A new rapidly disintegrating formulation of cisapride is bioequivalent to standard cisapride tablets in the elderly

Clinical Drug Investigation

Volumn 14, Issue 6, 1997, Pages 487-493

  Zhou, Honghui ^a   Herron, Jerry ^b   Liu, Yin ^a   Lee, Peter ^a   Pesco Koplowitz, Luana ^a  

^a JANSSEN RESEARCH AND DEVELOPMENT   (United States)

^b Research Solutions LLC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CISAPRIDE; QUICKSOLV; UNCLASSIFIED DRUG;

AGED; AREA UNDER THE CURVE; ARTICLE; BIOEQUIVALENCE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DIARRHEA; DRUG BLOOD LEVEL; DRUG FORMULATION; DRUG TOLERABILITY; DYSPEPSIA; FEMALE; GASTROINTESTINAL SYMPTOM; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; VOMITING;

EID: 0031452264     PISSN: 11732563     EISSN: None     Source Type: Journal    
DOI: 10.2165/00044011-199714060-00007     Document Type: Article

References (10)

1. Wiseman LR, Faulds D. Cisapride: an updated review of its pharmacology and therapeutic efficacy as a prokinetic agent in gastrointestinal motility disorders. Drugs 1994; 47: 161-52
2. Friedman LS, Castell DO. Esophageal diseases in the elderly. In: Castell DO, editor. The Esophagus, 2nd ed. New York: Little Brown & Company, 1995: 775-90
3. Bloem BR, Lagaay AM, van Beek W, et al. Prevalence of subjective dysphagia in community residents aged over 87. BMJ 1990; 300: 721-2
4. Kuhlemeier KV. Epidemiology and dysphagia. Dysphagia 1994; 9 (4): 209-17
5. Luther P, Baldus D, Beckham V, et al. Adherence to prescribed medications in elderly patients with congestive heart failure. Cardiovasc Rev Rep 1995; 16: 32-4;39-40
6. Woestenborghs R, Lorreyne W, Van Rompaey F, et al. Determination of cisapride in plasma and animal tissues by high performance liquid chromatography. J Chromatogr 1988; 424: 195-200
7. Shiina Y, Miwa T. Phase I study of cisapride. Single oral dosing study. Rinsho Yakuri 1985; 16: 489-502
8. Schuirmann D. A comparison of the two one-sided tests procedure and the power approach for assessing the equivalence of average bioavailability. J Pharmacokinet Biopharm 1987; 15: 657-80
9. Meuldermans W, Van Peer A, Hendrickx J, et al. Excretion and biotransformation of cisapride in dogs and humans after oral administration. Drug Metab Dispos 1988; 16: 403-9
10. Van Peer A, Verlinden M, Woestenborghs R, et al. Clinical pharmacokinetics of cisapride. In: Johnson AG, Lux G, editors. Progress in the treatment of gastrointestinal motility disorders: the role of cisapride. Amsterdam: Excerpta Medica, 1988: 23-9