Formation of cytomegalovirus DNA replication compartments defined by localization of viral proteins and DNA synthesis

Virology

Volumn 239, Issue 1, 1997, Pages 46-61

  Penfold, Mark E T ^a   Mocarski, Edward S ^a  

^a STANFORD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BROXURIDINE; DNA BINDING PROTEIN; DNA POLYMERASE; FOSCARNET; GANCICLOVIR; GENE PRODUCT; SINGLE STRANDED DNA; URACIL DNA GLYCOSYLTRANSFERASE; VIRUS DNA; VIRUS PROTEIN;

ARTICLE; CELL COMPARTMENTALIZATION; CONTROLLED STUDY; CYTOMEGALOVIRUS INFECTION; DNA REPLICATION; DNA SYNTHESIS; FIBROBLAST; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN LOCALIZATION; VIRUS MUTANT; VIRUS REPLICATION;

ANIMALIA; CUCUMBER MOSAIC VIRUS; CYTOMEGALOVIRUS; DNA VIRUSES; HUMAN HERPESVIRUS 5;

EID: 0031455909     PISSN: 00426822     EISSN: None     Source Type: Journal    
DOI: 10.1006/viro.1997.8848     Document Type: Article

References (71)

1. Ahn J. H., Hayward G. S. The major immediate-early proteins IE1 and IE2 of human cytomegalovirus colocalize with and disrupt PML-associated nuclear bodies at very early times in infected permissive cells. J. Virol. 71:1997;4599-4613.
2. Albrecht T., Boldogh I., Fons M., Lee C. H., AbuBakar S., Russell J. M., Au W. W. Cell-activated responses to cytomegalovirus infection: Relationship to the phasing of CMV replication and to the induction of cellular damage. Subcell. Biochem. 15:1989;157-202.
3. Alford C. A., Britt W. J. Cytomegalovirus. Fields Virology. 1995;Lippincott-Raven, New York. p. 2493-2534.
4. Boehmer P. E., Lehman I. R. Herpes simplex virus DNA replication. Annu. Rev. Biochem. 66:1997;347-384.
5. Boldogh I., Gonczol E., Gartner L., Vaczi L. Stimulation of host DNA synthesis and induction of early antigens by ultraviolet light irradiated human cytomegalovirus. Arch. Virol. 58:1978;289-299.
6. Bravo R., Frank R., Blundell P. A., Macdonald-Bravo H. Cyclin/PCNA is the auxilary protein of DNA polymerase delta. Nature. 326:1987;515-517.
7. Bresnahan W. A., Boldogh I., Thompson E. A., Albrecht T. Human cytomegalovirus inhibits cellular DNA synthesis and arrests productively infected cells in late G1. Virology. 224:1996;150-160.
8. Bush M., Yager D. R., Gao M., Weisshart K., Marcy A. I., Coen D. M., Knipe D. M. Correct intranuclear localization of herpes simplex virus DNA polymerase requires the viral ICP8 DNA-binding protein. J. Virol. 65:1991;1082-1089.
9. Cha T. A., Tom E., Kemble G. W., Duke G. M., Mocarski E. S., Spaete R. R. Human cytomegalovirus clinical isolates carry at least 19 genes not found in laboratory strains. J. Virol. 70:1996;78-83.
10. Chee M. S., Bankier A. T., Beck S., Bohni R., Brown C. M., Cerny R., Horsnell T., Hutchison C. A. I., Kouzarides T., Martignetti J. A., Preddie E., Satchwell S. C., Tomlinson P., Weston K. M., Barrell B. G. Analysis of the protein-coding content of the sequence of human cytomegalovirus strain AD169. Curr. Top. Microbiol. Immunol. 154:1990;125-170.
11. Colberg-Poley A. M., Santomenna L. D., Harlow P. P., Benfield P. A., Tenney D. J. Human cytomegalovirus US3 and UL36-38 immediate-early proteins regulate gene expression. J. Virol. 66:1992;95-105.
12. de Bruyn Kops A., Knipe D. M. Formation of DNA replication structures in herpes virus-infected cells requires a viral DNA binding protein. Cell. 55:1988;857-868.
13. de Bruyn Kops A., Knipe D. M. Preexisting nuclear architecture defines the intranuclear location of herpesvirus DNA replication structures. J. Virol. 68:1994;3512-3526.
14. DeMarchi J. M. Correlation between stimulation of host cell DNA synthesis by human cytomegalovirus and lack of expression of a subset of early virus genes. Virology. 129:1983;274-286.
15. DeMarchi J. M., Kaplan A. S. Replication of human cytomegalovirus DNA: Lack of dependence on cell DNA synthesis. J. Virol. 18:1976;1063-1070.
16. Dittmer D., Mocarski E. S. Human cytomegalovirus infection inhibits G1/S transition. J. Virol. 71:1997;1629-1634.
17. Ertl P. F., Powell K. L. Physical and functional interaction of human cytomegalovirus DNA polymerase and its accessory protein (ICP36) expressed in insect cells. J. Virol. 66:1992;4126-4133.
18. Ertl P. F., Thomas M. S., Powell K. L. High level expression of DNA polymerases from herpesviruses. J. Gen. Virol. 72:1991;1729-1734.
19. Everett R. D., Maul G. G. HSV-1 IE protein Vmw110 causes redistribution of PML. EMBO J. 13:1994;5062-5069.
20. Fons M. P., Graves K., Cavallo T., Pollard R., Albrecht T. Human cytomegalovirus: Development and progression of nuclear inclusions by primary clinical isolates and laboratory-adapted strains. Proc. Soc. Exp. Biol. Med. 181:1986;416-422.
21. Furukawa T., Sakuma S., Plotkin S. A. Human cytomegalovirus infection of WI-38 cells stimulates mitochondrial DNA synthesis. Nature. 262:1976;414-416.
22. Furukawa T., Tanaka S., Plotkin S. A. Stimulation of macromolecular synethesis in guinea pig cells by human CMV. Proc. Soc. Exp. Biol. Med. 148:1975;211-214.
23. Greaves R. F., Mocarski E. S. Defective growth correlates with reduced accumulation of a viral DNA replication protein after low multiplicity infection by a human cytomegalovirusie1. J. Virol. 1997.
24. Ihara S., Saito S., Watanabe Y. Human cytomegalovirus-induced inhibition of exogenous thymidine uptake into cell DNA in HEL cells stimulated to proliferate with serum. Tokai J. Exp. Clin. Med. 5:1980;301-309.
25. Ishov A. M., Maul G. G. The periphery of nuclear domain 10 (ND10) as site of DNA virus deposition. J. Cell Biol. 134:1996;815-826.
26. Ishov A M., Stenberg R. M., Maul G. G. Human cytomegalovirus immediate early interaction with host nuclear structures: Definition of an immediate early transcript environment. J. Cell Biol. 138:1997;5-16.
27. Iskenderian A. C., Huang L., Reilly A., Stenberg R. M., Anders D. G. Four of eleven loci required for transient complementation of human cytomegalovirus DNA replication cooperate to activate expression of replication genes. J. Virol. 70:1996;383-392.
28. Iwayama S., Yamamoto T., Furuya T., Kobayashi R., Ikuta K., Hirai K. Intracellular localization and DNA-binding activity of a class of viral early phosphoproteins in human fibroblasts infected with human cytomegalovirus (Towne strain). J. Gen. Virol. 75:1994;3309-3318.
29. Jault F. M., Jault J. M., Ruchti F., Fortunato E. A., Clark C., Corbeil J., Richman D. D., Spector D. H. Cytomegalovirus infection induces high levels of cyclins, phosphorylated Rb, and p53, leading to cell cycle arrest. J. Virol. 69:1995;6697-6704.
30. Kanich R. E., Craighead J. E. Human cytomegalovirus infection of cultured fibroblasts. II. Viral replicative sequence of a wild and an adapted strain. Lab. Invest. 27:1972;273-282.
31. Kemble G. W., McCormick A. L., Pereira L., Mocarski E. S. A cytomegalovirus protein with properties of herpes simplex virus ICP8: Partial purification of the polypeptide and map position of the gene. J. Virol. 61:1987;3143-3151.
32. Kerry J. A., Priddy M. A., Jervey T. Y., Kohler C. P., Staley T. L., Vanson C. D., Jones T. R., Iskenderian A. C., Anders D. G., Stenberg R. M. Multiple regulatory events influence human cytomegalovirus DNA polymerase (UL54) expression during viral infection. J. Virol. 70:1996;373-382.
33. LaFemina R. L., Pizzorno M. C., Mosca J. D., Hayward G. S. Expression of the acidic nuclear immediate-early protein (IE1) of human cytomegalovirus in stable cell lines and its preferential association with metaphase chromosomes. Virology. 172:1989;584-600.
34. Lee S. H., Pan Z. Q., Kwong A. D., Burgers P. M., Hurwitz J. Synthesis of DNA by DNA polymerase epsilon in vitro. J. Biol. Chem. 266:1991;22707-22717.
35. Liptak L. M., Uprichard S. L., Knipe D. M. Functional order of assembly of herpes simplex virus DNA replication proteins into prereplicative site structures. J. Virol. 70:1996;1759-1767.
36. 1. J. Virol. 70:1996;8850-8857.
37. Lukonis C. J., Burkham J., Weller S. K. Herpes simplex virus type 1 prereplicative sites are a heterogeneous population: Only a subset are likely to be precursors to replication compartments. J. Virol. 71:1997;4771-4781.
38. Lukonis C. J., Weller S. K. Characterization of nuclear structures in cells infected with herpes simplex virus type 1 in the absence of viral DNA replication. J. Virol. 70:1996;1751-1758.
39. McAllister R. M., Filbert J. E., Goodheart C. R. Human cytomegalovirus. Studies on the mechanism of viral cytopathology and inclusion body formation. Proc. Soc. Exp. Biol. Med. 124:1967;932-937.
40. Mocarski E. S. Cytomegaloviruses and their replication. Third ed. Fields B. N., Knipe D. M., Howley P. M. Fields Virology. 1995;2447-2492 Lippincott-Raven, New York.
41. Mocarski E. S., Kemble G. W., Lyle J. M., Greaves R. F. A deletion mutant in the human cytomegalovirus gene encoding IE1(491aa) is replication defective due to a failure in autoregulation. Proc. Natl. Acad. Sci. USA. 93:1996;11321-11326.
42. Mocarski E. S., Pereira L., Michael N. Precise localization of genes on large animal virus genomes: Use of lambda gt11 and monoclonal antibodies to map the gene for a cytomegalovirus protein family. Proc. Natl. Acad. Sci. USA. 82:1985;1266-1270.
43. Morin J., Johann S., O'Hara B., Gluzman Y. Exogenous thymidine is preferentially incorporated into human cytomegalovirus DNA in infected human fibroblasts. J. Virol. 70:1996;6402-6404.
44. Otto S. M., Sullivan T. G., Malone C. L., Stinski M. F. Subcellular localization of the major immediate early protein (IE1) of human cytomegalovirus at early times after infection. Virology. 162:1988;478-482.
45. Pari G. S., Anders D. G. Eleven loci encoding trans-acting factors are required for transient complementation of human cytomegalovirus oriLyt-dependent DNA replication. J. Virol. 67:1993;6979-6988.
46. Pari G. S., Kacica M. A., Anders D. G. Open reading frames UL44, IRS1/TRS1, and UL36-38 are required for transient complementation of human cytomegalovirus oriLyt-dependent DNA synthesis. J. Virol. 67:1993;2575-2582.
47. Penfold M. E., Armati P., Cunningham A. L. Axonal transport of herpes simplex virions to epidermal cells: Evidence for a specialized mode of virus transport and assembly. Proc. Natl. Acad. Sci. USA. 91:1994;6529-6533.
48. Pereira L., Hoffman M., Gallo D., Cremer N. Monoclonal antibodies to human cytomegalovirus: Three surface membrane proteins with unique immunological and electrophoretic properties specify cross-reactive determinants. Infect. Immun. 36:1982;924-932.
49. Plachter B., Britt W., Vornhagen R., Stamminger T., Jahn G. Analysis of proteins encoded by IE regions 1 and 2 of human cytomegalovirus using monoclonal antibodies generated against recombinant antigens. Virology. 193:1993;642-652.
50. Plachter B., Nordin M., Wirgart B. Z., Mach M., Stein H., Grillner L., Jahn G. The DNA-binding protein P52 of human cytomegalovirus reacts with monoclonal antibody CCH2 and associates with the nuclear membrane at late times after infection. Virus Res. 24:1992;265-276.
51. Prichard M. N., Duke G. M., Mocarski E. S. Human cytomegalovirus uracil DNA glycosylase is required for the normal temporal regulation of both DNA synthesis and viral replication. J. Virol. 70:1996;3018-3025.
52. Quinlan M. P., Chen L. B., Knipe D. M. The intranuclear location of a herpes simplex virus DNA-binding protein is determined by the status of viral DNA replication. Cell. 36:1984;857-868.
53. Rixon F. J., Atkinson M. A., Hay J. Intranuclear distribution of herpes simplex virus type 2 DNA synthesis: Examination by light and electron microscopy. J. Gen. Virol. 64:1983;2087-2092.
54. Sarisky R. T., Hayward G. S. Evidence that the UL84 gene product of human cytomegalovirus is essential for promoting oriLyt-dependent DNA replication and formation of replication compartments in cotransfection assays. J. Virol. 70:1996;7398-7413.
55. Severi B., Landini M. P., Cenacchi G., Zini N., Maraldi N. M. Human cytomegalovirus nuclear and cytoplasmic dense bodies. Arch. Virol. 123:1992;193-207.
56. Smith J. A., Jairath S., Crute J. J., Pari G. S. Characterization of the human cytomegalovirus UL105 gene and identification of the putative helicase protein. Virology. 220:1996;251-255.
57. Smith J. A., Pari G. S. Expression of human cytomegalovirus UL36 and UL37 genes is required for viral DNA replication. J. Virol. 69:1995a;1925-1931.
58. Smith J. A., Pari G. S. Human cytomegalovirus UL102 gene. J. Virol. 69:1995b;1734-1740.
59. Spaete R. R., Mocarski E. S. Regulation of cytomegalovirus gene expression: α and β promoters are trans activated by viral functions in permissive human fibroblasts. J. Virol. 56:1985;135-143.
60. Spector D. J., Tevethia M. J. Protein-protein interactions between human cytomegalovirus IE2-580aa and pUL84 in lytically infected cells. J. Virol. 68:1994;7549-7553.
61. St Jeor S., Hutt R. Cell DNA replication as a function in the synthesis of human cytomegalovirus. J. Gen. Virol. 37:1977;65-73.
62. St Jeor S. C., Albrecht T. B., Funk F. D., Rapp F. Stimulation of cellular DNA synthesis by human cytomegalovirus. J. Virol. 13:1974;353-362.
63. R. M. Stenberg, 1993, Immediate-early genes of human cytomegalovirus: Organization and function, Molecular Aspects of Human Cytomegalovirus Diseases, E. S. Huang, 330, 359, Springer-Verlag, Heidelberg.
64. Tenney D. J., Colberg-Poley A. M. Expression of the human cytomegalovirus UL36-38 immediate early region during permissive infection. Virology. 182:1991;199-210.
65. Uprichard S. L., Knipe D. M. Assembly of herpes simplex virus replication proteins at two distinct intranuclear sites. Virology. 229:1997;113-125.
66. Valnes K., Brandtzaeg P. Retardation of immunofluorescence fading during microscopy. J. Histochem. Cytochem. 33:1985;755-761.
67. Ward P. L., Ogle W. O., Roizman B. Assemblons: Nuclear structures defined by aggregation of immature capsids and some tegument proteins of herpes simplex virus 1. J. Virol. 70:1996;4623-4631.
68. Wilcock D., Lane D. P. Localization of p53, retinoblastoma and host replication proteins at sites of viral replication in herpes-infected cells. Nature. 349:1991;429-431.
69. Winkler M., Rice S. A., Stamminger T. UL69 of human cytomegalovirus, an open reading frame with homology to ICP27 of herpes simplex virus, encodes a transactivator of gene expression. J. Virol. 68:1994;3943-3954.
70. Wolber R. A., Beals T. F., Lloyd R. V., Maassab H. F. Ultrastructural localization of viral nucleic acid by in situ hybridization. Lab. Invest. 59:1988;144-151.
71. Wright D. A., Staprans S. I., Spector D. H. Four phosphoproteins with common amino termini are encoded by human cytomegalovirus AD169. J. Virol. 62:1988;331-340.