Delivery of non-toxic fragments of Clostridium difficile toxin a to the mucosal immune system

Reviews and Research in Medical Microbiology

Volumn 8, Issue SUPPL. 1, 1997, Pages

  Ward, Stephen J ^a,b   Douce, Gill ^a,b   Dougan, Gordon ^a,c   Wren, Brendan W ^a,d  

^a Department of Microbiology   (United Kingdom)

^b QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^c IMPERIAL COLLEGE LONDON   (United Kingdom)

^d Department of Microbiology

Author keywords

Clostridhim difficile; Mucosal immunity; Toxin A; Vaccine

Indexed keywords

ANTIGEN; CLOSTRIDIUM DIFFICILE TOXIN A; HYBRID PROTEIN; TETANUS TOXIN; VACCINE;

CARBOXY TERMINAL SEQUENCE; CONFERENCE PAPER; EXPRESSION VECTOR; GASTROINTESTINAL MUCOSA; IMMUNE SYSTEM; MUCOSA; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RECEPTOR BINDING; SALMONELLA TYPHIMURIUM;

EID: 0031452893     PISSN: 0954139X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00013542-199712001-00016     Document Type: Article

References (4)

1. Lyerly DM, Johnson JL, Frey SM, Wilkins TD. Vaccination against lethal Clostridium difficile enterocolitis with a nontoxic recombinant peptide of toxin A. Curr Microbiol 1990; 21:2933.
2. Wren BW, Russell RR, Tabaqchali S. Antigenic cross-reactivity and functional inhibition by antibodies to Clostridium difficile toxin A, Streptococcus mutons glucan-binding protein, and a synthetic peptide. Infect Immun 1991; 59:3151-3155.
3. Anjam Khan CM, Villarreal-Ramos B, Pierce RJ, et al. Construction, expression and immunogenicity of the Schistosoma mansoni P28 glutathione S-transferase as a genetic fusion to tetanus toxin fragment C in a live Arc. attenuated vaccine strain of Salmonella. Proc Natl Acad Sei USA 1994; 91:1126111265.
4. Tacket CO, Sztein MB, Losonsky GA, et al. Safety of live oral Salmonella typhi vaccine strains with deletions in htrA and aroC aroD and immune responses in humans. Infect Immun 1997; 65: 452-456.