Paralyse mouse; Spinal Muscular Atrophy; Trophic factors

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; CHOLINE ACETYLTRANSFERASE; PLACEBO;

ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; GENE MUTATION; MOTOR NEURON DISEASE; MOUSE; NEUROMUSCULAR DISEASE; NONHUMAN; PARALYSIS; PRIORITY JOURNAL; SKELETAL MUSCLE; SPINAL MUSCULAR ATROPHY; SUBCUTANEOUS DRUG ADMINISTRATION;

ANIMALS; BODY WEIGHT; BRAIN-DERIVED NEUROTROPHIC FACTOR; CHOLINE O-ACETYLTRANSFERASE; MICE; MICE, NEUROLOGIC MUTANTS; MOTOR NEURON DISEASE; MOTOR NEURONS; MUSCULOSKELETAL EQUILIBRIUM; NEUROMUSCULAR DISEASES; PARALYSIS; SURVIVAL ANALYSIS;

EID: 0031457898     PISSN: 0022510X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-510X(97)00171-8     Document Type: Article

References (19)

1. Blondet B., Duxon M.J., Harris A.J., Melki J., Guénet J.L., Pinçon-Raymond M., Rieger F. Nerve and muscle development in paralysé mutant mice. Dev. Biol. 132:1989;153-166.
2. Curtis R., Di Stefano P.S. Neurotrophic factors, retrograde axonal transport and cell signalling. Trends Cell Biol. 4:1994;383-386.
3. Dittrich F., Ochs G., Grosse-Wilde A., Berweiler U., Yan Q., Miller J.A., Toyka K.V., Sendtner M. Pharmacokinetics of intrathecally applied BDNF and effects on spinal motoneurons. Exp. Neurol. 141:1996;225-239.
4. Duchen L.W., Gomez S., Guénet J.L., Love S. Paralysé: a new neurological mutant mouse with progressive atrophy and loss of motor nerve terminals (Abstract). J. Physiol. (Lond.). 345:1983;166P.
5. Fonnum F. A rapid radiochemical method for the determination of choline-acetyltransferase. J. Neurochem. 24:1975;407-409.
6. Hantaï D., Akaaboune M., Lagord C., Murawsky M., Houenou L.J., Festoff B.W., Vaught J.L., Rieger F., Blondet B. Beneficial effects of insulin-like growth factor-I on wobbler mouse motoneuron disease. J. Neurol. Sci. 129(Suppl.):1995;122-126.
7. Henderson C.E., Phillips H.S., Pollock R.A., Davies A.M., Lemeulle C., Armanini M., Simpson L.C., Moffet B., Vandlen R.A., Koliatsos V., Rosenthal A. GDNF: a potent survival factor for motoneurons present in peripheral nerve and muscle. Science. 266:1994;1062-1064.
8. Houenou L.J., Blondet B., Li L., Murawsky M., Oppenheim R., Rieger F. The paralysé mouse mutant: a new animal model of anterior horn motor neuron degeneration. J. Neuropathol. Exp. Neurol. 55:1996;698-703.
9. Koliatsos V.E., Clatterbuck R.E., Winslow J.W., Cayouette M.H., Price D.L. Evidence that brain-derived neurotrophic factor is a trophic factor for motor neurons in vivo. Neuron. 10:1993;359-367.
10. Lewin B. Genes for SMA: Multum in Parvo. Cell. 80:1995;1-5.
11. Li L., Oppenheim R.W., Lei M., Houenou L.J. Neurotrophic agents prevent motoneuron death following sciatic nerve section in the neonatal mouse. J. Neurobiol. 25:1994;759-766.
12. Mitsumoto H., Ikeda K., Klinkosz B., Cedarbaum J.M., Wong V., Lindsay R.M. Arrest of motor neuron disease in wobbler mice cotreated with CNTF and BDNF. Science. 265:1994;1107-1110.
13. Mitsumoto H., Ikeda K., Holmlund T., Greene T., Cedarbaum J., Wong V., Lindsay R.M. The effects of CNTF on motor dysfunction in wobbler mouse motor neuron disease. Ann. Neurol. 36:1994;142-148.
14. Oppenheim R.W., Yin Q.W., Prevette D., Yan Q. Brain-derived neurotrophic factor rescues developing avian motoneurons from cell death. Nature. 360:1992;755-757.
15. Sagot Y., Tan S.A., Hammang J.P., Aebischer P., Kato A.C. GDNF slows loss of motoneurons but not axonal degeneration or premature death of pmn/pmn mice. J. Neurosci. 16:1996;2335-2341.
16. Sendtner M.B., Kreutzberg G.W., Thoenen H. Ciliary neurotrophic factor prevents the degeneration of motor neurons after axotomy. Nature. 345:1990;440-441.
17. Sendtner M., Holtman B., Kolbeck R., Thoenen H., Barde Y. Brain-derived neurotrophic factor prevents the death of motoneurons in newborn rats after nerve section. Nature. 360:1992;757-759.
18. Swash M., Schwartz M. What do we really know about amyotrophic lateral sclerosis? J. Neurol. Sci. 113:1992;4-16.
19. Yan Q., Eliot J., Snider W.D. Brain-derived neurotrophic factor rescues spinal motoneurons from axotomy-induced cell death. Nature. 360:1992;753-755.