Preventive effect of isoflurane on destruction of cytochrome P450 during reductive dehalogenation of carbon tetrachloride in guinea-pig liver microsomes

Drug Metabolism and Drug Interactions

Volumn 14, Issue 2, 1997, Pages 99-107

  Fujii, Kohyu ^a  

^a HIROSHIMA UNIV SCHOOL OF MEDICINE   (Japan)

Author keywords

Anaerobic; Carbon tetrachloride; Dechlorination; Destruction; Isoflurane

Indexed keywords

CARBON TETRACHLORIDE; CYTOCHROME P450; ISOFLURANE;

ANIMAL TISSUE; CONTROLLED STUDY; DEHALOGENATION; DESTRUCTION; DRUG EFFECT; DRUG METABOLISM; ENZYME DEGRADATION; GUINEA PIG; LIPID PEROXIDATION; LIVER MICROSOME; MALE; NONHUMAN; SHORT SURVEY;

EID: 0031453269     PISSN: 07925077     EISSN: None     Source Type: Journal    
DOI: 10.1515/DMDI.1997.14.2.99     Document Type: Short Survey

References (7)

1. Recknagel RO, Glende EA Jr, Hruszkewycz AM. Chemical mechanisms in carbon tetrachloride toxicity. In: Pryor WA, ed, Free Radicals in Biology, Vol. 3. New York: Academic Press, 1980; 97-132.
2. Toranzo EGD, Gomez MID, Castro JA. Mechanism of in vivo carbon tetrachloride-induced liver microsomal cytochrome P-450 destruction. Biochem Biophys Res Comm 1975; 64: 823-828.
3. Holaday DA, Fiserova-Bergerova V, Latto PI, Zumbiel MA. Resistance of isoflurane to biotransformation in man. Anesthesiology 1975; 43: 325-332.
4. Fujii K. Isoflurane enhances dechlorination of carbon tetrachloride in guinea pig liver microsomes. J Appl Toxicol 1996; 16: 249-253.
5. Fujii K. Stimulatory effect of anesthetics on dehalogenation of carbon tetrachloride in guinea pig liver microsomes. Toxicology 1996; 114: 147-153.
6. Omura T, Sato R. The carbon monoxide binding pigment of liver microsomes. J Biol Chem 1964; 239: 2370-2378.
7. Lowry OH, Rosebourg NJ, Farr AL, Randall RJ. Protein measurement with the Folin phenol reagent. J Biol Chem 1951; 193: 265-275.