Liver lectin blocking with D-galactose to prevent hepatic metastases in colorectal carcinoma patients

Anticancer Research

Volumn 17, Issue 5 B, 1997, Pages 3767-3772

  Isenberg, J ^a,e   Stoffel, B ^b   Stutzer H ^c   Otte K ^d   Beuth, J ^b  

^a Clinics and Policlinics for Surgery

^b Inst Med Microbiol and Hygienics

^c Inst Med Stat Info Epidemiol   (Germany)

^d UNIVERSITY OF COLOGNE   (Germany)

^e Malteser Krankenhaus   (Germany)

Author keywords

Colorectal carcinoma; D galactose; Liver metastases

Indexed keywords

GALACTOSE; GLUCOSE; LECTIN;

ADULT; AGED; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER RECURRENCE; CANCER SURGERY; CANCER SURVIVAL; CLINICAL TRIAL; COLORECTAL CARCINOMA; CONTROLLED STUDY; DRUG INFUSION; FEMALE; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; LIVER METASTASIS; MAJOR CLINICAL STUDY; MALE; MORTALITY; MOUSE; NONHUMAN; POSTOPERATIVE COMPLICATION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RECEPTOR BLOCKING;

ADULT; AGED; AGED, 80 AND OVER; ANIMALS; COLONIC NEOPLASMS; DISEASE-FREE SURVIVAL; FEMALE; GALACTOSE; HUMANS; LECTINS; LIVER; LIVER NEOPLASMS; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED DBA; MIDDLE AGED; NEOPLASM RECURRENCE, LOCAL; NEOPLASM STAGING; PROSPECTIVE STUDIES; RECTAL NEOPLASMS;

EID: 0031454679     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (18)

1. Olson RM, Perencevich NP, Malcolm AW, et al: Patterns of recurrence following curative resection of adenocarcinoma of the colon and rectum. Cancer 48: 2969-2974, 1980.
2. Adson MA, van Heerden JA, Adson MH, et al: Resection of hepatic metastases from colorectal cancer. Arch Surg 119: 647-651, 1984.
3. Scheele J, Stangl R, Altendorf-Hofmann A: Hepatic metastases from colorectal carcinoma: impact of surgical resection on the natural history. Br J Sur 77: 1241-1246, 1990.
4. Isenberg J, Fischbach R, Krüger I, Keller HW: Treatment of liver metastases from colorectal cancer. Anticancer Res 16: 1291-1296, 1996.
5. Cole WH and Hymphrey L: Need for immunologic stimulators during immunosuppression produced by major cancer surgery. Ann Surg 22: 9-20, 1985.
6. Griffiths JD, McKinna JA, Rowbothan HD et al: Carcinoma of the colon and rectum: circulating malignant cells and five-year survival. Cancer 31: 226-236, 1973.
7. Isenberg J, Stoffel B, Wolters U et al: Immunostimulation by Propionibacteria-effects on immune status and antineoplastic treatment. Anticancer Res 15: 2363-2368, 1995.
8. Ashwell G, Morell AG: The role of surface carbohydrates in the hepatic recognition and transport of circulating glycoproteins. Adv Enzymol 47: 99-128, 1974.
9. Uhlenbruck G: The Thomsen-Friedenreich receptor: an old history with hew mystery. Immunol Commun 10: 251-264, 1981.
10. Beuth J, Ko HL, Otte K, et al: Inhibition of liver metastasis in mice by blocking hepatocyte lectins with arabinogalactan infusions and D-galactose. J Cancer Res Clin Oncol 113: 51-55, 1987.
11. Beuth J, Ko HL, Schirrmacher V, et al: Inhibition of liver tumor cell colonization in two animal models by lectin blocking with D-galactose and arabinogalactan. Clin Exp Metastasis 6: 115-120, 1988.
12. Joshi SS, Sharp JG, Brunson KW: Differential growth characteristics of metastatic variant RAW 117 murine lymphosarcoma cells. Oncology 44: 180-185, 1987.
13. BMDP statistical software. Inc Los Angeles, CA 1990.
14. Dixon WJ, Brown MB, Engelman L: BMDP statistical software manual. Vol. 1, 2. University of California press, Berkeley 1990.
15. Beuth J, Ko HL, Otte K, et al: Inhibition of liver metastasis in mice by blocking hepatocyte lectins with arabinogalactan infusions and D-galactose. J Cancer Res Clin Oncol 113: 51-55, 1987.
16. Dennis JW, and Laferte S: Tumor cell surface carbohydrate and metastatic phenotype. Cancer Metastasis Rev 5: 185-204, 1987.
17. Fidler IJ, and Kripke ML: Metastasis results from pre-existing variant cells within a malignant tumor. Science 197: 883-895, 1987.
18. Beuth J, and Pulverer G: Lectin blocking: New strategies for the prevention and therapy of tumor metastasis and infectious diseases. G. Fischer Vlg., Stuttgart-Jena-New York, 1994.