Triazine herbicide exposure and breast cancer incidence: An ecologic study of Kentucky counties

Environmental Health Perspectives

Volumn 105, Issue 11, 1997, Pages 1222-1227

  Kettles, Michele A ^a   Browning, Steven R ^a   Prince, Timothy Scott ^a   Horstman, Sanford W ^a  

^a UNIVERSITY OF KENTUCKY   (United States)

Author keywords

Breast cancer; Ecologic study; Organochlorines; Pesticides; Triazine herbicides; Xenoestrogens

Indexed keywords

ESTROGEN; HERBICIDE; ORGANOCHLORINE PESTICIDE; TRIAZINE;

ARTICLE; BREAST CANCER; CANCER RISK; CORN; CROP; FEMALE; HUMAN; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; REGRESSION ANALYSIS; RISK FACTOR; UNITED STATES; WATER CONTAMINATION;

ZEA MAYS;

EID: 0031453016     PISSN: 00916765     EISSN: None     Source Type: Journal    
DOI: 10.1289/ehp.971051222     Document Type: Article

References (45)

1. U.S. EPA. The Triazine Herbicides, Atrazine, Simazine, Cyanazine: Position Document 1, Initiation of Special Review. EPA OPP-30000-60. Washington, DC:U.S. Environmental Protection Agency, 1994.
2. Department of Entomology, Cooperative Extension Service, College of Agriculture, University of Kentucky. Kentucky Pesticide User Practices and Alternatives, 1992. Lexington, KY:University of Kentucky, 1993.
3. Department of Entomology, Cooperative Extension Service, College of Agriculture, University of Kentucky. Kentucky Pesticide User Practices and Alternatives, 1990. Lexington, KY:University of Kentucky, 1991.
4. Pinter A, Torok G, Borzsonyi A, Surjan A, Csik M, Kelecsenyi Z, Kocsis J. Long-term carcinogenicity bioassay of the herbicide atrazine in F344 rats. Neoplasma 37:533-544 (1990).
5. Stevens JT, Breckenridge CB, Wetzel LT, Gillis JH, Leumpert LG, Eldridge JC. Hypothesis for mammary tumorigenesis in Sprague-Dawley rats exposed to certain triazine herbicides. J Toxicol Environ Health 43:139-153 (1994).
6. Ma L, Selim HM. Atrazine retention and transport in soils. Rev Environ Contam Toxicol 145:129-173 (1996).
7. Davis DL, Bradlow HL, Wolff M, Woodruff T, Hoel DG, Anton-Culver H. Medical hypothesis: xenoestrogens as preventable causes of breast cancer. Environ Health Perspect 101:372-377 (1993).
8. Telang NT, Suto A, Wong GY, Osborne MP, Bradlow HL. Induction by estrogen metabolite 16α-hydroxyestrone of genotoxic damage and aberrant proliferation in mouse mammary epithelial cells. J Natl Cancer Inst 84:634-638 (1992).
9. Bradlow HL, Michnovicz JJ, Telang NT, Osborne MP, Goldin BR. Diet, oncogenes and tumor viruses as modulators of estrogen metabolism in vivo and in vitro. Cancer Prev Detect S16:35-42 (1991).
10. Bradlow HL, Michnovicz JJ, Telang NT, Osborne MP. Effect of dietary indole-3-carbinol on estradiol metabolism and spontaneous mammary tumors in mice. Carcinogenesis 12:1571-1574 (1991).
11. Welsch CW. Host factors affecting the growth of carcinogen-induced rat mammary carcinomas: a review and tribute to Charles Brenton Huggins. Cancer Res 45:3415-3443 (1985).
12. Welch RM, Levin W, Conney AH. Estrogenic action of DDT and its analogs. Toxicol Appl Pharmacol 14:358-367 (1969).
13. Korach KS, Sarver P, Chae K, McLachlan JA, McKinney JD. Estrogen receptor binding activity of polychlorinated hydroxybiphenyls: conformationally restricted structural probes. Mol Pharmacol 33:120-126 (1988).
14. Soto AM, Lin TM, Justicia H, Silvia RM, Sonnenschein C. An "in culture" bioassay to assess the estrogenicicy of xenobiotics (E-screen). In: Chemically-induced Alterations in Sexual and Functional Development: The Wildlife/Human Connection (Colborn T, Clement C, eds). Princeton, NJ: Princeton Scientific Publishing, 1992;295-309.
15. Wolff MS, Toniolo PG, Lee EW, Rivera M, Dubin N. Blood levels of organochlorine residues and risk of breast cancer. J Natl Cancer Inst 85:648-652 (1993).
16. Krieger N, Wolff MS, Hiatt RA, Rivera M, Vogelman J, Orentreich N. Breast cancer and serum organochlorines: a prospective study among white, black, and Asian women. J Natl Cancer Inst 86:589-599 (1994).
17. Manz A, Berger J, Dwyer JH, Flesch-Janys D, Nagel S, Waltsgott H. Cancer mortality among workers in a chemical plant contaminated with dioxin. Lancet 338:959-964 (1991).
18. Dusich K, Sigurson E, Hall WN, Dean AG. Cancer rates in a community exposed to low levels of creosote components in municipal water. Minn Med 63:803-806 (1980).
19. Hall NE, Rosenman KD. Cancer by industry: analysis of a population based cancer registry with an emphasis on blue collar workers. Am J Ind Med 19:145-159 (1991).
20. Griffith J, Duncan R, Riggan WB, Pellom AC. Cancer mortality in U.S. counties with hazardous waste sites and groundwater pollution. Arch Environ Health 44:69-74 (1989).
21. Westin JB, Richter E. The Israeli breast cancer anomaly. Ann NY Acad Sci 609:269-279 (1990).
22. Centers for Disease Control and Prevention. Breast cancer incidence and mortality - United States, 1992. MMWR 45(39):834-837 (1996).
23. Feuer EJ, Wun L-M. How much of the recent rise in breast cancer incidence can be explained by increases in mammography utilization? A dynamic population model approach. Am J Epidemiol 136:1423-1436 (1992).
24. Kelsey JL. Breast cancer epidemiology: summary and future directions. Epidemiol Rev 15:256-263 (1993).
25. Arnold SF, Klotz DM, Collins BM, Vonier PM, Guillette LJ, McLachlan JA. Synergistic activation of estrogen receptor with combinations of environmental chemicals. Science 272:1489-1492 (1996).
26. Fagliano J, Berry M, Bove F, Burke T. Drinking water contamination and the incidence of leukemia; an ecologic study. Am J Public Health 80:1209-1212 (1990).
27. Carpenter LM, Beresford SA. Cancer mortality and type of water source: findings from a study in the UK. Int J Epidemiol 15:312-320 (1986).
28. Cech I, Holguin AH, Littell AS, Hentry JP, O'Connell J. Health significance of chlorination byproducts in drinking water: the Houston experience. Inc J Epidemiol 16:198-207 (1987).
29. Aschengrau A, Ozonoff D, Paulu C, Coogan P, Vezina R, Heeren T, Zhang Y. Cancer risk and tetrachloroethylene-contaminated drinking water in Massachusetts. Arch Environ Health 49:284-292 (1993).
30. Millikan R, DeVoto E, Neuman B, Savitz D. Studying environmental influences and breast cancer risk: suggestions for an integrated population based approach. Breast Cancer Res Treat 35:79-89 (1995).
31. U.S. Census Bureau - 1990 Census Lookup [On-line]. 1990 Census Summary Tape File 3 (STF3) - All Socioeconomic and Demographic Variables. Washington, DC:U.S. Department of Commerce. Available: http://venus.census.gov/cdrom/lookup
32. Carey DI, Dinger JS, Davidson OB, Sergeant RE, Taraba JL, Elvento TW, Coleman S, Boone R, Knoth LM. Quality of Private Ground-water Supplies in Kentucky. Lexington, KY:University of Kentucky, Kentucky Geological Survey, 1993.
33. Kentucky Department of Agriculture, Kentucky Agricultural Statistics Service. Kentucky Agricultural Statistics, 1970. Louisville, KY:Kentucky Department of Agriculture, 1971.
34. Department of Entomology, Cooperative Extension Service, College of Agriculture, University of Kentucky. Pesticide Use by Kentucky Certified Applicators, 1979. Lexington, KY:University of Kentucky, 1981.
35. Kentucky Cancer Registry. 1994 Cancer Incidence Report. Lexington, KY:University of Kentucky, 1995.
36. Kentucky Cancer Registry, 1992 Cancer Incidence Report. Lexington, KY:University of Kentucky, 1993.
37. Kelsey JL, Gammon MD, Epidemiology of breast cancer. Epidemiol Rev 12:228-240 (1990).
38. van Loon AJ, Brug J, Goldbohm RA, van den Brandt PA, Brug J. Differences in cancer incidence and mortality among socioeconomic groups. Scand J Soc Med 23:110-120 (1995).
39. Breslow NE, Day NE. Statistical Methods in Cancer Research, Vol II. Lyon:International Agency for Research on Cancer, 1987.
40. SAS Institute, Inc. SAS/Stat User's Guide. 6th ed. Cary, NC:SAS Institute, Inc., 1990.
41. Morgenstern H. Uses of ecologic analysis in epidemiologic research. Am J Public Health 72:1336-1344(1982).
42. Morgenstern H. Ecologic studies in epidemiology: concepts, principles, and methods. Annu Rev Public Health 16:61-81 (1995).
43. Rothman KJ. Modern Epidemiology. Boston, MA:Little, Brown and Company, 1986.
44. Dunnick JK, Melnick RL. Assessment of the carcinogenic potential of chlorinated water: experimental studies of chlorine, chloramine, and trihalomethanes, J Natl Cancer Inst 85:817-822 (1993).
45. McGeehin MA, Reif JS, Becher JC, Mangione EJ. Case - control study of bladder cancer and water disinfection methods in Colorado. Am J Epidemiol 138:492-501 (1993).