메뉴 건너뛰기




Volumn 36, Issue 3, 1997, Pages 179-189

HIV-1 acquires resistance to two classes of antiviral drugs through homologous recombination

Author keywords

Antiviral drugs; HIV 1; Homologous recombination; Resistance

Indexed keywords

ANTIVIRUS AGENT; DIDANOSINE; KYNOSTATIN 272; PROTEINASE; PROTEINASE INHIBITOR; RNA DIRECTED DNA POLYMERASE; VIRUS ENZYME; ZALCITABINE; ZIDOVUDINE;

EID: 0031452514     PISSN: 01663542     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0166-3542(97)00053-3     Document Type: Article
Times cited : (34)

References (38)
  • 1
    • 0344913977 scopus 로고
    • In vitro induction of HIV-1 with reduced sensitivity to HIV protease inhibitors, KNI-227 and KNI-272
    • August 7-12, Yokohama, Japan
    • Anderson, B.D., Kageyama, S., Ueno, T., Mitsuya, H., 1994. In vitro induction of HIV-1 with reduced sensitivity to HIV protease inhibitors, KNI-227 and KNI-272, pp. 60. Tenth International Conference on AIDS, August 7-12, Yokohama, Japan.
    • (1994) Tenth International Conference on AIDS , pp. 60
    • Anderson, B.D.1    Kageyama, S.2    Ueno, T.3    Mitsuya, H.4
  • 2
    • 0024438889 scopus 로고
    • Specificity and mechanisms of error-prone replication by human immunodeficiency virus-1 reverse transcriptase
    • Bebenek K., Abbotts J., Roberts J.D., Wilson S.H., Kunkel T.A. Specificity and mechanisms of error-prone replication by human immunodeficiency virus-1 reverse transcriptase. J. Biol. Chem. 262:1989;16948-16956.
    • (1989) J. Biol. Chem. , vol.262 , pp. 16948-16956
    • Bebenek, K.1    Abbotts, J.2    Roberts, J.D.3    Wilson, S.H.4    Kunkel, T.A.5
  • 3
    • 1842456277 scopus 로고
    • Sequence analysis of virus variability based on the polymerase chain reaction PCR
    • In: J. Karn (Ed.), Oxford University Press, IRL Press, Oxford
    • Brown, A.J.L., Simmonds, P., 1995. Sequence analysis of virus variability based on the polymerase chain reaction PCR. In: J. Karn (Ed.), HIV Virology and Immunology Vol. 1, Oxford University Press, IRL Press, Oxford, pp. 161-188.
    • (1995) HIV Virology and Immunology , vol.1 , pp. 161-188
    • Brown, A.J.L.1    Simmonds, P.2
  • 4
    • 0003358914 scopus 로고    scopus 로고
    • Retroviridae: The viruses and their replication
    • In: B.N. Fields, D.M. Knipe, P.M. Howley (Eds.), Lipponcott-Raven Publishers, Philadelphia 2
    • Coffin, J.M., 1996. Retroviridae: The viruses and their replication. In: B.N. Fields, D.M. Knipe, P.M. Howley (Eds.), Fields Virology. 3rd ed. Lipponcott-Raven Publishers, Philadelphia 2, pp. 1767-1847.
    • (1996) Fields Virology. 3rd Ed. , pp. 1767-1847
    • Coffin, J.M.1
  • 6
    • 0028120730 scopus 로고
    • HIV resistance to reverse transcriptase inhibitors
    • De Clercq E. HIV resistance to reverse transcriptase inhibitors. Biochem. Pharmacol. 47:1994;155-169.
    • (1994) Biochem. Pharmacol. , vol.47 , pp. 155-169
    • De Clercq, E.1
  • 7
    • 0006956461 scopus 로고
    • Detection of homologous recombinants
    • In: A.A. Innis, D.H. Gelfand, J.J. Sninsky, T.J. White, T.J., (Eds.), Academic Press Limited, London
    • Frohman, M.A., Martin, G.R., 1990. Detection of homologous recombinants. In: A.A. Innis, D.H. Gelfand, J.J. Sninsky, T.J. White, T.J., (Eds.), PCR Protocols. Academic Press Limited, London.
    • (1990) PCR Protocols
    • Frohman, M.A.1    Martin, G.R.2
  • 8
    • 0028034266 scopus 로고
    • The K65R mutant reverse transcriptase of HIV-1 cross-resistant to 2′,3′-dideoxycytidine, 2′,3′-dideoxy-3′-thiacytidine, and 2′,3′-dideoxyinosine shows reduced sensitivity to specific dideoxynucleoside triphosphate inhibitors in vitro
    • Gu Z., Fletcher R.S., Arts E.J., Wainberg M.A., Parniak M.A. The K65R mutant reverse transcriptase of HIV-1 cross-resistant to 2′,3′-dideoxycytidine, 2′,3′-dideoxy-3′-thiacytidine, and 2′,3′-dideoxyinosine shows reduced sensitivity to specific dideoxynucleoside triphosphate inhibitors in vitro. J. Biol. Chem. 269:1994;28118-28122.
    • (1994) J. Biol. Chem. , vol.269 , pp. 28118-28122
    • Gu, Z.1    Fletcher, R.S.2    Arts, E.J.3    Wainberg, M.A.4    Parniak, M.A.5
  • 9
    • 0028884070 scopus 로고
    • Possible involvement of cell fusion and viral recombination in generation of human immunodeficiency virus variants that display dual resistance to AZT and 3TC
    • Gu Z., Gao Q., Faust E.A., Wainberg M.A. Possible involvement of cell fusion and viral recombination in generation of human immunodeficiency virus variants that display dual resistance to AZT and 3TC. J. Gen. Virol. 76:1995;2601-2605.
    • (1995) J. Gen. Virol. , vol.76 , pp. 2601-2605
    • Gu, Z.1    Gao, Q.2    Faust, E.A.3    Wainberg, M.A.4
  • 11
    • 0025095253 scopus 로고
    • Genetic sequence of packaging two RNA genomes in one retroviral particle; Pseudodiploidy and high rate of genetic recombination
    • Hu W.S., Temin H.M. Genetic sequence of packaging two RNA genomes in one retroviral particle; pseudodiploidy and high rate of genetic recombination. Proc. Natl. Acad. Sci. U.S.A. 87:1990;1556-1560.
    • (1990) Proc. Natl. Acad. Sci. U.S.A. , vol.87 , pp. 1556-1560
    • Hu, W.S.1    Temin, H.M.2
  • 13
    • 0005150171 scopus 로고    scopus 로고
    • The relation of virologic and immunologic markers to clinical outcomes after nucleoside therapy in HIV-infected adults with 200-500 CD4 cells per cubic millimeter. AIDS Clinical Trials Group Study 175 Virology Study Team
    • Katzenstein D.A., Hammer S.M., Hughes M.D., Gundacker H., Jackson J.B., Fiscus S., Rasheed S., Elbeik T., Reichman R., Japour A., Merigan T.C., Hirsch M.S. The relation of virologic and immunologic markers to clinical outcomes after nucleoside therapy in HIV-infected adults with 200-500 CD4 cells per cubic millimeter. AIDS Clinical Trials Group Study 175 Virology Study Team. N. Engl. J. Med. 335:1996;1091-1098.
    • (1996) N. Engl. J. Med. , vol.335 , pp. 1091-1098
    • Katzenstein, D.A.1    Hammer, S.M.2    Hughes, M.D.3    Gundacker, H.4    Jackson, J.B.5    Fiscus, S.6    Rasheed, S.7    Elbeik, T.8    Reichman, R.9    Japour, A.10    Merigan, T.C.11    Hirsch, M.S.12
  • 14
    • 0028874043 scopus 로고
    • Retroviral recombination can lead to linkage of reverse transcriptase mutations that confer increased zidovudine resistance
    • Kellam P., Larder B.A. Retroviral recombination can lead to linkage of reverse transcriptase mutations that confer increased zidovudine resistance. J. Virol. 69:1995;669-674.
    • (1995) J. Virol. , vol.69 , pp. 669-674
    • Kellam, P.1    Larder, B.A.2
  • 15
    • 0028909530 scopus 로고
    • Human immunodeficiency virus type 1 (HIV-1) viremia changes and development of drug-related mutations in patients with symptomatic HIV-1 infection receiving alternating or simultaneous zidovudine and didanosine therapy
    • Kojima E., Shirasaka T., Anderson B.D., Chokekijchai S., Steinberg S.M., Broder S., Yarchoan R., Mitsuya H. Human immunodeficiency virus type 1 (HIV-1) viremia changes and development of drug-related mutations in patients with symptomatic HIV-1 infection receiving alternating or simultaneous zidovudine and didanosine therapy. J. Infect. Dis. 171:1995;1152-1158.
    • (1995) J. Infect. Dis. , vol.171 , pp. 1152-1158
    • Kojima, E.1    Shirasaka, T.2    Anderson, B.D.3    Chokekijchai, S.4    Steinberg, S.M.5    Broder, S.6    Yarchoan, R.7    Mitsuya, H.8
  • 16
    • 0027463697 scopus 로고
    • A mutation in human immunodeficiency virus reverse transcriptase and decline in CD4 lymphocyte numbers in long-term zidovudine recipients
    • Kozal M.J., Shafer R.W., Winters M.A., Katzenstein D.A., Merigan T.C. A mutation in human immunodeficiency virus reverse transcriptase and decline in CD4 lymphocyte numbers in long-term zidovudine recipients. J. Infect. Dis. 167:1993;526-532.
    • (1993) J. Infect. Dis. , vol.167 , pp. 526-532
    • Kozal, M.J.1    Shafer, R.W.2    Winters, M.A.3    Katzenstein, D.A.4    Merigan, T.C.5
  • 17
    • 0024310253 scopus 로고
    • Multiple mutations in HIV-1 reverse transcriptase confer high-level resistance to zidovudine (AZT)
    • Larder B.A., Kemp S.D. Multiple mutations in HIV-1 reverse transcriptase confer high-level resistance to zidovudine (AZT). Science. 246:1989;1155-1158.
    • (1989) Science , vol.246 , pp. 1155-1158
    • Larder, B.A.1    Kemp, S.D.2
  • 18
    • 0027486945 scopus 로고
    • Convergent combination therapy can select viable multidrug-resistant HIV-1 in vitro
    • Larder B.A., Kellam P., Kemp S.D. Convergent combination therapy can select viable multidrug-resistant HIV-1 in vitro. Nature. 365:1993;451-453.
    • (1993) Nature , vol.365 , pp. 451-453
    • Larder, B.A.1    Kellam, P.2    Kemp, S.D.3
  • 19
    • 0344482714 scopus 로고    scopus 로고
    • Emergence of multi-dideoxynucleoside-resistant HIV-1 in patients receiving long-term combination therapy with dideoxynucleosides
    • July 3-6, Whistler, Canada
    • Maeda, Y., Mitsuya H., 1996. Emergence of multi-dideoxynucleoside-resistant HIV-1 in patients receiving long-term combination therapy with dideoxynucleosides. Fifth International Workshop, July 3-6, Whistler, Canada, pp. 40.
    • (1996) Fifth International Workshop , pp. 40
    • Maeda, Y.1    Mitsuya, H.2
  • 20
    • 0029075130 scopus 로고
    • Lower in vivo mutation rate of human immunodeficiency virus type 1 than that predicted from the fidelity of purified reverse transcriptase
    • Mansky L.M., Temin H.M. Lower in vivo mutation rate of human immunodeficiency virus type 1 than that predicted from the fidelity of purified reverse transcriptase. J. Virol. 69:1995;5087-5094.
    • (1995) J. Virol. , vol.69 , pp. 5087-5094
    • Mansky, L.M.1    Temin, H.M.2
  • 22
    • 0026793703 scopus 로고
    • Kynostatin (KNI)-227 and -272, highly potent anti-HIV agents: Conformationally constrained tripeptide inhibitors of HIV protease containing allophenyl-norstatine
    • Mimoto T., Imai J., Kisanuki S., Enomoto H., Hattori N., Akaji K., Kiso Y. Kynostatin (KNI)-227 and -272, highly potent anti-HIV agents: conformationally constrained tripeptide inhibitors of HIV protease containing allophenyl-norstatine. Chem. Pharm. Bull. 40:1992;2251-2253.
    • (1992) Chem. Pharm. Bull. , vol.40 , pp. 2251-2253
    • Mimoto, T.1    Imai, J.2    Kisanuki, S.3    Enomoto, H.4    Hattori, N.5    Akaji, K.6    Kiso, Y.7
  • 23
    • 0027516771 scopus 로고
    • Clinical correlates of in vitro HIV-1 resistance to zidovudine. Results of the multicentre Canadian AZT trial
    • Montaner J.S.G., Singer J., Schechter M.T., Raboud J.M., Wainberg M.A. Clinical correlates of in vitro HIV-1 resistance to zidovudine. Results of the multicentre Canadian AZT trial. AIDS. 7:1993;189-196.
    • (1993) AIDS , vol.7 , pp. 189-196
    • Montaner, J.S.G.1    Singer, J.2    Schechter, M.T.3    Raboud, J.M.4    Wainberg, M.A.5
  • 24
    • 0029973141 scopus 로고    scopus 로고
    • Recombination leads to the rapid emergence of HIV-1 dually resistant mutations umder selective drug pressure
    • Moutouh L., Corbeil J., Richman D.D. Recombination leads to the rapid emergence of HIV-1 dually resistant mutations umder selective drug pressure. Proc. Natl. Acad. Sci. U.S.A. 93:1996;6106-6111.
    • (1996) Proc. Natl. Acad. Sci. U.S.A. , vol.93 , pp. 6106-6111
    • Moutouh, L.1    Corbeil, J.2    Richman, D.D.3
  • 25
    • 0024267430 scopus 로고
    • Fidelity of HIV-1 reverse transcriptase
    • Preston B.D., Poiesz B.J., Loeb L.A. Fidelity of HIV-1 reverse transcriptase. Science. 242:1988;1168-1171.
    • (1988) Science , vol.242 , pp. 1168-1171
    • Preston, B.D.1    Poiesz, B.J.2    Loeb, L.A.3
  • 27
    • 0026318387 scopus 로고
    • Human immunodeficiency virus type 1 mutants resistant to non-nucleoside inhibitors of reverse transcriptase arise in tissue culture
    • Richman D.D., Shih C.K., Lowry I., Rose J., Prodanovich P., Goff S., Griffin J. Human immunodeficiency virus type 1 mutants resistant to non-nucleoside inhibitors of reverse transcriptase arise in tissue culture. Proc. Natl. Acad. Sci. U.S.A. 88:1991;11241-11243.
    • (1991) Proc. Natl. Acad. Sci. U.S.A. , vol.88 , pp. 11241-11243
    • Richman, D.D.1    Shih, C.K.2    Lowry, I.3    Rose, J.4    Prodanovich, P.5    Goff, S.6    Griffin, J.7
  • 28
    • 0011129306 scopus 로고
    • In: Coligan, J.E., Kruisbeek, A.M., Margulies, D.H., Shevach, E.M., Strober, W. (Eds.), Wiley Interscience, Baltimore, MD.
    • Richman, D.D., Johnson, D.L., Mayor, T., Shirasaka, T., O'Brien, M.C., Mitsuya, H., 1993b. Current Protocol in Immunology. In: Coligan, J.E., Kruisbeek, A.M., Margulies, D.H., Shevach, E.M., Strober, W. (Eds.), Wiley Interscience, Baltimore, MD. pp. 12.9.1-12.9.21.
    • (1993) Current Protocol in Immunology , pp. 1291-12921
    • Richman, D.D.1    Johnson, D.L.2    Mayor, T.3    Shirasaka, T.4    O'Brien, M.C.5    Mitsuya, H.6
  • 29
    • 0024273119 scopus 로고
    • The accuracy of reverse transcriptase from HIV-1
    • Roberts J.D., Bebenek K., Kunkel T.A. The accuracy of reverse transcriptase from HIV-1. Science. 242:1988;1171-1173.
    • (1988) Science , vol.242 , pp. 1171-1173
    • Roberts, J.D.1    Bebenek, K.2    Kunkel, T.A.3
  • 31
    • 0027398296 scopus 로고
    • Changes in drug sensitivity of human immunodeficiency virus type 1 during therapy with azidothymidine, dideoxycytidine, and dideoxyinosine: An in vitro comparative study
    • Shirasaka T., Yarchoan R., O'Brien M.C., Husson R.N., Anderson B.D., Kojima E., Shimada T., Broder S., Mitsuya H. Changes in drug sensitivity of human immunodeficiency virus type 1 during therapy with azidothymidine, dideoxycytidine, and dideoxyinosine: an in vitro comparative study. Proc. Natl. Acad. Sci. U.S.A. 90:1993;562-566.
    • (1993) Proc. Natl. Acad. Sci. U.S.A. , vol.90 , pp. 562-566
    • Shirasaka, T.1    Yarchoan, R.2    O'Brien, M.C.3    Husson, R.N.4    Anderson, B.D.5    Kojima, E.6    Shimada, T.7    Broder, S.8    Mitsuya, H.9
  • 33
    • 0026608762 scopus 로고
    • Homologous recombination of copackaged retrovirus RNAs during reverse transcription
    • Stuhlmann H., Berg P. Homologous recombination of copackaged retrovirus RNAs during reverse transcription. J. Virol. 66:1992;1278-2388.
    • (1992) J. Virol. , vol.66 , pp. 1278-2388
    • Stuhlmann, H.1    Berg, P.2
  • 35
    • 0028784434 scopus 로고
    • Enzymatic characterization of human immunodeficiency virus type 1 reverse transcriptase resistant to multiple 2′,3′-dideoxynucleoside 5′-triphosphates
    • Ueno T., Shirasaka T., Mitsuya H. Enzymatic characterization of human immunodeficiency virus type 1 reverse transcriptase resistant to multiple 2′,3′-dideoxynucleoside 5′-triphosphates. J. Biol. Chem. 270:1995;23605-23611.
    • (1995) J. Biol. Chem. , vol.270 , pp. 23605-23611
    • Ueno, T.1    Shirasaka, T.2    Mitsuya, H.3
  • 36
    • 0025203707 scopus 로고
    • Strategies for the combination therapy of HIV infection
    • Yarchoan R., Mitsuya H., Broder S. Strategies for the combination therapy of HIV infection. J. AIDS. 3(suppl 2):1990;S99-S103.
    • (1990) J. AIDS , vol.3 , Issue.SUPPL. 2
    • Yarchoan, R.1    Mitsuya, H.2    Broder, S.3
  • 37
    • 0028010789 scopus 로고
    • A randomized pilot study of alternating and simultaneous regimens of zidovudine (AZT) and didanosine (ddI) in patients with symptomatic human immunodeficiency virus (HIV) infection
    • Yarchoan R., Lietzau J.A., Ngyen B.Y., Brawley O.W., Pluda J.M., Wyvill K.M., Steinberg S.M., Agbaria R., Mitsuya H., Broder S. A randomized pilot study of alternating and simultaneous regimens of zidovudine (AZT) and didanosine (ddI) in patients with symptomatic human immunodeficiency virus (HIV) infection. J. Infect. Dis. 169:1994;9-17.
    • (1994) J. Infect. Dis. , vol.169 , pp. 9-17
    • Yarchoan, R.1    Lietzau, J.A.2    Ngyen, B.Y.3    Brawley, O.W.4    Pluda, J.M.5    Wyvill, K.M.6    Steinberg, S.M.7    Agbaria, R.8    Mitsuya, H.9    Broder, S.10
  • 38
    • 0028031833 scopus 로고
    • Resistance to 2′,3′-dideoxycytidine conferred by a mutation in codon 65 of the human immunodeficiency virus type 1 reverse transcriptase
    • Zhang D., Caliendo A.M., Eron J.J., Devore K.M., Kaplan J.C., Hirsch M.S., D'Aquila R.T. Resistance to 2′,3′-dideoxycytidine conferred by a mutation in codon 65 of the human immunodeficiency virus type 1 reverse transcriptase. Antimicrob. Agents Chemother. 38:1994;282-287.
    • (1994) Antimicrob. Agents Chemother. , vol.38 , pp. 282-287
    • Zhang, D.1    Caliendo, A.M.2    Eron, J.J.3    Devore, K.M.4    Kaplan, J.C.5    Hirsch, M.S.6    D'Aquila, R.T.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.