Neuropeptide Y inhibits chromaffin cell nicotinic receptorstimulated tyrosine hydroxylase activity through a receptorlinked G protein-mediated process

Molecular Pharmacology

Volumn 52, Issue 6, 1997, Pages 1027-1033

  Zheng, Jialin ^a   Zhang, Peijin ^a   Hexum, Terry D ^a  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINE; NEUROPEPTIDE Y; NICOTINIC RECEPTOR; TYROSINE 3 MONOOXYGENASE;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CALCIUM TRANSPORT; CATECHOLAMINE RELEASE; CHROMAFFIN CELL; CONCENTRATION RESPONSE; CULTURE MEDIUM; DRUG EFFECT; DRUG POTENCY; ENZYME ACTIVITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RECEPTOR UPREGULATION; SECOND MESSENGER;

EID: 0031455195     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.52.6.1027     Document Type: Article

References (40)

1. Wahlestedt, C., and D. J. Reis. Neuropeptide Y-related peptides and their receptors-are the receptors potential therapeutic drug targets? Annu. Rev. Pharmacol. Toxicol. 33:309-352 (1993).
2. Eva, C., K. Keinanen, H. Monyer, P. Seeburg, and R. Sprengel. Molecular cloning of a novel G protein-coupled receptor that may belong to the neuropeptide receptor family. FEBS Lett. 271:81-84 (1990).
3. Rose, P. M., P. Fernandes, J. S. Lynch, S. T. Frazier, S. M. Fisher, K. Kodukula, B. Kienzle, and R. Seethala. Cloning and functional expression of a cDNA encoding a human type 2 neuropeptide Y receptor. J. Biol. Chem. 270:22661-22664 (1995).
4. Gerald, C., M. W. Walker, P. J. J. Vaysse, C. G. He, T. A. Branchek, and R. L. Weinshank. Expression cloning and pharmacological characterization of a human hippocampal neuropeptide Y peptide YY Y2 receptor subtype. J. Biol. Chem. 270:26758-26761 (1995).
5. Bard, J.A., M. W. Walker, T. A. Branchek, and R. L. Weinshank. Cloning and functional expression of a human Y4 subtype receptor for Pancreatic polypeptide, neuropeptide Y, and peptide YY. J. Biol. Chem. 270:26762-26765 (1995).
6. Lundell, I., A. G. Blomqvist, M. M. Berglund, D. A. Schober, D. Johnson, M. A. Statnick, R. A. Gadski, D. R. Gehlert, and D. Larhammar. Cloning of a human receptor of the NPY receptor family with high affinity for pancreatic polypeptide and peptide YY. J. Biol. Chem. 270:29123-29128 (1995).
7. Gerald, C., M. W. Walker, L. Criscione, E. L. Gustafson, C. Batzl-Hartmann, K. E. Smith, P. Vaysse, M. M. Durkin, T. M. Laz, D. L. Linemeyer, A. O. Schaffhauser, S. Whitebread, K. G. Hofbauer, R. I. Taber, T. A. Branchek, and R. L. Weinshank. A receptor subtype involved in neuropeptide-Y-induced food intake. Nature (Lond.) 382:168-171 (1996).
8. Michel, M. C. Receptors for neuropeptide Y: multiple subtypes and multiple second messengers. Trends Pharmacol. Sci. 12:389-394 (1991).
9. Majane, E. A., H. Alho, Y. Kataoka, C. H. Lee, and H.-Y. T. Yang. Neuropeptide Y in bovine adrenal glands: distribution and characterization. Endocrinology 117:1162-1168 (1985).
10. Lundberg, J. M., G. Fried, J. Pernow, and E. Theodorsson-Norheim. Co-release of neuropeptide Y and catecholamines upon adrenal activation in the Cat. Acta Physiol. Scand. 126:231-238 (1986).
11. Hexum, T. D., E. A. Majane, L. R. Russett, and H.-Y. T. Yang. Neuropeptide Y release from the adrenal medulla after cholinergic receptor stimulation. J. Pharmacol. Exp. Ther. 243:927-930 (1987).
12. Kataoka, Y., E. A. Majane, and H.-Y. T. Yang. Release of NPY-like immunoreactive material from primary cultures of chromaffin cells prepared from bovine adrenal medulla. Neuropharmacology 24:693-695 (1985).
13. Hexum, T. D., J. Zheng, and J. Zhu. Neuropeptide Y inhibition of nicotinic receptor-mediated chromaffin cell secretion. J. Pharmacol. Exp. Ther. 271:61-66 (1994).
14. Zhu, J., W. Li, M. L. Toews, and T. D. Hexum. Neuropeptide Y inhibits forskolin-stimulated adenylate cyclase in bovine adrenal chromaffin cells via a pertussis toxin-sensitive process. J. Pharmacol. Exp. Ther. 263: 1479-1486 (1992).
15. Higuchi, H., E. Costa, and Y. H. Yang. Neuropeptide Y inhibits the nicotine-mediated release of catecholamines from bovine adrenal chromaffin cells. J. Pharmacol. Exp. Ther. 244:468-474 (1988).
16. Zheng, J., R. A. Morrisett, J. Zhu, and T. D. Hexum. Neuropeptide Y (18-36) modulates chromaffin cell catecholamine secretion by blocking the nicotinic receptor ion channel. J. Pharmacol. Exp. Ther. 274:891-897 (1995).
17. Zigmond, R. E., M. A. Schwarzschild, and A. R. Rittenhouse. Acute regulation of tyrosine hydroxylase by nerve activity and by neurotransmitters via phosphorylation. Annu. Rev. Neurosci. 12:415-461 (1989).
18. Cheng, J.-T., C.-L. Chang, and C.-L. Tsai. Inhibitory effect of neuropeptide Y (NPY) on the in vitro activity of tyrosine hydroxylase. Neurosci. Lett. 167:117-120 (1994).
19. McCullough, L. A., and T. C. Westfall. Neuropeptide Y inhibits depolarization-stimulated catecholamine synthesis in rat pheochromocytoma cells. Eur. J. Pharmacol. 287:271-277 (1995).
20. Weiner, N. Regulation of norepinephrine biosynthesis. Annu. Rev. Pharmacol. 10:273-290 (1970).
21. Pocotte, S. L. R. W. Holz, and T. Ueda. Cholinergic receptor-mediated phosphorylation and activation of tyrosine hydroxylase in cultured bovine adrenal chromaffin cells. J. Neurochem. 46:610-622 (1986).
22. Hexum, T. D., and L. R. Russett. Stimulation of cholinergic receptor-mediated secretion from the bovine adrenal medulla by neuropeptide Y. Neuropeptides 13:25-41 (1988).
23. Waymire, J. C., G. L. Craviso, K. Lichteig, J. P. Johnston, C. Baldwin, and R. E. Zigmond. Vasoactive intestinal peptide stimulates catecholamine biosynthesis in isolated adrenal chromaffin cells: evidence for a cyclic AMP-dependent phos. J. Neurochem. 57:1313-1324 (1991).
24. Laemmli, U. K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (Lond.) 227:680-685 (1970).
25. Haycock, J. W., M. D. Browning, and P. Greengard. Cholinergic regulation of protein phosphorylation in bovine adrenal chromaffin cells. Proc. Natl. Acad. Sci. USA 85:1677-1681 (1988).
26. Noerenberg, W., P. Illes, and K. Takeda. Neuropeptide Y inhibits nicotinic cholinergic currents but not voltage-dependent calcium currents in bovine chromaffin cells. Pfluegers Arch. 418:346-352 (1991).
27. Grundemar, L. Multiple receptors and multiple actions, in Neuropeptide Y and Drug Development (L. Grundemar and S. R. Bloom, eds.). Academic Press, San Diego, CA, 1-14 (1997).
28. 2+ channel currents in cultured bovine adrenal chromaffin cells. Neuron 16:1027-1036 (1996).
29. Wahlestedt, C., S. Regunathan, and D. J. Reis. Identification of cultured cells selectively expressing Y1-, Y2-, or Y3-type receptors for neuropeptide Y/peptide YY. Life Sci. 50:PL7-PL12 (1992).
30. Haycock, J. W. Phosphorylation of tyrosine hydroxylase in situ at serine 8, 19, 31, and 40. J. Biol. Chem. 265:11682-11691 (1990).
31. 2+ currents in rat sensory neurons. J. Neurosci. 8:2438-2446 (1988).
32. Hirning, L. D., A. P. Fox, and R. J. Miller. Inhibition of calcium currents in cultured myenteric neurons by neuropeptide Y: evidence for direct receptor/channel coupling. Brain. Res. 532:120-130 (1990).
33. Haycock, J. W., N. G. Ahn, M. H. Cobb, and E. G. Krebs. ERK1 and ERK2, two microtubule-associated protein 2 kinases, mediate the phosphorylation of tyrosine hydroxylase at serine-31 in situ. Proc. Natl. Acad. Sci. USA 89:2365-2369 (1992).
34. 40. Neurochem. Res. 18:15-26 (1993).
35. Anderson, K., P. J. Robinson, and P. D. Marley. Cholinoceptor regulation of cyclic AMP levels in bovine adrenal medullary cells. Br. J. Pharmacol. 106:360-366 (1992).
36. Brown, N. A., G. McAllister, D. Weinberg, G. Milligan, and G. R. Seabrook. Involvement of G-protein αi1 subunits in activation of G-protein gated inward rectifying K+ channels (GIRK1) by human NPY1 receptors. Br. J. Pharmacol. 116:2346-2348 (1995).
37. Inoue, M., and I. Imanaga. Phosphorylation-dependent regulation of non-selective cation channels in guinea pig chromaffin cells. Am. J. Physiol. 265:C343-C348 (1993).
38. Goldstein, M., K. Y. Lee, J. Y. Lew, K. Harada, J. Wu, J. W. Haycock, T. Hokfelt, and A. Y. Deutch. Antibodies to a segment of tyrosine hydroxylase phosphorylated at serine 40. J. Neurochem. 64:2281-2287 (1995).
39. Schwartz, J. H. Synaptic vesicles, in Priniciples of Neural Science (Kandel, E. R., J. H. Schwartz, and T. M. Jessell, eds.). Ed. 3. Appleton & Lange, Norwalk, CT, 225-234 (1991).
40. Lundberg, J. M., and T. Hokfelt. Coexistence of peptides and classical neurotransmitters. Trends. Neuro. Sci. 6:325-333 (1983).