Anti-interleukin (IL)-4 and -IL-5 antibodies downregulate IgE and eosinophilia in mice exposed to Aspergillus antigens

Allergy: European Journal of Allergy and Clinical Immunology

Volumn 52, Issue 12, 1997, Pages 1215-1221

  Kurup, V P ^a   Murali, P S ^a   Guo, J ^a   Choi, H ^a   Banerjee, B ^a   Fink, J N ^a   Coffman, R L ^b  

^a CLEMENT J ZABLOCKI VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Allergic aspergillosis; Anticytokine antibodies; Eosinophils; Lung histology

Indexed keywords

FUNGUS ANTIBODY; GAMMA INTERFERON; IMMUNOGLOBULIN E; INTERLEUKIN 4 ANTIBODY; INTERLEUKIN 5; MESSENGER RNA; MONOCLONAL ANTIBODY; PEROXIDASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPERGILLOSIS; ASPERGILLUS FUMIGATUS; BONE MARROW CELL; CONTROLLED STUDY; DOSE RESPONSE; DOWN REGULATION; EOSINOPHILIA; INTRAPERITONEAL DRUG ADMINISTRATION; LUNG; MOUSE; NONHUMAN; PRIORITY JOURNAL;

EID: 0031456652     PISSN: 01054538     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1398-9995.1997.tb02526.x     Document Type: Article

References (20)

1. Kurup VP, Mauze S, Choi H, Seymour BWP, Coffman RL. A murine model of allergic bronchopulmonary aspergillosis with elevated eosinophils and IgE. J Immunol 1992;148:3783-8.
2. Murali PS, Dai G, Kumar A, Fink JN, Kurup VP. Aspergillus antigen-induced eosinophil differentiation in a murine model. Infect Immun 1992;60:1952-6.
3. Murali PS, Kumar A, Choi H, Bansal NK, Fink JN, Kurup VP. Aspergillus fumigatus antigen induced eosinophilia in mice is abrogated by anti-IL-5 antibody. J Leukoc Biol 1993;53:264-7.
4. Kurup VP, Choi H, Murali PS, Coffman RL. IgE and eosinophil regulation in a murine model of allergic aspergillosis. J Leukoc Biol 1994;56:593-8.
5. Snapper CM, Finkelman FD, Paul WE. Differential regulation of IgG1 and IgE synthesis by interleukin 4. J Exp Med 1989;167:183-96.
6. de Vries JE, Punnonen J, Cocks BG, Aversa G. The role of T/B interactions and cytokines in the regulation of human IgE synthesis. Semin Immunol 1993;5:431-9.
7. Weller PF. Cytokine regulation of eosinophil function. Clin Immunol Immunopathol 1992;62:S55-9.
8. Kurup VR Fink JN, Scribner GH, Falk MJ. Antigenic variability of Aspergillus fumigatus strains. Microbios 1977;19:191-204.
9. Murali PS, Bamrah BS, Choi H, Fink JN, Kurup VP. Hyperimmune serum modulates allergic response to spores in a murine model of allergic aspergillosis. J Leukoc Biol 1994;55:29-34.
10. Kurup VP, Kumar A, Choi H, et al. Latex antigens induce IgE and eosinophils in mice. Int Arch Allergy Immunol 1994;103:370-7.
11. Coffman RL, Seymour BWP, Hudak S, Jackson J, Rennick D. Antibody to interleukin-5 inhibits helminth-induced eosinophilia in mice. Science 1989;245:308-10.
12. Sher A, Coffman RL, Heiny S, Scott P, Cheever AW. Interleukin 5 is required for the blood and tissue eosinophilia but not granuloma formation induced by infection with Schistosoma mansoni. Proc Natl Acad Sci USA 1990;87:61-5.
13. Hamann KJ, Gleich GJ. Eosinophil structure and function: roles in host defense and pathogenesis of disease. In: Sorged C, editor. Natural resistance to infection. New York, NY: Gustav-Fischer Verlag, 1990:60-88.
14. Kung TT, Jones H, Adams GK, et al. Characterization of a murine model of allergic pulmonary inflammation. Int Arch Allergy Immunol 1994;105:83-90.
15. Kuhn R, Rajewsky K, Muller W. Generation and analysis of interleukin-4 deficient mice. Science 1991;254:707-10.
16. Kopf M, Le Gros G, Bachmann M, Lamers MC, Bluethmann H, Kohler G. Disruption of the murine IL-4 gene blocks Th2 cytokine responses. Nature 1993;362: 245-8.
17. Lawrence RA, Allen JE, Gregory WF, Kopf M, Maizels RM. Infection of IL-4-deficient mice with the parasitic nematode Brugia malayi demonstrates that host resistance is not dependent on a T helper 2-dominated immune response. J Immunol 1995;154:5995-6001.
18. Finkelman FD, Katona IM, Urban JF, Snapper CM, O'Hara J, Paul WE. Suppression of in vivo polyclonal IgE responses by monoclonal antibody to the lymphokine B-cell stimulatory factor 1. Proc Natl Acad Sci USA 1986;83:9675-8.
19. + T cells in leishmaniasis. Immunol Today 1989;10:40-5.
20. + subsets during murine leishmania major infection. Res Immunol 1991;42:28-31.