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Volumn 123, Issue 11-12, 1997, Pages 623-631

Thiazolidinyl- and perhydrothiazinylphosphamidesters: Toxicity and preliminary antitumour evaluation

Author keywords

Antitumour activity; Thiazolidines and perhydrothiazines of aldophosphamide; Toxicity

Indexed keywords

ALDOPHOSPHAMIDE PERHYDROTHIAZINE; ALDOPHOSPHAMIDE THIAZOLIDINE; CYCLOPHOSPHAMIDE; OXAZAPHOSPHORINE DERIVATIVE; PHOSPHODIESTERASE; PHOSPHORAMIDE MUSTARD; UNCLASSIFIED DRUG;

EID: 0031456462     PISSN: 01715216     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004320050116     Document Type: Article
Times cited : (9)

References (33)
  • 1
    • 0020682197 scopus 로고
    • Enzymatic toxicogenation of "activated" cyclophosphamide by 3′-5′exonucleases
    • Bielicki L, Voelcker G, Hohorst HJ (1983) Enzymatic toxicogenation of "activated" cyclophosphamide by 3′-5′exonucleases. J Cancer Res Clin Oncol 105:27-29
    • (1983) J Cancer Res Clin Oncol , vol.105 , pp. 27-29
    • Bielicki, L.1    Voelcker, G.2    Hohorst, H.J.3
  • 2
    • 0021165938 scopus 로고
    • Activated cyclophosphamide: An enzyme-mechanism-based suicide inactivator of DNA polymerase/3′-5′ exonuclease
    • Bielicki L, Voelcker G, Hohorst HJ (1984) Activated cyclophosphamide: an enzyme-mechanism-based suicide inactivator of DNA polymerase/3′-5′ exonuclease. J Cancer Res Clin Oncol 107:195-198
    • (1984) J Cancer Res Clin Oncol , vol.107 , pp. 195-198
    • Bielicki, L.1    Voelcker, G.2    Hohorst, H.J.3
  • 3
    • 0017140119 scopus 로고
    • Comparative pharmacologic study in vitro and in vivo with cyclophosphamide (NSC 26271), cyclophosphamide metabolites, and plain nitrogen mustard compounds
    • Brock N (1976) Comparative pharmacologic study in vitro and in vivo with cyclophosphamide (NSC 26271), cyclophosphamide metabolites, and plain nitrogen mustard compounds. Cancer Treat Rep 60:301-308
    • (1976) Cancer Treat Rep , vol.60 , pp. 301-308
    • Brock, N.1
  • 4
    • 84961018230 scopus 로고
    • Über die Aktivierung von Cyclophosphamid in vivo und in vitro
    • Brock N, Hohorst HJ (1963) Über die Aktivierung von Cyclophosphamid in vivo und in vitro. Arzneimibtelforschung 13:1021-1031
    • (1963) Arzneimibtelforschung , vol.13 , pp. 1021-1031
    • Brock, N.1    Hohorst, H.J.2
  • 5
    • 0017346430 scopus 로고
    • The problem of specificity and selectivity of alkylating cytostatics: Studies on N-2-chloroethylamido-oxazaphosphorines
    • Brock N, Hohorst HJ (1977) The problem of specificity and selectivity of alkylating cytostatics: studies on N-2-chloroethylamido-oxazaphosphorines. Z Krebsforsch Klin Onkol 88:185-215
    • (1977) Z Krebsforsch Klin Onkol , vol.88 , pp. 185-215
    • Brock, N.1    Hohorst, H.J.2
  • 8
    • 0015968586 scopus 로고
    • Some studies of the active intermediate formed in the microsomal metabolism of cyclophosphamide and ifosphamide
    • Connors TA, Cox PJ, Farmer PB, Foster AB, Jarman M (1974) Some studies of the active intermediate formed in the microsomal metabolism of cyclophosphamide and ifosphamide. Biochem Pharmacol 23:115-129
    • (1974) Biochem Pharmacol , vol.23 , pp. 115-129
    • Connors, T.A.1    Cox, P.J.2    Farmer, P.B.3    Foster, A.B.4    Jarman, M.5
  • 10
    • 0017195724 scopus 로고
    • Deactivation of cyclophosphamide (NSC 26271) metabolites by sulfhydryl compounds
    • Draeger U, Peter G, Hohorst HJ (1976) Deactivation of cyclophosphamide (NSC 26271) metabolites by sulfhydryl compounds. Cancer Treat Rep 60:423-427
    • (1976) Cancer Treat Rep , vol.60 , pp. 423-427
    • Draeger, U.1    Peter, G.2    Hohorst, H.J.3
  • 11
    • 33947480040 scopus 로고
    • Colorimetric estimation of nitrogen mustards in aqueous media
    • Friedman OM, Boger E (1961) Colorimetric estimation of nitrogen mustards in aqueous media. Anal Chem 33:906-910
    • (1961) Anal Chem , vol.33 , pp. 906-910
    • Friedman, O.M.1    Boger, E.2
  • 12
    • 0014060675 scopus 로고
    • Determination of sulfhydryl groups with 2,2 and 4,4dithiodipyridine
    • Grasetti DR, Murray TF Jr (1967) Determination of sulfhydryl groups with 2,2 and 4,4dithiodipyridine. Arch Biochem Biophys 119:41-49
    • (1967) Arch Biochem Biophys , vol.119 , pp. 41-49
    • Grasetti, D.R.1    Murray Jr., T.F.2
  • 14
    • 0015105481 scopus 로고
    • 4-Ketocyclophosphamide a metabolite of cyclophosphamide. Formation, chemical and biological properties
    • Hohorst HJ, Ziemann A, Brock N (1971) 4-Ketocyclophosphamide a metabolite of cyclophosphamide. Formation, chemical and biological properties. Arzneimibtelforschung 21:1254-1257
    • (1971) Arzneimibtelforschung , vol.21 , pp. 1254-1257
    • Hohorst, H.J.1    Ziemann, A.2    Brock, N.3
  • 15
    • 0017182158 scopus 로고
    • The problem of oncostatic specificity of cyclophosphamide (NSC-2627 1): Studies on reactions that control the alkylating and cytotoxic activity
    • Hohorst HJ, Draeger U, Peter G, Voelcker G (1976) The problem of oncostatic specificity of cyclophosphamide (NSC-2627 1): studies on reactions that control the alkylating and cytotoxic activity. Cancer Treat Rep 60:309-315
    • (1976) Cancer Treat Rep , vol.60 , pp. 309-315
    • Hohorst, H.J.1    Draeger, U.2    Peter, G.3    Voelcker, G.4
  • 16
    • 0022999710 scopus 로고
    • The enzymatic basis of cyclophosphamide specificity
    • Hohorst HJ, Bielicki L, Voelcker G (1986) The enzymatic basis of cyclophosphamide specificity. Adv Enzyme Regul 25:99-122
    • (1986) Adv Enzyme Regul , vol.25 , pp. 99-122
    • Hohorst, H.J.1    Bielicki, L.2    Voelcker, G.3
  • 17
    • 0023909774 scopus 로고
    • Low toxicity cancer chemotherapy by suicide inactivation of DNA polymerase holoenzyme: First results with new thiazolidinyl- and perhydrothiazinyl-ethyl-N-mustard-phosphamide-esters
    • Hohorst HJ, Bielicki L, Müller K, Voelcker G (1988) Low toxicity cancer chemotherapy by suicide inactivation of DNA polymerase holoenzyme: first results with new thiazolidinyl- and perhydrothiazinyl-ethyl-N-mustard-phosphamide-esters, J Cancer Res Clin Oncol 114:309-311
    • (1988) J Cancer Res Clin Oncol , vol.114 , pp. 309-311
    • Hohorst, H.J.1    Bielicki, L.2    Müller, K.3    Voelcker, G.4
  • 18
    • 0026610907 scopus 로고
    • DNA polymerase ε: In search of a function
    • Hübscher U, Thömmes P (1992) DNA polymerase ε: in search of a function. Trends Biochem Sci 17:55-58
    • (1992) Trends Biochem Sci , vol.17 , pp. 55-58
    • Hübscher, U.1    Thömmes, P.2
  • 20
    • 15444340478 scopus 로고
    • Die Aufnahme von Taurin in Ehrlich Ascites Tumorzellen
    • Kromphardt H (1963) Die Aufnahme von Taurin in Ehrlich Ascites Tumorzellen. Biochem Z 339:233-254
    • (1963) Biochem Z , vol.339 , pp. 233-254
    • Kromphardt, H.1
  • 21
    • 0001063348 scopus 로고
    • The deoxyribonuclease of Escherichia coli. IV. An exonuclease activity present in purified preparations of deoxyribonucleic acid polymerase
    • Lehman IR, Richardson CC (1964) The deoxyribonuclease of Escherichia coli. IV. An exonuclease activity present in purified preparations of deoxyribonucleic acid polymerase. J Biol Chem 239:233-241
    • (1964) J Biol Chem , vol.239 , pp. 233-241
    • Lehman, I.R.1    Richardson, C.C.2
  • 22
    • 0018602558 scopus 로고
    • Synthesis and preliminary anti-tumor evaluation of 4(SR)-sulfido-cyclophosphamide
    • Peter G, Hohorst HJ (1979) Synthesis and preliminary anti-tumor evaluation of 4(SR)-sulfido-cyclophosphamide. Cancer Chemother Pharmacol 3:181-188
    • (1979) Cancer Chemother Pharmacol , vol.3 , pp. 181-188
    • Peter, G.1    Hohorst, H.J.2
  • 23
    • 0017152973 scopus 로고
    • Studies on 4-hydroperoxy-cyclophosphamide (NSC 181815): A simple preparation method and its application for the synthesis of a new class of "activated" sulfur-containing cyclophosphamide (NSC 26271) derivatives
    • Peter G, Wagner T, Hohorst HJ (1976) Studies on 4-hydroperoxy-cyclophosphamide (NSC 181815): a simple preparation method and its application for the synthesis of a new class of "activated" sulfur-containing cyclophosphamide (NSC 26271) derivatives. Cancer Treat Rep 60:429-435
    • (1976) Cancer Treat Rep , vol.60 , pp. 429-435
    • Peter, G.1    Wagner, T.2    Hohorst, H.J.3
  • 24
    • 0015308178 scopus 로고
    • Therapeutic efficacy of cyclophosphamide as a function of its metabolism
    • Sladek NE (1972) Therapeutic efficacy of cyclophosphamide as a function of its metabolism. Cancer Res 32:535-542
    • (1972) Cancer Res , vol.32 , pp. 535-542
    • Sladek, N.E.1
  • 25
    • 0015607955 scopus 로고
    • Evidence for an aldehyde possessing alkylating activity as the primary metabolite of cyclophosphamide
    • Sladek NE (1973a) Evidence for an aldehyde possessing alkylating activity as the primary metabolite of cyclophosphamide. Cancer Res 33:651-658
    • (1973) Cancer Res , vol.33 , pp. 651-658
    • Sladek, N.E.1
  • 26
    • 0015786178 scopus 로고
    • Bioassay and relative cytotoxic potency of cyclophosphamide metabolites generated in vitro and in vivo
    • Sladek NE (1973b) Bioassay and relative cytotoxic potency of cyclophosphamide metabolites generated in vitro and in vivo. Cancer Res 33:1150-1159
    • (1973) Cancer Res , vol.33 , pp. 1150-1159
    • Sladek, N.E.1
  • 27
    • 0017115562 scopus 로고
    • Identification and pharmacokinetics of cyclophosphamide (NSC 26271) metabolites in vivo
    • Voelcker G, Wagner T, Hohorst HJ (1976) Identification and pharmacokinetics of cyclophosphamide (NSC 26271) metabolites in vivo. Cancer Treat Reps, 60:415-422
    • (1976) Cancer Treat Reps , vol.60 , pp. 415-422
    • Voelcker, G.1    Wagner, T.2    Hohorst, H.J.3
  • 29
    • 0018339832 scopus 로고
    • Die intravenöse Injektion über den retrobulbären Plexus bei der Maus
    • Voelcker G, Fortmeyer HP (1979) Die intravenöse Injektion über den retrobulbären Plexus bei der Maus. Z Versuchtierkd 21:177-181
    • (1979) Z Versuchtierkd , vol.21 , pp. 177-181
    • Voelcker, G.1    Fortmeyer, H.P.2
  • 30
    • 0018788608 scopus 로고
    • Fluorometrische Bestimmung von "aktiviertem" Cyclophosphamid und Ifosfamid im Blut
    • Voelcker G, Haeglsperger R, Hohorst HJ (1979) Fluorometrische Bestimmung von "aktiviertem" Cyclophosphamid und Ifosfamid im Blut. J Cancer Res Clin Oncol 93:233-240
    • (1979) J Cancer Res Clin Oncol , vol.93 , pp. 233-240
    • Voelcker, G.1    Haeglsperger, R.2    Hohorst, H.J.3
  • 31
    • 0019423750 scopus 로고
    • Evidence for enzymatic toxification of "activated" cyclophosphamide (4-hydroxycyclophosphamide)
    • Voelcker G, Bielicki L, Hohorst HJ (1981) Evidence for enzymatic toxification of "activated" cyclophosphamide (4-hydroxycyclophosphamide) J Cancer Res Clin Oncol 99A:58-59
    • (1981) J Cancer Res Clin Oncol , vol.99 A , pp. 58-59
    • Voelcker, G.1    Bielicki, L.2    Hohorst, H.J.3
  • 33
    • 0018923129 scopus 로고
    • Butspiegel und Urin-Ausscheidung von aktiviertem Cyclophosphamid und seinen Deaktivierungsprodukten beim Menschen
    • Wagner T, Heydrich D, Voelcker G, Hohorst HJ (1980) Butspiegel und Urin-Ausscheidung von aktiviertem Cyclophosphamid und seinen Deaktivierungsprodukten beim Menschen. J Cancer Res Clin Oncol 96:79-92
    • (1980) J Cancer Res Clin Oncol , vol.96 , pp. 79-92
    • Wagner, T.1    Heydrich, D.2    Voelcker, G.3    Hohorst, H.J.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.