Cardiopulmonary control in sleeping Sprague-Dawley rats treated with hydralazine

Journal of Applied Physiology

Volumn 83, Issue 6, 1997, Pages 1954-1961

  Carley, David W ^a,b   Trbovic, Sinisa M ^a   Bozanich, Alex ^a   Radulovacki, Miodrag ^a  

^a UNIVERSITY OF ILLINOIS   (United States)

^b UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

Apnea; Baroreflex; Hypotension; Respiration; Sleep; Telemetry

Indexed keywords

HYDRALAZINE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BLOOD PRESSURE; BREATHING PATTERN; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; HYPOTENSION; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; NONHUMAN; POLYSOMNOGRAPHY; PRIORITY JOURNAL; RAT; REM SLEEP; SLEEP APNEA SYNDROME;

EID: 0031454159     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/jappl.1997.83.6.1954     Document Type: Article

References (30)

1. Anonymous. Physician's Desk Reference (51 ed.) Montvale, NJ: Medical Economics, 1997.
2. Benington, J., S. Kodali, and C. Heller. Scoring transitions to REM sleep in rats based on the EEG phenomena of pre-REM sleep: an improved analysis of sleep structure. Sleep 17: 28-36, 1994.
3. Carley, D. W., S. Trbovic, and M. Radulovacki. Hydralazine reduces elevated sleep apnea index in spontaneously hypertensive (SHR) rats to equivalence with normotensive Wistar-Kyoto rats. Sleep 19: 363-366, 1996.
4. Carley, D. W., S. Trbovic, and M. Radulovacki. Sleep apnea in normal and REM sleep-deprived normotensive Wistar-Kyoto and spontaneously hypertensive (SHR) rats. Physiol. Behav. 59: 827-831, 1996.
5. Christon, J., D. W. Carley, D. Monti, and M. Radulovacki. Effects of inspired gas on sleep-related apnea in the rat. J. Appl. Physiol. 80: 2102-2107, 1996.
6. Epstein, R., M. Epstein, G. Haddad, and R. Mellins. Practical implementation of the barometric method for measurement of tidal volume. J. Appl. Physiol. 49: 1107-1115, 1980.
7. Fletcher, E., R. DeBehnke, M. Lovoi, and A. Gorin. Undiagnosed sleep apnea in patients with essential hypertension. Ann. Intern. Med. 103: 190-195, 1985.
8. Heistad, D., F. Abboud, and A. Mark. Effect of baroreceptor activity on ventilatory response to chemoreceptor stimulation. J. Appl. Physiol. 39: 411-416, 1975.
9. Levinson, P. D., and R. P. Millman. Causes and consequences of blood pressure alterations in obstructive sleep apnea. Arch. Intern. Med. 151: 455-462, 1991.
10. Loewy, A., and K. Spyer. Central Regulation of Autonomic Functions. New York: Oxford Univ. Press, 1990.
11. Mayer, J., H. Becker, U. Brandenburg, T. Penzel, J. H. Peter, and W. P. von Wichert. Blood pressure and sleep apnea: results of long-term nasal continuous positive airway pressure therapy. Cardiology 79: 84-92, 1991.
12. Mayer, J., and J. H. Peter. First experience with cilazapril in the treatment of sleep apnoea-related hypertension. Drugs 1: 37-47, 1991.
13. McNicholas, W., R. Rutherford, and R. Grossman. Abnormal respiratory pattern generation during sleep in patients with autonomic dysfunction. Am. Rev. Respir. Dis. 128: 429-433, 1983.
14. Mendelson, W., J. Martin, M. Perils, H. Giesen, R. Wagner, and S. Rapoport. Periodic cessation of respiratory effort during sleep in adult rats. Physiol. Behav. 43: 229-234, 1988.
15. Millman, R. P., S. Redline, C. C. Carlisle, A. R. Assaf, and P. D. Levinson. Daytime hypertension in obstructive sleep apnea. Prevalence and contributing risk factors. Chest 99: 861-866, 1991.
16. 1 analog reduces sleep apneas in rats. Pharmacol. Biochem. Behav. 53: 341-345, 1996.
17. Ohtake, P., and D. Jennings. Ventilation is stimulated by small reductions in arterial pressure in the awake dog. J. Appl. Physiol. 73: 1549-1557, 1992.
18. Persson, P. Modulation of cardiovascular control mechanisms and their interaction. Physiol. Rev. 76: 193-244, 1996.
19. Phillipson, E. Control of breathing during sleep. Am. Rev. Respir. Dis. 118: 909-939, 1978.
20. Robbe, H., L. Mulder, H. Rüddel, W. Langewitz, J. Veldman, and G. Mulder. Assessment of baroreceptor reflex sensitivity by means of spectral analysis. Hypertension 10: 538-543, 1987.
21. Sato, T., K. Saito, K. Seto, and H. Takatsuji. Sleep apneas and cardiac arrhythmias in freely moving rats. Am. J. Physiol. 259 (Regulatory Integrative Comp. Physiol. 28): R282-R287, 1990.
22. Schlenker, W. H., R. Means, and J. A. Burback. Naloxone stimulates oxygen consumption but not ventilation in hypothyroid hamsters. Physiol. Behav. 56: 635-638, 1994.
23. Smythe, H., P. Sleight, and G. Pickering. Reflex regulation of arterial pressure during sleep in man. Circ. Res. 24: 109-121, 1969.
24. Somers, V., and F. Abboud. Chemoreflex-responses, interactions and implications for sleep apnea. Sleep 16: S30-S34, 1993.
25. Somers, V., A. Mark, and F. Abboud. Sympathetic activation by hypoxia and hypercapnia-implications for sleep apnea. Clin. Exp. Hypertens. 1: 413-422, 1988.
26. Somers, V., A. Mark, and F. Abboud. Interaction of baroreceptor and chemoreceptor control of sympathetic nerve activity in normal humans. J. Clin. Invest. 87: 1953-1957, 1991.
27. Somers, V., A. Mark, D. Zavala, and F. Abboud. Contrasting effects of hypoxia and hypercapnia on ventilation and sympathetic activity in humans. J. Appl. Physiol. 67: 2101-2106, 1989.
28. Thomas, A., W. Austin, L. Friedman, and K. P. Strohl. A model of ventilatory instability induced in the unrestrained rat. J. Appl. Physiol. 73: 1530-1536, 1992.
29. Trbovic, S. M., M. Radulovacki, and D. W. Carley. Protoveratrines A and B increase sleep apnea index in Sprague-Dawley rats. J. Appl. Physiol. In press.
30. Walker, J. K., and D. B. Jennings. Ventilatory effects of angiotensin and vasopressin in conscious rats. Can. J. Physiol. Pharmacol. 74: 1258-1264, 1996.