Endothelium-dependent vasodilation and tissue-type plasminogen activator release in borderline hypertension

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 17, Issue 12, 1997, Pages 3376-3383

  Jern, Sverker ^a   Wall, Ulrika ^a   Bergbrant, Anders ^a   Selin Sjögren, Lena ^a   Jern, Christina ^a  

^a SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Hypertension; Muscarinic receptors; PAI 1; TPA

Indexed keywords

METHACHOLINE; MUSCARINIC RECEPTOR; NITROPRUSSIDE SODIUM; TISSUE PLASMINOGEN ACTIVATOR;

ADULT; ARTICLE; ATHEROSCLEROSIS; BLOOD SAMPLING; CALCULATION; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE ASSOCIATION; ENDOTHELIUM CELL; HUMAN; HYPERCHOLESTEROLEMIA; HYPERTENSION; MALE; PLETHYSMOGRAPHY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SHEAR STRESS; SIGNAL TRANSDUCTION; VASODILATATION;

EID: 0031457662     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.ATV.17.12.3376     Document Type: Article

References (12)

1. Davies MG, Hagen P-O. The vascular endothelium: a new horizon. Ann Surg. 1993;218:593-609.
2. Emeis JJ. Mechanisms involved in short-term changes in blood levels of tissue-type plasminogen activator. In: Kluft C, ed. Tissue-Type Plasminogen Activator (t-PA): Physiological and Clinical Aspects. Boca Raton, Fla: CRC Press; 1988;2:21-35.
3. Furchgott RF, Zawadski JV. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature. 1980;288:373-376.
4. Vallance P, Collier J, Moncada S. Effects of endothelium-derived nitric oxide on peripheral arteriolar tone in man. Lancet. 1989;334: 997-1000.
5. Klöcking H-P. Release of plasminogen activator by acetylcholine from the isolated perfused pig ear. Thromb Res. 1979;16:261-264.
6. Nakajima K. Pharmacological observations of plasminogen activator release caused by vasoactive agents in isolated perfused pig ears. Thromb Res. 1983;29:163-174.
7. Emeis JJ. Perfused rat hindlegs: a model to study plasminogen activator release. Thromb Res. 1983;30:195-203.
8. Jern C, Selin L, Jern S. In vivo release of tissue-type plasminogen activator across the human forearm during mental stress. Thromb Haemost. 1994;72:285-291.
9. Jern C, Selin L, Jern S. Application of the perfused-forearm model to study release mechanisms of tissue-type plasminogen activator in man. Fibrinolysis. 1994;8(suppl 2):13-15.
10. Jern S, Selin L, Bergbrant A, Wall U, Jern C. Release of tissue-type plasminogen activator in response to muscarinic receptor stimulation in human forearm. Thromb Haemost. 1994;72:588-594.
11. Moncada S, Palmer RMJ, Higgs EA. Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol Rev. 1991;43: 109-142.
12. Panza JA, Quyyumi AA, Brush JJ, Epstein SE. Abnormal endothelium-dependent vascular relaxation in patients with essential hypertension. N Engl J Med. 1990;323:22-27.