Shear stress gradients remodel endothelial monolayers in vitro via a cell proliferation-migration-loss cycle

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 17, Issue 11, 1997, Pages 3102-3106

  Tardy, Y ^a,c   Resnick, N ^b   Nagel, T ^b   Gimbrone Jr , M A ^b   Dewey Jr , C F ^a  

^a Massachusetts Institute of Technology   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c EPFL   (Switzerland)

Author keywords

Artherosclerosis; Endothelium; Motility; Proliferation; Shear stress gradient

Indexed keywords

ARTICLE; ATHEROSCLEROSIS; BLOOD VESSEL WALL; CELL DIVISION; CELL LOSS; CELL MIGRATION; CELL PROLIFERATION; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; PRIORITY JOURNAL; SHEAR STRESS;

EID: 0031456799     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.ATV.17.11.3102     Document Type: Article

References (24)

1. Fry DL. Acute vascular endothelial changes associated with increased blood velocity gradients. Ore Res. 1968;22:165-197.
2. Dewey CF Jr, Bussolari SR, Gimbrone MA Jr, Davies PF. The dynamic response of vascular endothelial cells to fluid shear stress. J Biomech Eng. 1981;103:177-185.
3. Davies PF. How do vascular endothelial cells respond to flow? NIPS. 1989;4:22-25.
4. Fox JA, Hugh AE. Localization of atheroma: a theory based on boundary layer separation. Br Heart J. 1966;26:388-399.
5. Caro CG, Fitz-Gerald JM, Schroter RC. Atheroma and arterial wall shear: observation, correlation and proposal of a shear dependent mass transfer mechanism for atherogenesis. Proc R Soc Lond. 1969;177:109-159.
6. Zarins CK, Giddens DP, Bharadvaj BK, Sottiurai VS, Mabon RF, Glagov S. Carotid bifurcation atherosclerosis: quantitative correlation of plaque localization with flow velocity profiles and wall shear stress. Circ Res. 1983;53:502-514.
7. Ku DN, Giddens DP, Zarins CK, Glagov S. Pulsatile flow and atherosclerosis in the human carotid bifurcation. Arteriosclerosis. 1985;5:293-302.
8. Lutz RJ, Cannon JN, Bischoff KB, Dedrick RL, Stiles RK. Wall shear stress distribution in a model canine aorta during steady flow. Circ Res. 1977;41:391-399.
9. Langille BL, Reidy MA, Kline L. Injury and repair of endothelium at sites of flow disturbances near abdominal aortic coarctations in rabbits. Arteriosclerosis. 1986;6:146-154.
10. Levesque MJ, Liepsch D, Moravec S, Nerem RM. Correlation of endothelial cell shape and wall shear stress in a stenosed dog aorta. Arteriosclerosis. 1986;6:220-229.
11. Kim DW, Gotlieb AI, Languie BL. In vivo modulation of endothelial F-actin microfilaments by experimental alterations in shear stress. Arteriosclerosis. 1989;9:439-445.
12. Zand T, Majno G, Nunnari JJ, Hoffman AH, Savilonis BJ, MacWilliams B, Joris I. Lipid deposition and intimai stress and strain: a study in rats with aortic stenosis. Am J Pathol. 1991;139:101-113.
13. DePaola N, Gimbrone MA Jr, Davies PF, Forbes CF Jr. Vascular endothelium responds to fluid shear stress gradients. Arterio Thromb Vasc Biol. 1992;12:1254-1257.
14. Sdougos HP, Bussolari SR, Dewey CF Jr. Secondary flow and turbulence in a cone-and-plate device. J Fluid Mech. 1984;138:379-404.
15. Gimbrone MA Jr. Culture of vascular endothelium. In: Spaet T, ed. Progress in Hemostasis and Thrombosis. New York, NY: Grune & Stratton Inc, 1976:1-28.
16. Shen J, Luscinskas FW, Connolly A, Dewey CE Jr, Gimbrone MA Jr. Fluid shear stress modulates cytosolic free calcium in vascular endothelial cells. Am J Physiol. 1992;262:C384-C390.
17. Maday Y, Patera AT. Spectral element methods for the Navier-Stokes equations. In: Noor AK, Oden JT, eds. State-of-the-Art Surveys on Computational Mechanics. New York, NY: American Society of Mechanical Engineering, 1989:71-143.
18. Davies PF, Remuzzi A, Gordon EJ, Dewey CF Jr, Gimbrone MA Jr. Turbulent fluid shear stress induces vascular endothelial cell turnover in vitro. Proc Natl Acad Sci USA. 1986;83:2114-2117.
19. + current in vascular endothelial cells. Nature. 1988;331:168-170.
20. Davies PF. Flow-mediated endothelial mechanotransduction. Physiol Rev. 1995;75:519-560.
21. Davies PF, Mundel T, Barbee KA. A mechanism for heterogeneous endothelial responses to flow in vivo and in vitro. J Biomech. 1995;28:1553-60.
22. Caplan BA, Schwartz CJ. Increased endothelial cell turnover in areas of in vivo Evans Blue uptake in the pig aorta. Atherosclerosis. 1973;17:401-417.
23. Somer JB, Evans G, Schwartz CJ. Influence of experimental aortic coarctation on the pattern of aortic Evans blue uptake in vivo. Atherosclerosis. 1972;16:127-133.
24. Repin VS, Dolgov W, Zaikina OE, Novikov ID, Antonov AS, Nikolaeva MA, Smirnov VN. Heterogeneity of endothelium in human aorta: a quantitative analysis by scanning electron microscopy. Atherosclerosis. 1984;50:35-52.